dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0053991
Uniprot Accession M9PHU0; M9PHU0_DROME;
Genbank Protein ID NP_001259643.1;
Genbank Nucleotide ID NM_001272714.2;
Protein Name CG43658, isoform C
Protein Synonyms/Alias
Gene Name CG43658
Gene Synonyms/Alias Dmel_CG43658;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
1941FTAKIRASLANSPAFPhosphoPep 2.019060867
1945IRASLANSPAFHRKRPhosphoPep 2.0;SysPTM 2.019060867; 18327897; 19366988
2038MYEGMRRSDPELAAIPHOSIDA;PhosphoPep 2.0;SysPTM 2.021081558; 19060867; 18327897; 19366988
2065MKASRPRSLDLSNWSSysPTM 2.018327897; 19366988
Sequence
(Fasta)
MESLGLGSRR NNGSNSTAAP TTGQGGVVGG GGVAGKVLVH TKLKQQQQQQ HSNQNYYTQQ 60
QTQLQRLKQQ QQKLQQQQQQ QQQQQLEAVH GGVAKQCLQF PPPPDYPPPI TGGGGSPVNT 120
TPGRRQQLPR YPDPDPDAIE ICNESATLET SPYHLKQLAA RHSKTLGRNL GHQPHHHHTV 180
HLHHDYSYAY YEPGAAMRHS NVPGAVSSGG GGGGGGAGRV SSVVDTSSSS SPTAEPPPNS 240
IRALLSKGKK NKQLVSPATL QSYQTRYHKL TTKSGMGQSE NFYEEINAAA LQTSSGHHLR 300
STVGSHSAGS LNQTLVEEEL RRVQNRHHKI LGELNLSVEA MLMPESPPKS IDQQPLGSGS 360
GGSGGAEATP PQPSVSVTAA SGQPPTILAR LTSASADNIC DSGGEAGKRT KTAPGCPGGG 420
VEQLLTTTCG DLDSGFSGSS GASYIGSLRL SKTQHIKCAR QTPTVGTQSC RSFQRAATVY 480
DEAGMSGGGG QSGSSFLTRA SCGRRILSCA RIRAAEDPGP NHRIAGGNGI QTVQTTATES 540
KARSFWSRKG WRKLPGFSTS TSSINDTGLS DEHKLNSGSW EDTLDEPHHH HAHHSHHQQH 600
LHQHHSHLSQ RHQQQQQQQQ QLQQTSFIGS PPSSASITTA QLHSAFSRRI AEQRERDQRD 660
QRDQREAVGC TAATIAGGSF SANGGQAAVG VGVGSSSSCG SSSERDTKSP CRERDRNLER 720
DRDRERDKND DLGEEEVLTE EEQTSSSVSS LSAGNQRNSQ LRSTFNKAKQ HLSFDKWRTA 780
ATGSATGSAS GPGSSATDSN NAASNMIMRR ASACTMPSSG GGGGAGVGSS QREEATTPGE 840
SPGGRLSRWF SIRRGSSHQY DVGGRDGRHS TASSFDTPDS GSGNSPKNGS NAVAGTGGAG 900
SQGVALDAAS PQKLANLGAS KMMPGVPESE DDEATANRFD VDLMMTPGSR ANGTARTAHN 960
RLIVPMLPPA PAGLSQQQLK RRHIVAAIVH SENSYVATLQ RLVNDYKKPL EECSPPVLNP 1020
VKIATLFHCL PDILHSHKLF RISLAECVRN WDRDEKIGDC FVSAFGKPQL LEIYSGFINN 1080
FSAAMELAKM EEKRKSALAD FFKVKQISAH DRLSFFGLMV KPVQRFPQFI LFLQDLLKYT 1140
PQGHHDRMSL QLALSQLELL AELLNESKRE AEQYQAFKEM LGHISGTFNA RSLSLSSVSV 1200
SDSAGGHRPR YLLREDNVTH MEFNQAGFIV KCKQRRLLLL NDKVICVSVA PKQSHDFGAT 1260
EKLTFKWMFP VNDVEIVDNS TSATLSRILT AGLNRGGSLK SNGSSGANGS PYANSTLPGH 1320
GGGVSGFSGF GDPHSSPAAQ LTNGADNLCS EMSTLMYDYE VISRIQDLVS SLKGSYKELN 1380
ANTTRNVLNL IQGSIQRKDE EMAWVDSCCL QLIGRHKSGK EETFTFQTQT PAVKKEWITE 1440
LRLAQLALDP NNSPAWERGG SHPQPAHHHP HHHPLQHPHA GAGDPRQTQE QLQLQEAVQQ 1500
KQSRKMPLFV KAMPVYKSQH QTEVRCGCYY SIANDTKQSG NARRRHKQLN YLWMCSSDGT 1560
SSHITVLAQH PQQAGNLREA GAFDLFETQV SALEFVKGLD QLKSRDEPAS LLGDLVWLGT 1620
DSRKILIYSA RNPEQEEQLG SYSVPGAVQR ILYHFDAVYV ALSGATVLIF RRGNDGVWQL 1680
RDPQTIRLGD TDLVVPSLLP INMCIYASCG NRVYVMNALN GEIQRSFEVQ HGATQQVNLM 1740
AHSGIGLWIS LKNSTMLCLY HTETFKHLQD INIASSVLRH DGKKEQPLNN SSVYVTALMA 1800
CKGLLWVGTN VGIAVTIPLP RLEGVPIISG GINMSCHAHF GPITFLLPLI PKVYPAYKPP 1860
TVGAAPLVPS MGDDLQLPAI DADPKIQELD DGAVVLRRDL AKEEMSSSNP GADSTASSPR 1920
SSKLDKQNSL DQSFTAKIRA SLANSPAFHR KRFRDDPNRM SKTLPRGLGA AAAGSGAGGA 1980
SAAGSGTASG NTSQHGEHGI CDVYGLYGKL IFVKEDYDAE EGNQGNLMDM MYEGMRRSDP 2040
ELAAIPGKVC TLDRRLRMKA SRPRSLDLSN WSVDSKSSSL YTSSGSEESM GIRHFGGRSV 2100
SRNSSSASHK TSGTGSDLGN ISENGLMTTA DIHHHQQQQQ QLNSSAKPDE MSRLGAGNSG 2160
LDKPAAAVAT LKRKQKQNSK QQQQQNADGP RTVITLMGGR GYWRQMWYNG AGGSPSHKNS 2220
SSGGGGGSGS GFSGQTMQSG NPSCSPLTAN SNDAHIVVWE KKL 2264
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001849--PH_domain
IPR011047--Quinoprotein_ADH-like_supfam

PROSITE

PS50010--DH_2

Pfam

PF00621--RhoGEF

Gene Ontology

GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0007480--P:imaginal disc-derived leg morphogenesis
GO:0043547--P:positive regulation of GTPase activity
GO:0035025--P:positive regulation of Rho protein signal transduction