| Tag |
Content |
| dbPAF ID |
dbPAF-0053722 |
| Uniprot Accession |
M0R629; M0R629_RAT;
|
| Genbank Protein ID |
XP_001072867.1; XP_003750285.1;
|
| Genbank Nucleotide ID |
XM_001072867.5; XM_003750237.3;
|
| Protein Name |
Adenylosuccinate synthetase isozyme 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
Adssl1 |
| Gene Synonyms/Alias |
Adss1;rCG_27771; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.Functional Description
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MSGTRASNDR PPGTGGVKRG RLQQEAAATG SRVTVVLGAQ WGDEGKGKVV DLLATDADIV 60
SRCQGGNNAG HTVVVDGKEY DFHLLPSGII NTKAVSFIGN GVVIHLPGLF EEAEKNEKKG 120
LKDWEKRLII SDRAHLVFDF HQAVDGLQEV QRQAQEGKNI GTTKKGIGPT YSSKAARTGL 180
RICDLLSDFD EFSARFKNLA HQHQSMFPTL EIDVEGQLKR LKGFAERIRP MVRDGVYFMY 240
EALHGPPKKI LVEGANAALL DIDFGTYPFV TSSNCTVGGV CTGLGIPPQN IGDVYGVVKA 300
YTTRVGIGAF PTEQINEIGD LLQNRGHEWG VTTGRKRRCG WLDLMILRYA HMVNGFTALA 360
LTKLDILDVL SEIKVGISYK LNGKRIPYFP ANQEILQKVE VEYETLPGWK ADTTGARKWE 420
DLPPQAQSYV RFVENHLGVA VKWVGVGKSR ESMIQLF
458Fasta Sequence
>M0R629|Adssl1|Rattus norvegicus(Rat)
MSGTRASNDRPPGTGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHLGVAVKWVGVGKSRESMIQLF
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0342--GTP-binding
KW-0436--Ligase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-0658--Purine biosynthesis
KW-1185--Reference proteome
|
| Interpro |
IPR018220--Adenylosuccinate_synthase_AS
IPR001114--Adenylosuccinate_synthetase
IPR027509--AdSS_1_vert
IPR027417--P-loop_NTPase
|
| PROSITE |
PS01266--ADENYLOSUCCIN_SYN_1
PS00513--ADENYLOSUCCIN_SYN_2
|
| Pfam |
PF00709--Adenylsucc_synt
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0051015--F:actin filament binding
GO:0004019--F:adenylosuccinate synthase activity
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0000287--F:magnesium ion binding
GO:0042803--F:protein homodimerization activity
GO:0044208--P:'de novo' AMP biosynthetic process
GO:0006531--P:aspartate metabolic process
GO:0035690--P:cellular response to drug
GO:0071257--P:cellular response to electrical stimulus
GO:0006541--P:glutamine metabolic process
GO:0046040--P:IMP metabolic process
GO:0009168--P:purine ribonucleoside monophosphate biosynthetic process
GO:0014850--P:response to muscle activity
GO:0042594--P:response to starvation
|
