dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0053770
Uniprot Accession M0R7Z9; PLIN5_RAT;
Genbank Protein ID NP_001128109.1;
Genbank Nucleotide ID NM_001134637.1;
Protein Name Perilipin-5
Protein Synonyms/Alias Lipid storage droplet protein 5;
Gene Name Plin5
Gene Synonyms/Alias Lsdp5;Oxpat;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
155AQRGRRWSGELRRSVPhosphoSitePlus22135298
230GYFVRLGSLSARLRHPhosphoSitePlus22135298
Sequence
(Fasta)
MDQRGKDTTL ALHSRMSGDQ TAQDPGSSLG ELDQHNVVKR VVALPLVRAT CTAVSGAYNS 60
AKDRHPLLGS ACRFAEHCVC SVATCALDHA QPLLEHLQPK LATVNDLACR GLDKLEEKLP 120
FLQQPSDTVV TSAKDAVAKS VTGVVDLAQR GRRWSGELRR SVSQAMDTVL RRSVSQAMDT 180
VLGKSEELVD HFLPMTEAEL VALATESQGP EVGSVEEQRQ KQGYFVRLGS LSARLRHLAY 240
QHSLGKLRES KHRTQEMLAQ LQKTLELIQH MQSRASPTPT FHHPKVQELC GDWSPCLENG 300
YRHSQVELET LALSRSLTLE LQSAVDALAG CVRGLPPSAQ AKVAEVQRSV DALQATFADA 360
HCLGDVAPTA LAEGQDSVAQ AHACVDEFLD LVLRAMPLAW LVGPFAPILV ERSEPLINLA 420
TCVDEVVGDP DPRWAHMDWP AQQRAWEAEP ADPGGQEAEP PLGQVKHTMM PELDF 476
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0551--Lipid droplet
KW-0496--Mitochondrion
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR004279--Perilipin

PROSITE
Pfam

PF03036--Perilipin

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005739--C:mitochondrion
GO:0035473--F:lipase binding
GO:0034389--P:lipid particle organization
GO:0019915--P:lipid storage
GO:0051646--P:mitochondrion localization
GO:0031999--P:negative regulation of fatty acid beta-oxidation
GO:0060192--P:negative regulation of lipase activity
GO:0035359--P:negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0010897--P:negative regulation of triglyceride catabolic process
GO:0032000--P:positive regulation of fatty acid beta-oxidation
GO:0060193--P:positive regulation of lipase activity
GO:0010884--P:positive regulation of lipid storage
GO:0010890--P:positive regulation of sequestering of triglyceride
GO:0010867--P:positive regulation of triglyceride biosynthetic process