dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0054057
Uniprot Accession U4PBY0; U4PBY0_CAEEL;
Genbank Protein ID NP_001294472.1;
Genbank Nucleotide ID NM_001307543.1;
Protein Name Enhancer of EfL-1 mutant phenotype
Protein Synonyms/Alias
Gene Name eel-1
Gene Synonyms/Alias CELE_Y67D8C.5;Y67D8C.5;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
788MARSVVFSPNNSSLLPhospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 21081558; 19060867; 18806794
2391VAEEEEGSETYEEREPhospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 21081558; 19060867; 18806794
3728AEAKRKESQAASSSAPhospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;curated19530675; 21081558; 19060867; 18806794
3732RKESQAASSSAAAAVPhosphoPep 2.019060867
Sequence
(Fasta)
MKIDDAEPSS SSSGSDMPPA SATLLRNIVA TKNDEDFIAA INKGREVHAV MGKTELYKWT 60
EVLNRCDEIL EKAVHKNEFG NLQCDHDTVL KNHAVAIVRF TVLLFECTSS RRIYKSVDRI 120
LALLESTDMD LLAEVLRLLQ VMGKRSKFLS TRIPQKEQHA LAQRLTAIAQ CWGGKLRTVK 180
MAECLKREPK LPMLFPFTYT DAKQRTIIVE QPKFQKDESV GELITRTVAQ ISPPVSSDSV 240
PSQQFSKEDL YCLLSRVRML VTFEDWHHRF KCLIVRLLSV STLVYCRLGG TDETTLSSLL 300
YSGFIEEIVE MLKSDREADT QQDHNLHDAI QTEALSTLCS IVTYEKEPKI TQILEALSAG 360
SYHGFLSVMT RQIVDELKSN NLGKTGKPSV SLATALFSFI YHLASIEPGG DTLVGSGLTQ 420
TLLSVIGFHE LPIECITFGT RCARIIDLFT TIDVTSFKAN NGMEICVNRV VHEINECRKE 480
QPFMIDISYD MPFEEEPEPR DDQEAHEEPE DESDERNPVD QEAPVPIEVD APLPPASPIA 540
APAPVPVASA STSSDSKIKG GPWEEVQMNG ATCHQQRSGL IKGLLTFIKR AIGDVQFQDI 600
MKHLMEGDLP EALMHILSNA EYYSPSLFHQ SAHLITNFVY QFPEELSSIQ RRHVPYVIFQ 660
SLLRKELPNS KDVITTLGNV FTAMCLNERG LRQFKSYDPF NQIFRIVLSV KFLVTLRKKR 720
SAEVFESAQA IGGALDDLMR HYPDLKHDML KSIIVILDLL DEIGRNPPAG VELVPTLTKT 780
MARSVVFSPN NSSLLPREAR EARELRIQQL QREIPEQADE RVGGDVEEEP MEVEDAEDSD 840
VDEEDNEMSM DEMSGEAPAP PAAPSPKPTK PFEYGAGMMC EDANGKKILP IGDYMLLIAR 900
VVETMMTQSP SQKITEEFID ECVMQKIMKL CHLPCITNEA THATYIGSIA NIIKHIVKAG 960
YQSQRNGPDV GPKLMSAIVG EFIKTINPLF EVNNGDFSAM NQAESRKATL LMHLDEKLVE 1020
KTLVELNSII PTLLNLNKSP MSSTYNPQDH RTRIYETWKM PEGMKLYGML RKLSRMLCWE 1080
YELVQTLKPT IRTAATQTEG EMLSDQPADT HLDVEVMPPW DEDSVDEQQK RDEAKEPRWK 1140
AAGVSQEEHD FWIKNKPLQD IVSKSHAMVK DLLNSMGKTI NVNNPRRPRI RDTPPLPLAA 1200
SHCISMIFSS IYKDLKWEPP VQNAATSPMA YGRYIELLTQ LNHSLFENGR CSNPALPQNF 1260
YTSGCHKAFF ELFSDKIIPF LGDNMPEGVE QTMEEWCRLA VKLTDRNTIV SSDNWQRRDR 1320
QSADFDTNKY LKLVCRDMFN AYKQFFEKMA QMPDWELKSL KKVCENAFSV FKEVAKNLVE 1380
ETEATTAATE AVNAAAAPAP ADAPAAEWGP GALRIPPVAV EPAPAPVAVN PAAAADPHED 1440
TIVMLMDLGF SRDIVLYALE STRNADEAAN YLLAHGNEIP LQDAANPFRD DLLNQVLREA 1500
GAEMIAGANT PNADEIELQL NAQFAEHQGY ELVRIAQRVL RDAGAEQIGL QIMEAYPDES 1560
VDVAAEQLIN DVMDRVRNPR SSYEENIAQP LIPPLSQLKI EQDVSLNSAC KQLFPLVKRL 1620
LLVSNDTIHP CAELIVSIFP AMTEEWRKEH LIAEICGEDL KNMAKSLVEQ EVDENGRPKQ 1680
HDVARTMTNR LHFAVLIFDK ISEEYVQWID ANGMTEVMLT SLEYLVERFK SVDYYQSLIT 1740
RIICWNDFYA KTHRLIVRRA YLKSLSPSLV WSYQSYEEDA LRRRADYSSG EKKWVPYDAA 1800
SQKTLNDAFF AGVRGVKCTL KRGVRPNKKV DVDFASMKQG DGTSRENIKA ELPPTVEVSI 1860
PDLMDAEAKL SWSEDQNDRF LDLSTQILRT GALDPKCSHS MLSFIARLTR SHRNAVRFME 1920
KDGVEAILRL RARCAITYPF LVSIIIRNCI DDDALLGHIY EKTIRGYIAV PTQPPASMSE 1980
YAAGKSKDFA DTLNFMAPLS TRNPLVFTEA MNKLARMNGS LILPMIKEKK PTLSVSSTAG 2040
GASTSSSSAP PPPPPLTSSS SHTVVENNSR AEKIVSMMLS EVLNGEFPTV GQTRMLSQEK 2100
ILQILAEIVK SYPSLAIIIA ETQAEGRSAL HSLIDTYIIA PIEKIETTNA LKTLIAVISA 2160
SQNSLKAQEL LVLDVKNALA SYSEKASELR VDLAKLQLDK ESEEREEATT SLKKQETEVL 2220
SKISELCSII IIMCQSCPAH HHHHHSSTDR NNRERSSQNA IMKMFHKKRM CADLVKTIHC 2280
LQLSTKVSLD TVNQILKTLD TLLEGSTTTT SATITGPRSL MDIVAGRREQ RREAAAGGIM 2340
NEREIDTIFQ RDGLAFDGEM ENLLRRLQGD HWRGNSVQRG AGQVAEEEEG SETYEERERS 2400
DSPSESSEHA GDEEVRDDAV ETGDGEVDMA DAQDAPLAAP DAPPGINLVD EIMQQVQRDV 2460
EDDEEDEDGD QNEHEAEEDD HDREDEDDED DDDDEDEEEE AEDDDQDEDD VRHVEQNPEP 2520
LARRLFEEDD DDEEDDDGDE DGDSMEDDVQ RLDLDDDYFD MGGPFDAQRM DDMIFPPSFG 2580
RPAVTSFADL FRDDFDFLFS RPPYRAERRP LARGSHLGGV ISEHPLMTRP PAENDVSRRP 2640
NTNIRAEILQ MHTRSSLHRQ NAIRRTTTEA RELEAISRGI RMGELPAGRM LVRGTTTHGD 2700
GGVHTSFFDH IFDIRPSNVA FSRSGAYRSY NTGDRDERRD IRASQVPTCL ERLESYSLSM 2760
EPVSSRFVTV IVNSHLNKIH AAREAQIKKE AEIKAKAKKD AEAAKKAAED KKKAAEAPAP 2820
APSAEQSDSP ASPDAPAPAP EEIGLATPAA TNTTNTVSES VAPNASTRGD DTLTTPAAAQ 2880
VEDQASEDQH IEEEPMEVGE DDGAAEAPQS SAATAASSVA GTEEIEDVER QAVEDHVPEI 2940
QDNDDTLPYE GAVEHAPAQA PEENVMPEEF RAILGDIIIP DGVDPAFLAA LPEEMRAEVI 3000
RDYQRQQRAE RASRPVPAAQ PVAVNPNAPA GGEAAQGEGQ AEQPAAAVVP LVEPIDPVFL 3060
NALPPELQEE VLAEHERRLR EAEEQQRRQN APPAPVVEMD GAAVIASLPA NERAQVLAEM 3120
DDAELAGLPA DMQNEARRAR AQHVEPNMLR YHRLLFRGGV GGAPGAIGTV RARTNARAAA 3180
NAGPSVGQNA GNAIQAPPDQ PHLLDRESIL TLCLLYLVDN NRVPHTRLQK VLRSACVNQT 3240
TCDFIVWCLL ALLDKASEAN TDDEEILSNV PAWLDSIAVS GVGHNERAIR ISENAQKISI 3300
HSMLAIPMCK NILDLLANIA RAYPGNFLPL ILRHGAKPTD TPKQAPSFAQ FWTMVQNTTK 3360
VPKSKDWTAT PEQQLEECPL GQMLNSLRKP IMAKSPLKEK VLKVASQIMV TLPMDTLKLL 3420
GNDESRKPLA EKLEFVIQVM TTGSCSTEGL ADGLTILSEA MRSLSDSTSV DIYEHLFLAV 3480
SKLGGELLPQ VDRLIVELDE AQKKEEVSSV APSDQPTSSK TAQLVVDTSA AGRVATGRFD 3540
GERLVIDGDQ NMRLQMSSCK ELQLPAVTVL TDKGGAQYAL LSALQTLVKV RNHMKAIRKD 3600
KAKRAKDAEK KLKEKETPST SAPAAPAAPA TAPTAPAAPD APVENNEVPE PAAELEEVND 3660
EEPRISERLS SLESLWNSLS ECLLRLGKAS DPHAVLALQP AAEAFFLVHA SQQNKLKAKD 3720
AEAKRKESQA ASSSAAAAVA SSVSHDGLRE DLDPDTAKLI EFAEKHRQVL NQALRQNNAV 3780
LSAGGPFAIL TQFPKLLDFD VKRKYFRKEL TKLEPSNSRM PRYRRNDVSV QVSRNRVFSD 3840
SFRELFRLRP SEWKNRFYII FQGEEGQDAG GLLREWFSVI TREIFNPNYA LFITAPGDMV 3900
TYMINKASYI NPEHLDYFKF VGRLIAKSVF EHKYLDCYFT RAFYKHILNL PVRYQDLESE 3960
DPAFFKSLDF LLQNPIDDLA LDLTFSTEVE EFGVRSVRDL KPNGRKIEVN DANKDEYVKL 4020
VCQMKMTGSI RKQLDAFLTG FYEIIPKDLI SMFNEQELEL LISGLPTVDI DDMAANTDYK 4080
GFQKTSTHIQ WFWRALRSFE KEDKAKFLQF VTGTSKVPLQ GFASLEGMNG VQKFSIHMDS 4140
RGGDRLPAAH TCFNQLDLPQ YESYEKLRQS LLLAIRECTE GFGFA 4186
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50237--HECT
PS50030--UBA

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0016567--P:protein ubiquitination