dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0054066
Uniprot Accession U4PR86; MELK_CAEEL; A7WK47; A7WK48; U4PB44; U4PBH9; U4PED2; U4PLZ7; U4PR90;
Genbank Protein ID NP_001023420.2; NP_001023421.2; NP_001294353.1; NP_001294354.1; NP_001294355.1; NP_001294356.1; NP_001294357.1; NP_001294358.1;
Genbank Nucleotide ID NM_001028249.3; NM_001028250.2; NM_001307424.1; NM_001307425.1; NM_001307426.1; NM_001307427.1; NM_001307428.1; NM_001307429.1;
Protein Name Maternal embryonic leucine zipper kinase
Protein Synonyms/Alias
Gene Name pig-1
Gene Synonyms/Alias W03G1.6;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)		 Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants (PubMed:16774992, PubMed:20929735, PubMed:23946438, PubMed:23267054, PubMed:23851392). Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface (PubMed:22801495). May act downstream of par-4/strd-1/mop-25 to regulate cell shedding (PubMed:22801495).
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
357QNILCSPTIHASLENPHOSIDA;curated21081558; 18806794
411SRFVKPMSPAAEKDKPHOSIDA;curated21081558; 18806794
522PTLRGLFSPGNAEHKPHOSIDA;curated21081558; 18806794
584RLPQRVFTSLERKKEcurated18806794
585LPQRVFTSLERKKEKPHOSIDA;curated21081558; 18806794
Sequence
(Fasta)		MSKYEVLQGF YAVHDELGSG GFGKVRLATH LLTNQKVAIK IIDKKQLGHD LPRVQTEMDA 60
LRNLSHQNIC RLYHYIETED KFFIVMEYCS GGEMFDYIVR KERLEESEAR HFFRQLVSAI 120
AFVHSQGYAH RDLKPENLLL TEDLHLKLID FGLCAKTEKG RIDKHNLDTC CGSPAYAAPE 180
LIQGLQYKGN EADVWSMGIL LYTLLVGALP FEDDNMQIMY KKIQSGCFYE PEFLSPLSKQ 240
LLRAMLQVVP ERRISVKKLL EHDWLNHKYT QPVKWNTIYD KNFIDRDVAR VMSKYYGFES 300
TDKMIEKIKE WNFDYMTSTY YALLHRKRNG MEIILPMVRN STNTAPPNVQ NILCSPTIHA 360
SLENNLDKSG LEDDDSDPSS ISSSSDISAR LKKNCVVSDE SSSSRFVKPM SPAAEKDKKM 420
SYVNAMLTMP SQFTGRSPLR IPESPMSVRS SDSASLGSAA TPSRGGVKDN DKENASTGKN 480
YRMGASTCKS RGPLKITGVE EGTMKSVYTT PNTRPTLRGL FSPGNAEHKK RQRARSSDRA 540
SIGMPPGSPV SIGSAHSANN ELLADGRTPR SRIKTNRLPQ RVFTSLERKK EKLITLLTPR 600
KMQRDSPQVL KDVKNMVNVS MTASQDPEEV RNLLKKVFDD ERMRYELNGW KFLATQETVH 660
GWMTVELEIV RLQMFDKVGI RRKRLKGDAF MYKKVCEKIL QMAKIE 707
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0418--Kinase
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF02149--KA1
PF00069--Pkinase
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0006915--P:apoptotic process
GO:0055059--P:asymmetric neuroblast division
GO:0031581--P:hemidesmosome assembly
GO:0035556--P:intracellular signal transduction
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0006468--P:protein phosphorylation