| Tag |
Content |
| dbPAF ID |
dbPAF-0053655 |
| Uniprot Accession |
M0R0Q7; M0R0Q7_HUMAN;
|
| Genbank Protein ID |
|
| Genbank Nucleotide ID |
|
| Protein Name |
DNA ligase |
| Protein Synonyms/Alias |
|
| Gene Name |
LIG1 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 162 | EEETPKESLTEAEVA | curated | 25849741 |
|
Sequence
(Fasta) | MQRSIMSFFH PKKEGKAKKP EKEASNSSRE TEPPPKAALK EWNGVVSESD SPVKRPGRKA 60
ARVLGSEGEE EDEALSPAKG QKPALDCSQV SPPRPATSPE NNASLSDTSP MDSSPSGIPK 120
RRTARKQLPK RTIQEVLEEQ SEDEDREAKR KKEEEEETPK ESLTEAEVAT EKEGEDGDQP 180
TTPPKPLKTS KAETPTESVS EPEVATKQEL QEEEEQTKPP RRAPKTLSSF FTPRKPAVKK 240
EVKEEEPGAP GKEGAAEGPL DPSGYNPAKN NYHPVEDACW KPGQKVPYLA VARTFEKIEE 300
VSARLRMVET LSNLLRSVVA LSPPDLLPVL YLSLNHLGPP QQGLELGVGD GVLLKAVAQA 360
TGRQLESVRA EAAEKGDVGL VAENSRSTQR LMLPPPPLTA SGVFSKFRDI ARLTGSASTA 420
KKIDIIKGLF VACRHSEARF IARSLSGRLR LGLAEQSVLA ALSQAVSLTP PGQEFPPAMV 480
DAGKGKTAEA RKTWLEEQGM ILKQTFCEVP DLDRIIPVLL EHGLERLPEH CKLSPGIPLK 540
PMLAHPTRGI SEVLKRFEEA AFTCEYKYDG QRAQIHALEG GEVKIFSRNQ EDNTGKYPDI 600
ISRIPKIKLP SVTSFILDTE AVAWDREKKQ IQPFQVLTTR KRKEVDASEI QVQVCLYAFD 660
LIYLNGESLV REPLSRRRQL LRENFVETEG EFVFATSLDT KDIEQIAEFL EQSVKDSCEG 720
LMVKTLDVDA TYEIAKRSHN WLKLKKDYLD GVGDTLDLVV IGAYLGRGKR AGRYGGFLLA 780
SYDEDSEELQ AICKVLGNWG
801Fasta Sequence
>M0R0Q7|LIG1|Homo sapiens(Human)
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKVLGNWG
|
| Keyword |
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0235--DNA replication
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
|
| Interpro |
IPR000977--DNA_ligase_ATP-dep
IPR012310--DNA_ligase_ATP-dep_cent
IPR016059--DNA_ligase_ATP-dep_CS
IPR012308--DNA_ligase_ATP-dep_N
IPR012340--NA-bd_OB-fold
|
| PROSITE |
PS00697--DNA_LIGASE_A1
PS00333--DNA_LIGASE_A2
PS50160--DNA_LIGASE_A3
|
| Pfam |
PF01068--DNA_ligase_A_M
PF04675--DNA_ligase_A_N
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003910--F:DNA ligase (ATP) activity
GO:0071897--P:DNA biosynthetic process
GO:0006266--P:DNA ligation
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0006273--P:lagging strand elongation
GO:1903461--P:Okazaki fragment processing involved in mitotic DNA replication
GO:1903469--P:removal of RNA primer involved in mitotic DNA replication
|
