dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0054130
Uniprot Accession X5M5N0; WNK_CAEEL; H2L282; H2L283; H2L284; H2L285; H2L286; H2L288; H2L289; H2L290; H2L291; H2L292; H2L293; Q18657; Q8I127; X5LPT1; X5LPT5; X5LV40; X5LV44; X5LX64; X5M5N6; X5M8T1; X5M8T5;
Genbank Protein ID NP_001255367.1; NP_001255368.1; NP_001255369.1; NP_001255370.1; NP_001255371.1; NP_001255372.1; NP_001255373.1; NP_001255374.1; NP_001255375.1; NP_001255376.1; NP_001255377.1; NP_001294032.1; NP_001294033.1; NP_001294034.1; NP_001294035.1; NP_001294036.1; NP_001294037.1; NP_001294038.1; NP_001294039.1; NP_001294040.1; NP_501603.3; NP_872075.2;
Genbank Nucleotide ID NM_001268438.1; NM_001268439.1; NM_001268440.1; NM_001268441.1; NM_001268442.1; NM_001268443.1; NM_001268444.1; NM_001268445.1; NM_001268446.1; NM_001268447.1; NM_001268448.1; NM_001307103.1; NM_001307104.1; NM_001307105.1; NM_001307106.1; NM_001307107.1; NM_001307108.1; NM_001307109.1; NM_001307110.1; NM_001307111.1; NM_069202.5; NM_182275.4;
Protein Name Serine/threonine-protein kinase WNK
Protein Synonyms/Alias Protein kinase with no lysine 1;
Gene Name wnk-1
Gene Synonyms/Alias C46C2.1;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)		 Serine/threonine-protein kinase which phosphorylates gck-3 (PubMed:18049475). Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3 (PubMed:23076791). Essential for larval development and the tubular formation of the excretory canals (PubMed:18049475).
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
1076TPPTRDASQEPNNVQPhospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 21081558; 19060867; 18806794
1091VTNVRKVSQESNAESPhosphoPep 2.019060867
Sequence
(Fasta)		MPDSITNGGR PPAPPSSVSS TTASTTGNFG TRRRLVNRIK KVDELHPAQE NPTMGSHWLS 60
EQERSRLEAV QQDWRRTRPM KFQWTSKKRP DDPTTSSPST VSISNALENS TPSLNNVSSI 120
TNSSSPFSLS SAATSTASAI IPFTSNVATN HPHLNHHVSR IPQAIVTGGT NGSLPPLLIS 180
PTSAAAATPL ISGKAGPMSP STGSPINVAA TVLQNAVSSP QHSIFDRSRL NKIPPNTSLA 240
SSSSPSDAAN NDKPIQQRHS ILSNVRTLTQ AMVNDGPRTL TGDDMDKMVS EEERARKEQE 300
KREEEEKAAR RIDVEDDFDA QEKPIDKSKN GRFLKFDEEL GRGSFKTVFR GLDTETGVAV 360
AWCELQESKL NKTERQRFRE EAEMLKDLQH PNIVRFYDYW ESADLCGKRK YIVLVTELMT 420
SGTLKMYLKR FKRINIKVLK SWCRQILKGL SFLHTRNPPV IHRDLKCDNI FITGTTGSVK 480
IGDLGLATLK NKSFAKSVIG TPEFMAPEMY EEMYDESVDV YAFGMCLLEM VTGEYPYSEC 540
MNPATIYRKV ISGVKPECFS RIPAQYPEIR EIIDRCIRVR REERSTVKQL LVDDFFTPED 600
LIGIRVEIKN RDADLNDLNV EIQMQLRVYD EKKRKQYRFK ENEGLQFAFD IENDSPDEVV 660
QQMIEQQHIP DEDTRMITKL IKDKVDAFRR DRDHRLLEIK RAKEEEERIR EEAEIKEELR 720
LRAEAKEKEK ERLEKERLEK KAAAAAAANP NPTPIPPTPA TPHSSAQQQP IPPPLSTQTS 780
AEIQQSAQQP SVPVTMIANI PAMSPTSAQP QPVLSPTSAA VPVPTTMIHV PKPSEIPVQN 840
VATTAAPVAA NNVPPSPAPF KTEDIQTPTL AQNTVPRTIS TDASGLVINT PASIASPSPA 900
PSATDVASTT APVTPAPTPT TTTDGGAAAA STTTENKEEK RKSNKRKVVM EILGCDESRN 960
FALVSCRLDT SHKSVTFQFA PGTDKPCTIA TKLLAEDCLL KVHVHIVEAQ LGEVIQLINS 1020
DGKKGVGTKL ATVLDPNSTE PPTITAVMPK DSSAATASNT KPKIEIEKTP PTRDASQEPN 1080
NVQVTNVRKV SQESNAESVQ SIPRPGGIIV MSPTNQTDSA PPPTGAAAKP SRFQVTKSAD 1140
PIATPISSSI STATVIPIVA ATPTNITSEP VIVQPITAQV ITHLATPSPV SHSLSSNSSP 1200
SATTHSNMSS IQSTTSVPGR RFTVQPVSQA ESGISSSIST PHPEPTPAIT SCPPPVPSVP 1260
PVVSNGTLNL EVAPKQTPSA TNQNVDTQHS SSTASTATLV SETPATVHVT PISVPAPVQE 1320
PLVIDHHSDV LTQLDSELRK CFQVSGVSHS ASPSTVVESL TSMTPQTIPL ACQTVPASIG 1380
QAPAVIAAAH AASLIPNASV PQSPSRLDAE TGLAGLHEKL EALKMEQDRR EDMGDDAIGT 1440
TTTDGKDEIP IDTLKGLAEA LGKVIHADGR ETTPMPPDHP DLTDASTQQL ISPSNPDVLT 1500
TMSSAVEGSA SSTMIEDIDA STSAVDASMM NSMPPGAQNS TDQIPAAMTL SMDQECAQSM 1560
TSSITRNTTG TKLATFENLE TALSSTLGTH IRQPNAPSSR DETTAPMTPS FTNERIGGGG 1620
GGGATSFSIG TPPSHSPFPV SECDYDLKGQ MDLESEDPEV IQMIVRHRME QHKLLEKQRV 1680
EIERLRSKIR VPRATSVNPE MIGDDEADTT LTALQSALGN ASLSLPASPP PNTEIPDNEG 1740
QHHCNSFRCI GDPNDNVSIV NQIKQRLGII PSSRQSVRSA TSSSPSTPPS SSSAPPKSLS 1800
SPTKSYVSHC SLSIGYGSTA SSEQQQREPS PSATTSSFLS DPATGVIENV 1851
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR024678--Kinase_OSR1/WNK_CCT
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF12202--OSR1_C
PF00069--Pkinase
Gene Ontology

GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007275--P:multicellular organismal development