dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0054106
Uniprot Accession X2JC00; X2JC00_DROME;
Genbank Protein ID NP_001284725.1;
Genbank Nucleotide ID NM_001297796.1;
Protein Name Rho GTPase activating protein at 1A, isoform E
Protein Synonyms/Alias
Gene Name RhoGAP1A
Gene Synonyms/Alias CG40494;Dmel_CG40494;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 29 (View all)
PositionPeptidesSourceReferences ( PMIDs )
121SSLNLRESPSSTGAKcurated22817900
134AKDKDRLSLNPDNKYPhosphoPep 2.019060867
233IDKPLRKSTSQYVTVPhosphoPep 2.019060867
234DKPLRKSTSQYVTVIPhosphoPep 2.019060867
286EATAPPLSPSLTSYAPhosphoPep 2.019060867
326IPSQQLSSSPKRETYPhosphoPep 2.019060867
327PSQQLSSSPKRETYMPhosphoPep 2.0;curated19060867; 22817900
369SDILRQKSSDNLDSKPhosphoPep 2.019060867
450GRTGVGASPTGSLSKPhosphoPep 2.019060867
456ASPTGSLSKTGKLAMPhosphoPep 2.019060867
468LAMADSSSTSSLERRPhosphoPep 2.0;curated19060867; 22817900
471ADSSSTSSLERRSCLPhosphoPep 2.0;curated19060867; 22817900
489DADIGTESRESGANQPhosphoPep 2.019060867
492IGTESRESGANQRSVPhosphoPep 2.019060867
498ESGANQRSVGSKESLcurated22817900
501ANQRSVGSKESLTSQcurated22817900
504RSVGSKESLTSQGIScurated22817900
506VGSKESLTSQGISEVcurated22817900
520VQIKSYESVSSLSSEPhosphoPep 2.0;curated19060867; 22817900
523KSYESVSSLSSESAKPhosphoPep 2.0;curated19060867; 22817900
Sequence
(Fasta)		MSVFDDFQRL WMQRFPQSSL SDAWEQDVRA SLERHKVRIN ELSKELEQET LYVEYLERLL 60
SDVERYRVSG GDPKALFEAA SGSCASSNNS NCSSTTNGAT QEESNTNLDK DFKSSLNLRE 120
SPSSTGAKDK DRLSLNPDNK YTTHTNAVIG GIGSEKVSGP LHSTQITADG KRTGELYLKR 180
EEDKCKDSNS EDTDGALQQC ITELAASLKA QPDNVAGGRL ENDVDIDKPL RKSTSQYVTV 240
IQVKEAKDKE SADGTTSSSG IGEPQQQPTP PSTFSRYSEA TAPPLSPSLT SYAAHVEAKK 300
KMPPRPPPKN IRRVEPPTIP SQQLSSSPKR ETYMINTMPS SSSGSLCIDS LGNSLERNIK 360
PSDILRQKSS DNLDSKYSAK RKTTPELSKF VNVNNPELME ELGRKMVSKA DSLEQTRRND 420
SSPSGCGSLG RTSSTPGRSL TPGRTGVGAS PTGSLSKTGK LAMADSSSTS SLERRSCLQA 480
VDADIGTESR ESGANQRSVG SKESLTSQGI SEVQIKSYES VSSLSSESAK AVASQQSAAA 540
GGALAECEPY YDSVPLDNGD GEYVFIKPGR TGSSSSRDDL STPGSSILPL PNVADPESPG 600
RTSNYVNIDF FLQQGIETRS SSLDSDGEYE GPPILRTISH DDQTTTQTTP GAIRKNLVSA 660
ILVCGNARGA KIRSILSSII QSETIYVECL NKMMQYKKAI HATLTTSQPV IREEEENTIF 720
FKIDELYDLH TGFLSDLKTI VSHEGGDVLI GEPFRRLAEM FDLYSAFLHN YKNAIETVKK 780
CSANNPQFKK IVSTIVLNLQ TEQSLTLEDL LHKPVARVQI NALVFNDLLR ETPNAHPDHQ 840
PLRQAQKIIQ MFLNQFNVVN QRLPIESNRN LRRMVRNSFI VELVDGHRKL RHLFLFNDVI 900
ACAKYKALGR DRIDYELKWF IPLKDVSIYE EADPAVELKE SSPANISQVK RNLRSVRDQL 960
AMEVANSGSG AFRSGDKYRR KLADLESQLV LATPNLVLRL GNKANNKTIT FFLSSDFERT 1020
QWIDSILSLK QKCNLPGANT INSLEVTAFI VAMQKGMKTE MGSYLMRNTN DESLLVGDLY 1080
MGVHGLEGLE QANDLYICVE VDSYGHYFRK ATTKKICRSQ TPLWNESFML ELEGSQNVRI 1140
LLYEAKERPL LKAKHILKLS LSWLTETTQP KSIKLTETLE LGCSFRFIPG ELFRGSTKPG 1200
ALFGAKMSQV LKREKRDIPF IIGACIREVE RRGMLEVGCY RVSGSASDLA KLKKAFESDA 1260
YEAEQLLREV DIHSVTGILK TFLRELPEAL FTDQLYPRFF DTFSAFSNNN ESTRINELLK 1320
VFEELPQANK ASITSILDHL IRVHEKETDN KMSLHNLAMV FGPTLLRPGQ TQVKQKDPLA 1380
ASTVDVMAQA GILYCFLQAR IKKD 1405
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0343--GTPase activation
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR000008--C2_dom
IPR000219--DH-domain
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
PROSITE

PS50010--DH_2
PS50003--PH_DOMAIN
PS50238--RHOGAP
Pfam

PF00620--RhoGAP
PF00621--RhoGEF
Gene Ontology

GO:0016020--C:membrane
GO:0005096--F:GTPase activator activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0007030--P:Golgi organization
GO:0045792--P:negative regulation of cell size
GO:0043547--P:positive regulation of GTPase activity
GO:0035025--P:positive regulation of Rho protein signal transduction
GO:0007165--P:signal transduction