dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0054143
Uniprot Accession Z4YJE4; Z4YJE4_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Obscurin
Protein Synonyms/Alias
Gene Name Obscn
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
7281SPRGRRQSPGKSPSRPhosphoSitePlus22135298
7285RRQSPGKSPSRSPSRPhosphoSitePlus22135298
7287QSPGKSPSRSPSRRSPhosphoSitePlus22135298
7289PGKSPSRSPSRRSASPhosphoSitePlus22135298
7291KSPSRSPSRRSASPRPhosphoSitePlus22135298
7294SRSPSRRSASPRRPGPhosphoSitePlus22135298
7296SPSRRSASPRRPGLLPhosphoSitePlus22135298
7370KTGSRGASPVREMTSPhosphoSitePlus22135298
Sequence
(Fasta)
MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE AGARFRLAQD 60
GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS EGTCAEQAPH FLLRPTSIRV 120
REGADATFRC RVGGSPQPAV SWSKDGRRLG PPDAPHVRVE EHGESSALRI RSARPRDGGT 180
YEVRAENPLG SASAAAALVV DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA 240
GTRTCTVTEG KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK 300
QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF QCEVAQPATE 360
AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY ICETTEGSRT VAELSVQGNL 420
TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR WLRNQEEMVA GGRVAITAEG TCHTLTIFQC 480
TLEDMGEVAF VSGGCRTTTQ FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP 540
VTIDGYVLEK RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE 600
FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK ASSIYVIRCD 660
RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG LPSSKLPAAA AREVLAQLHE 720
EAQLLAELSD QAAAVTWLKD GRELSLGPKY EMQVSAGRRA LLVRDVAQDD AGLYECVSRG 780
SRTAYQLLVQ DITDGYRDWG PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA 840
ALDTRQGKGT SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG 900
KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE PKLVFAKGQQ 960
AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK VRMEASGCSR RLVVQQAGKA 1020
DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE QQARSEVKAE AGASATLSCE VAQAQTEVTW 1080
FKDGKKLSSS SKVRMEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA 1140
KEQQARSEVK AEVGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ 1200
AGKADAGEYS CEAGGQKLSF RLDVAEPKLV FAKEQQARSE VKAEAGNSAT LSCEVAQAQT 1260
EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFHLDVTEPK 1320
LVFAKEQQAH SEVKAEAGAS ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR MEASGCSRRL 1380
VVQQAGKADA GEYSCEAEGQ KLSFRLDVAE PKLVFAKEQQ ARSEVKAEAG ASATLSCEVA 1440
QAQTEVTWFK DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV 1500
AEPKLVFAKE QQANSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC 1560
SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLAFA KEQQAHSEVK AEAGASATLS 1620
CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF 1680
RLDVAEPKLA FAKEQQAHSE VKAEAGASAT LSCEVAQAQT EVTWFKDGKK LSSSSKVRVE 1740
ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFRLDVAEPK LAFAKEQQAH SEVKAEAGAS 1800
ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA GEYSCEAGGQ 1860
KLFFRLDVAE PKLMFAKEQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK 1920
VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKLVFAKE QQAHSEVKAE 1980
AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC SRRLVVQQVG KADAGEYSCE 2040
ARGQKLSFRL DVADTRLMFA KEQQARTEVK AEAGNSATLS CEVAQAQTEV TWFKDGKKLS 2100
SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEAESQ IPERPSRREP 2160
LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA TSLGDTHTLT VRGAQVLDSA 2220
IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP VEGELGGTVM LVCELSPEQA EVVWRCGNTQ 2280
LRPGKRFQMT SEGPRRTLTV SGLREDDAEE YVCESRDDRT SARLTVKVPR VVKFTSGLSA 2340
MVAEEGQEAT FQCVVSPSDA GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ 2400
VTVEAEGASS SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE VKWTRNAAVL 2460
TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ AKLNVEMRQV RLVRGLQEVE 2520
AKEQGTASMD VELSHAEVEG SWTRDGLRLQ PGPKCHLAVQ GPVHILTLSA LQPQDSGLVA 2580
FRAEGVHTSA RLIVTELPVS FTRVLQDVVA TQKEKVTLEC ELSRPVDVRW LKDGVELRAG 2640
KAIGIVAQGT CRSLVIYRCE TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG 2700
EVKFVAENAE SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA QVRWFKGGVE 2760
LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT SAQFFVEEQS ITIVRGLKDM 2820
TVMEPAPAWF ECETSIPSVR PPKWLLGKTV LQAGGNVGLE QDGTVHRLTL HKTCSTMTGP 2880
VHFTIGKSRS SAQLVVSDIP VVLTRPLEPK AGRELQSVVL SCDFRPAPKA VQWYKDDTPL 2940
SPSEKFKMAL EGQMAELRIL RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE 3000
AMEEGRVCFS CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS VRQADTGTVC 3060
ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC EVSDPEARVV WRKDGVELGP 3120
SDKYDFLHKA GARGLTVHDL SHEDAGLYTC QVGSKETQSK VSVHDLHVGI TKRLKTVEVL 3180
EGESCSFECV LSHESPSDPA VWTVGGKTVG GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV 3240
FSVLGLTSKA SLIIRERPVD ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK 3300
SQKYDLLSEG TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF TEELADLQVE 3360
EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL TLKLTINALE RTDSDTYTCD 3420
IGQARTQARL LVHGQKVRVI EDLEDTAVQE GSSAKFCCRI APADYGPVHW FLDKTPLHSN 3480
ELNEITVQPG GYHVLTLRQL ALKDSGTVYF EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT 3540
EGEDLTLVCE TTTVDSSVRW TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE 3600
IGGASSSSIV RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR HGDDVLKSSN 3660
KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT VKTSSAQFVG KLRNKEATEG 3720
TTVTLRCELT KEAPVEWKKG TETLRNGDKY SLKQDGAVCE LQICSLLVAD AGEYSCVCGQ 3780
EKTSATLTVK ALLVHFVRRL RSKEATEGDT TTLQCELSKA APVEWRKGTE TLRDGDRYSL 3840
KQDGAVCELQ IRSLTIADAG EYLCTCGQEK TSATLTVRAL PAKFKDSLKN EEATEGTTAT 3900
LSCELSKAAP VTWKKGPKTL QSGDKYVLRQ DGAVCGLQIH GLTMADAGEY SCVCGQEKTS 3960
ATLTVRGLPA KFIEDLRSQE ATEGATAILR CELSKAAPVE WRKGSETLKD GDRYTLRQDG 4020
AVCELQIRGL AVVDTGTYSL PTKFTEGLRN EEATEGTMAT LRCQMSKAAP VEWRKGSETL 4080
RDGDRYSLRQ DGAMCELQIR GLTIEDSGEY TCVCGQEKTS ATLSVKALPS RFIEDLRSQE 4140
ATEGTMATLR CQMSKTAPVE WKKGSETLRD GGRYSLRQDG PVCELQICDL AVEDAGEYSC 4200
VCGQEKTSAT LSIKALPPRF IEDLRSQEAT EGTMATLRCQ MSKAAPVEWR KGSETLGDGG 4260
RYSLRQNGAV CELQIHDLAV EDTGEYSCVC GQEKTSATLN VKALPPRFIE DLRSQEATEG 4320
TMATLRCQMS KAAPVEWRKG SETLRDGGRY SLRQDGAVCE LQIHDLDVED AGQYSCVCGQ 4380
EKTSAVLTVD ALPTRFTEEL KSKEFMEGCT ATLQCQLSRK ASVEWEKGTE TLRDTDRYKL 4440
QQKGAMRELQ MYSLAMLGAG EHTCGGGGGA KITAMLTVRA LPPKFTEGLK KEEATEGTMV 4500
TLRCQMSKEA TVEWRKGAKT LSDGGRYSLR QDGAMCELQI CGLAVEDAGE YSCVCGQEKT 4560
SATLSVKALP PRFIEDLRSQ EATEGTMATL RCQMSKAAPV EWRKGSETLR DGDRYSLRQD 4620
GAVCELQIRD LAVEDAGEYL CVCGQEKTSA TLSVKALPPR FIEDLRSQEA TEGTMATLRC 4680
QMSKAAPVEW RKGSKTLRDG DRYSLRQDGA MCELQICDLA VEDTGDYSCV CGQEKTSATL 4740
SVKALPPRFI EDLRSQEARE GTVATLRCRM SKAAPVEWRK GSETLKDGDR YSLRQEGNLC 4800
ELQIRDLAVE DTEEYSCVCG QEKTSATLSV KALPAKFIED LRSQEAPESS TVTLRCKLSK 4860
KASVVWKKGS ETLRNGARYS LRQDGAVCEL EIRDLTVEDT GEYSCTCGQE RTSATLSIMA 4920
PQVVFQQPLQ NLQAEEGSMA SLRCELSVPN AAMVWSKGGL ELQGDTRREA RQQGCVAELL 4980
LRDLRREDAG EYSCTCGSQT TSATLMVTAA PVRFLRELQA QDVDEGATAR LRCELSREAV 5040
SVEWRKGSLQ LFPCAKYQMV QEGTTAELLV HGVEQEDAGE YTCDAGHTQS IARLSVRAPK 5100
PKFKTDLQST EQEAGGTARL CCQLSEAEPG TPVQWLKEGV ELHVGSKYEM RRQGAVCELL 5160
IHGLEAKDTG EYACLVGGQK TLASLRVKEP EVTIVRGLVD MEVQADEDVE FTCKVSQAGA 5220
TDVQWHLQGL PLQSNEVTEV AVLADGCTHV LQLKGVTLED AGTVSFHVGG LSSSAQLTVR 5280
GDRSGAPEGC AAQRGPGCPL PVPTVQGLGP GGSLGFGRGS LAVQRDERHH CGAGHTLPAH 5340
SAQGDPGGCW DHHSPSGLML LRGPAEGHSK NTVLRGLENV DALEGGEALF ECQLSQPEVA 5400
AHTWLLDDEP VHTSEKVEVV YFENGLRHLL LLKNLKPQDS CRVTFLAGDV VTSAFLTVRG 5460
WRLEVLEPPH DASVKAGMQV RFTCILSEAV PVGEATWYIN GAAIQPDDTD WTVTTDGSHH 5520
ALTLSNAQPQ HAGEVTFAAR DAVASARLSV LALPDPPEDA EVVGRSDHSV TLSWVAPMSD 5580
GGGGLCGYRV EMKEASTGQW QLCHDLVPGP ECVVDDLVPG KTYRFRVAAV GPAGAGEPVH 5640
LPQMAPAPAP APAPAPAPET RQAVVGEDIC LELEVAADGG EVVWHKGTER IQPGGHFEVL 5700
SRGQRQMLVI KGFRTEDQGE YRCGPIQGLP SSGAATFNVV MTSGSGDEVP AQPSLPPEAA 5760
QEGDLHLLWE ALARKRRMSR EPTLDSISEL PEEDSRVQHL RQEAEETAPD LSEGYSTADE 5820
LARTGEADLS HTSSDDESRA GTPSLVTYLK KAGGPGISPL ASKHEAQVTT SVKPQKQQEP 5880
VVPTCPPPGD LSAADLMDPS LDKAAVKIQA AFKGYKVRKE MKQQEGPVFS RTFGDTEAQV 5940
GDVLRLECVL ATKTDMRACW LKDGIELTDG RHYHIDQLKD GTCSLLVTGL APTDSGRYTC 6000
QVSTKSGRVS HSACVVVSGT ESEAESSSGG ELDDAFRRAA RRLHRLFRTK SPAELSEEEL 6060
FLSADEGPGE PEEPADWQTY REDENFVCIR FESLAEARQA VTCFRNMFAT MGIGVEISLG 6120
EQGPRGVEMR IGKVAPTVTP AVPLAKTPGL QTSDAAPVFL TELQNQDVQD GYPMSFDCVV 6180
TGQPVPSVRW FKDGKLLEED DHYMINEDQQ GGHQLIITAV VPADMGVYRC LAENSMGVSS 6240
TKAELRVELT STDYDTAADA TETSSYFSAQ GYLSSREQEG TESDEGQLPQ VLEELKDLQV 6300
APGTRLAKFQ LKVKGYPAPK LYWFKDGQPL TTSDHIRMTD KKTLHTLEIV SVTREDSGQY 6360
AAYISNAVGA AYSSARLLVR GPSEPEEKPA SDVHERLVPP RILEKFTPKK VKRGSSITFS 6420
VKVEGHPAPS VHWLKEEAEK GVLWIGPDTP GYTMASSSKQ HSLVLLDVGR QHQGTYTCIA 6480
TNPAGQALCS ASLHISGLAK EEEQERVKEA LISSFLQGTS QAVSAQMSES AGFADLVGQS 6540
KGESLVAEEA HSHLSLAEVG TEEFLQKLTS QITEMVSAKI SQAKLQVPGG DSDEETKTPS 6600
ASPRHGRSRP SSSVQESSSE SEDGDSRGEI FDIYVVTADY LPLGAEQDAI ILREGQYVEV 6660
LDSAHPLRWL VRTKPTKSSP SRQGWVSPAY LDKRLKLSPE WGPTEAPEFP GEAVSEDEYR 6720
TRLSSVIQEL LSSEQAFVGE LQFLESHHMK HLERSPRVPA AVASQKTVIF RNVQDISHFH 6780
SSFLKELQGC GTDDDVAMCF IKNQEAFEKY LEFLVGRVQA ESVVVSTPVQ EFYKKYAEET 6840
LSAKDPTQPP PPPLQHYLEQ PVERVQKYQA LLKELIRNKA RNRQNCALLE QAYAVVSALP 6900
QRAENKLHVS LMENYPGTLE ALGEPIRQGH FIVWEGAPGA RMPWKGHNRH VFLFRNYLVI 6960
CKPRRDSRTD TFSYVFRNMM KLSSIDLNDQ VEGDDRAFEV WHEREDSVRK YLLQARTVII 7020
KNSWVKEICG IQQRLAQPVW RPPEFEEELA DCTAELGETV KLACRVTGTP KPIVSWYKDG 7080
KPVEVDPHHI LIEDPDGSCT LILDNLTGID SGQYMCFAAS AAGNASTLGK ILVQVPPRFV 7140
NKVRATPFVE GEDAQITCTV EGAPYPQIRW YKDGTLLAPG NRYRMLNEPR SGVLVLVIQA 7200
ASKEDLGHYE CELVNRLGST RGGGELYMQS PALRARDQHH REQIVAAVEV TEQETKVPKK 7260
TVIIEETITT VVKSPRGRRQ SPGKSPSRSP SRRSASPRRP GLLAPERLYP PGTSPSRRLE 7320
VEQGRKAPVP ALYVTEAEVH APASQSQPKW LEVEETIEVR VKKTGSRGAS PVREMTSRGE 7380
GILFTLPGGI PGRDPNANNS NNKSVYQEAR TWGPAVVHVG EPFIFQVDSV GNVDWVAASP 7440
EPEQVRASQK EENTERQEGC SDGDENTFLM EEPQDTDSLQ GRDPKILTHN GRVLTLADLE 7500
DYVPQEGETF GCGDSTPSTP DEPPCEVSVL QREISEPTVG QPVLLNVGRP PGTGATPSFF 7560
RPGSQVHSPE SVSFLLREAW SGPVSAAPWT SSFHTHVQSS VDGSHGSFKT EVSTQTVSFG 7620
AVGETVTLHI DPDGGEAPGP SQG 7644
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR000219--DH-domain
IPR003961--FN3_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003599--Ig_sub
IPR003598--Ig_sub2
IPR000048--IQ_motif_EF-hand-BS
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50010--DH_2
PS50853--FN3
PS50835--IG_LIKE
PS50096--IQ
PS50003--PH_DOMAIN

Pfam

PF00041--fn3
PF07679--I-set
PF00612--IQ
PF00621--RhoGEF

Gene Ontology

GO:0005863--C:striated muscle myosin thick filament
GO:0030018--C:Z disc
GO:0030506--F:ankyrin binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0031432--F:titin binding
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0035023--P:regulation of Rho protein signal transduction