| Tag |
Content |
| dbPAF ID |
dbPAF-0054021 |
| Uniprot Accession |
S4R1M9; OSB10_MOUSE; Q8R2T7;
|
| Genbank Protein ID |
NP_683761.1; XP_006512433.1;
|
| Genbank Nucleotide ID |
NM_148958.2; XM_006512370.1;
|
| Protein Name |
Oxysterol-binding protein-related protein 10 |
| Protein Synonyms/Alias |
|
| Gene Name |
Osbpl10 |
| Gene Synonyms/Alias |
Orp10; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.Functional Description
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine. |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MERAAQSTDG GGGGGSNSSS RSSSRATSAG SSPSCSLAGR GVASRSGAAG LGGGGSRSSP 60
GSVAASPSGG GGRRREPALE GVLSKYTNLL QGWQSRYFVL DFEAGLLQYF VNEQSKHQKP 120
RGVLSLSGAI VSLSDEAPHM LVVYSANGEM YKLRAADSKE KQLWVTQLRA CAKYHMEMSS 180
KTTPGSRSRS LTLLPHGTPS SASPCSQRHL STGAPGVVSV TRHKSPAAAR RAKSQYSGQL 240
HEVREMMNQV EGQQKNLVHA IESLPGSGPL TALDQDLLLL KATSAATLSC LGECLSLLQQ 300
SVRQAAPPSH KPGASETILG WHGPTSHSTD QLKNGTLGSL PSASANITWA ILPNSAEEEH 360
NSQPEPEPDS GPELVLSEEE QSDNEDKGEV EPGAMEDQRS VILHLISQLK LGMDLTKVVL 420
PTFILEKRSL LEMYADFMAH PDLLLAITAG ATPEERVISF VEYYLTAFHE GRKGTLAKKP 480
YNPIIGETFH CSWEVPKDRV KSKWTSPHPP ISAHEHPMAD DPSKSYKLRF VAEQVSHHPP 540
ISCFYCECKE KRLCVNTHVW TKSKFMGMSV GVSMIGEGVL RLLDHGEEYV FTLPSAYARS 600
ILTVPWVELG GKVNISCAKT GYSATVTFHT KPFYGGKVHR VTAEVKHNPT NTIVCKAHGE 660
WNGTLEFTYS NGETKVIDTT TLPVYPKKLR PLEKQGPMES RNLWQEVTHY LRLGDIDAAT 720
EQKRRLEERQ RVEERKRETL RTPWRPKYFI PEGDGWVYFN PLWKTH
767Fasta Sequence
>S4R1M9|Osbpl10|Mus musculus(Mouse)
MERAAQSTDGGGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVASRSGAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQSRYFVLDFEAGLLQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMYKLRAADSKEKQLWVTQLRACAKYHMEMSSKTTPGSRSRSLTLLPHGTPSSASPCSQRHLSTGAPGVVSVTRHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLSLLQQSVRQAAPPSHKPGASETILGWHGPTSHSTDQLKNGTLGSLPSASANITWAILPNSAEEEHNSQPEPEPDSGPELVLSEEEQSDNEDKGEVEPGAMEDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVISFVEYYLTAFHEGRKGTLAKKPYNPIIGETFHCSWEVPKDRVKSKWTSPHPPISAHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLDHGEEYVFTLPSAYARSILTVPWVELGGKVNISCAKTGYSATVTFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYSNGETKVIDTTTLPVYPKKLRPLEKQGPMESRNLWQEVTHYLRLGDIDAATEQKRRLEERQRVEERKRETLRTPWRPKYFIPEGDGWVYFNPLWKTH
|
| Keyword |
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0445--Lipid transport
KW-0446--Lipid-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0813--Transport
|
| Interpro |
IPR000648--Oxysterol-bd
IPR018494--Oxysterol-bd_CS
IPR011993--PH/PTB_dom
IPR001849--PH_domain
|
| PROSITE |
PS01013--OSBP
PS50003--PH_DOMAIN
|
| Pfam |
PF01237--Oxysterol_BP
PF00169--PH
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0015485--F:cholesterol binding
GO:0001786--F:phosphatidylserine binding
GO:0006629--P:lipid metabolic process
GO:0006869--P:lipid transport
|
