dbPAF Protein Information
| Tag | Content | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0054029 | ||||||||||||
| Uniprot Accession | S4R2P9; NAC3_MOUSE; Q7TS90; Q8VHJ8; | ||||||||||||
| Genbank Protein ID | NP_536688.2; | ||||||||||||
| Genbank Nucleotide ID | NM_080440.3; | ||||||||||||
| Protein Name | Sodium/calcium exchanger 3 | ||||||||||||
| Protein Synonyms/Alias | Na(+)/Ca(2+)-exchange protein 3;Solute carrier family 8 member 3; | ||||||||||||
| Gene Name | Slc8a3 | ||||||||||||
| Gene Synonyms/Alias | Ncx3; | ||||||||||||
| Organism | Mus musculus(Mouse) | ||||||||||||
| NCBI Taxa ID | 10090 | ||||||||||||
| Functional Description (View all) |
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain (PubMed:14722618, PubMed:21593315). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:14722618, PubMed:21593315). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:14722618). In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:21593315). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (PubMed:24616101). Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+) (PubMed:24616101). | ||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 2
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| Sequence (Fasta) | MAWLRLQPLT SAFLHFGLVT FVLFLNCLRA EAGDSGDVPS AGQNNESCSG SSDCKEGVIL 60 PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 120 TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 180 IIGICVYVIP DGETRKIKHL RVFFVTAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 240 FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 300 FTPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 360 MMTGAGNILK KHAAEQAKKT SSMSEVHTDE PEDFASKVFF DPCSYQCLEN CGAVLLTVVR 420 KGGDISKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 480 FVRLSNVRVE EEQLAEGMLP AILNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 540 VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDAYGELEFK NDETVKTIHI 600 KVIDDKAYEK NKNYVIEMMG PRMVDMSVQK ALLLSPEVTD RKLTVEEEEA KRIAEMGKPV 660 LGEHPKLEVI IEESYEFKST VDKLIKKTNL ALVVGTHSWR DQFMEAITVS AGGDEDEDES 720 GEERLPSCFD YVMHFLTVFW KVLFACVPPT EYCHGWACFV VSILIIGMLT AIIGDLASHF 780 GCTIGLKDSV TAVVFVAFGT SVPDTFASKA AALQDVYADA SIGNVTGSNA VNVFLGIGLA 840 WSVAAIYWAM QGQEFHVSAG TLAFSVTLFT IFAFVCLSVL LYRRRPHLGG ELGGPRGCKL 900 ATTWLFVSLW LLYILFATLE AYCYIKGF 929 |
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| Keyword | KW-0002--3D-structure |
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| Interpro | IPR003644--Calx_beta |
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| PROSITE | |||||||||||||
| Pfam | |||||||||||||
| Gene Ontology | GO:0043197--C:dendritic spine |