| Tag |
Content |
| dbPAF ID |
dbPAF-0053882 |
| Uniprot Accession |
M1ZMI3; M1ZMI3_CAEEL;
|
| Genbank Protein ID |
NP_001294725.1;
|
| Genbank Nucleotide ID |
NM_001307796.1;
|
| Protein Name |
NADPH-dependent diflavin oxidoreductase 1 |
| Protein Synonyms/Alias |
NADPH-dependent FMN and FAD-containing oxidoreductase; |
| Gene Name |
fre-1 |
| Gene Synonyms/Alias |
CELE_Y113G7A.8;Y113G7A.8; |
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View all) |
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog.Functional Description
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 193 | SGNDDDDSDEDLEPQ | Phospho.ELM 9.0;PHOSIDA;curated | 19530675; 21081558; 18806794 |
|
Sequence
(Fasta) | MSIAILYGSE TGTAQDIAES LRREAQQRHL QARVHELDEY DVSQLPMEKV VLFVVSTTGQ 60
GEMPPNMRKT WKLLLRKSLG ADFLKNVNIG VLGLGDSSYQ KYNFAGKKLY RRLVQLGAKM 120
MCGVHLADDQ HEIGIDGAFI PWKTECWKKI KEIAENLSIY REMTAEIDTS VQITTKYRFL 180
ELGGESGNDD DDSDEDLEPQ IEIPDYFPLK VLKNRRLTSA EHFQDTRLVD FEISDRNRSK 240
MGFQPGDVLM VRPYNPEETV KIAIEALGLT EEQLKKPLKI VKNDRFSKNP PNFLVGNFSA 300
KTTLLTCLQR YFDLQQVPKR SFFEMLGYYS TNPPEKERLQ ELASPEGLDD YLDYANRSRR 360
TTAEALRDFV ATSKNLKPDY LFEILTTIRP RAFSIASAPS PFHLELLVAK VEYKSRMADK 420
RRGLCSTFIS RLKPGDEVFC KIRPGTFKFP SPEAPVICIG PGTGVAPFRS LFGHRSLFSA 480
HFPGILFFGC RSEHHDYYFS DEWPELSGVA VIPAFSRDTD GRKVYVQHKM GENAGKIKRM 540
LDLGAQVFIA GSSGDMPKAV SAVLAQIQGD EWTRRAEETG KIQYETWS
589Fasta Sequence
>M1ZMI3|fre-1|Caenorhabditis elegans
MSIAILYGSETGTAQDIAESLRREAQQRHLQARVHELDEYDVSQLPMEKVVLFVVSTTGQGEMPPNMRKTWKLLLRKSLGADFLKNVNIGVLGLGDSSYQKYNFAGKKLYRRLVQLGAKMMCGVHLADDQHEIGIDGAFIPWKTECWKKIKEIAENLSIYREMTAEIDTSVQITTKYRFLELGGESGNDDDDSDEDLEPQIEIPDYFPLKVLKNRRLTSAEHFQDTRLVDFEISDRNRSKMGFQPGDVLMVRPYNPEETVKIAIEALGLTEEQLKKPLKIVKNDRFSKNPPNFLVGNFSAKTTLLTCLQRYFDLQQVPKRSFFEMLGYYSTNPPEKERLQELASPEGLDDYLDYANRSRRTTAEALRDFVATSKNLKPDYLFEILTTIRPRAFSIASAPSPFHLELLVAKVEYKSRMADKRRGLCSTFISRLKPGDEVFCKIRPGTFKFPSPEAPVICIGPGTGVAPFRSLFGHRSLFSAHFPGILFFGCRSEHHDYYFSDEWPELSGVAVIPAFSRDTDGRKVYVQHKMGENAGKIKRMLDLGAQVFIAGSSGDMPKAVSAVLAQIQGDEWTRRAEETGKIQYETWS
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0274--FAD
KW-0285--Flavoprotein
KW-0288--FMN
KW-0521--NADP
KW-0560--Oxidoreductase
KW-1267--Proteomics identification
KW-1185--Reference proteome
|
| Interpro |
IPR003097--FAD-binding_1
IPR017927--Fd_Rdtase_FAD-bd
IPR001094--Flavdoxin
IPR008254--Flavodoxin/NO_synth
IPR001709--Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039--Flavoprotein-like
IPR023173--NADPH_Cyt_P450_Rdtase_dom3
IPR028879--NDOR1
IPR001433--OxRdtase_FAD/NAD-bd
IPR017938--Riboflavin_synthase-like_b-brl
|
| PROSITE |
PS51384--FAD_FR
PS50902--FLAVODOXIN_LIKE
|
| Pfam |
PF00667--FAD_binding_1
PF00258--Flavodoxin_1
PF00175--NAD_binding_1
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0050660--F:flavin adenine dinucleotide binding
GO:0010181--F:FMN binding
GO:0005506--F:iron ion binding
GO:0050661--F:NADP binding
GO:0003958--F:NADPH-hemoprotein reductase activity
GO:0016226--P:iron-sulfur cluster assembly
|
