dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0054145
Uniprot Accession Z4YJP0; Z4YJP0_MOUSE;
Genbank Protein ID NP_034560.2;
Genbank Nucleotide ID NM_010430.2;
Protein Name Hypermethylated in cancer 1 protein
Protein Synonyms/Alias
Gene Name Hic1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
140EDGPARQTDRGPGGRPhosphoSitePlus22135298
Sequence
(Fasta)
MITRMRHHPW LKSSSFEDRT FPSPPPNWRD ITYKYVLGST QHKTPRFMGL PGPISESPGG 60
HIWKRANLQD LLSSASASLL AQVCARGRSP AAHSPRVAAR WRHGRGSVCR FGPLQIRVCG 120
KRGGAETRPG RGEDGPARQT DRGPGGRRAA HCSHVPPWIR RQPGPGLPTC PPGECAGQTM 180
LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI IVVQNALFRA HKNVLAASSA YLKSLVVHDN 240
LLNLDHDMVS PAVFRLVLDF IYTGRLTDSV EAAAAAAVAP GAEPSLGAVL AAASYLQIPD 300
LVALCKKRLK RHGKYCHLRG GGSGGGGYAP YGRPGRGLRA ATPVIQACYS SPAGPPPPPA 360
AEPPSGPDAA VNTHCAELYA SGPGPAASLC APERRCSPLC GLDLSKKSPP GSSVPERPLS 420
ERELPPRPDS PPGAGPAVYK EPSLALPPLP PLPFQKLEEA VPTPDPFRGS GGSPGPEPPG 480
RPDGSSLLYR WMKHEPGLGS YGDELVRDRG SPGERLEERG GDPAASPGGP PLGLVPPPRY 540
PGSLDGPGTG ADGDDYKSSS EETGSSEDPS PPGGHLEGYP CPHLAYGEPE SFGDNLYVCI 600
PCGKGFPSSE QLNAHVEAHV EEEEALYGRA EAAEVAAGAA GLGPPFGGGG DKVTGAPGGL 660
GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC GKKFTQRGTM TRHMRSHLGL 720
KPFACDACGM RFTRQYRLTE HMRIHSGEKP YECQVCGGKF AQQRNLISHM KMHAVGGAAG 780
AAGALAGLGG LPGVPGPDGK GKLDFPEGVF AVARLTAEQL SLKQQDKAAA AELLAQTTHF 840
LHDPKVALES LYPLAKFTAE LGLSPDKAAE VLSQGAHLAA GPDSRTIDRF SPT 894
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR028424--HIC1
IPR011333--POZ_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB
PF00096--zf-C2H2
PF13912--zf-C2H2_6

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0042826--F:histone deacetylase binding
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030178--P:negative regulation of Wnt signaling pathway