dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0053647
Uniprot Accession M0QZR4; M0QZR4_HUMAN;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Rho guanine nucleotide exchange factor 1
Protein Synonyms/Alias
Gene Name ARHGEF1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
384GRLGRSESLRVSDRRcurated25003641
408KGRGGGRSRSDVDMDcurated25627689; 25003641
410RGGGRSRSDVDMDPScurated25850435; 25627689
430LGPARRATPEPGDEGcurated25850435; 25627689
Sequence
(Fasta)
MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE QVKRRPAHLM 60
ALLQHVALQF EPGPLLCCLH ADMLGSLGPK EAKKAFLDFY HSFLEKTAVL RVPVPPNVAF 120
ELDRTRADLI SEDVQRRFVQ EVVQSQQVAV GRQLEDFRSK RLMGMTPWEQ ELAQLEAWVG 180
RDRASYEARE RHVAERLLMH LEEMQHTIST DEEKSAAVVN AIGLYMRHLG VRTKSGDKKS 240
GRNFFRKKVM GNRRSDEPAK TKKGLSSILD AARWNRGEPQ VPDFRHLKAE VDAEKPGATD 300
RKGGVGMPSR DRNIGAPGQD TPGVSLHPLS LDSPDREPGA DAPLELGDSS PQGPMSLESL 360
APPESTDEGA ETERLSGRLG RSESLRVSDR RRPSRGSLGA KGRGGGRSRS DVDMDPSSAT 420
AVLGPARRAT PEPGDEGEPG RSGLELEPEE PPGWRELVPP DTLHSLPKSQ VKRQEVISEL 480
LVTEAAHVRM LRVLHDLFFQ PMAECLFFPL EELQNIFPSL DELIEVHSLF LDRLMKRRQE 540
SGYLIEEIGD VLLARFDGAE GSWFQKISSR FCSRQSFALE QLKAKQRKDP RFCAFVQEAE 600
SRPRCRRLQL KDMIPTEMQR LTKYPLLLQS IGQNTEEPTE REKVELAAEC CREILHHVNQ 660
AVRDMEDLLR LKDYQRRLDL SHLRQSSDPM LSEFKNLDIT KKKLVHEGPL TWRVTKDKAV 720
EVHVLLLDDL LLLLQRQDER LLLKSHSRTL TPTPDGKTML RPVLRLTSAM TREVATDHKA 780
FYVLFTWDQE AQIYELVAQT VSERKNWCAL ITETAGSLKV PAPASRPKPR PSPSSTREPL 840
LSSSENGNGG RETSPADART ERILSDLLPF CRPGPEGQLA ATALRKVLSL KQLLFPAEED 900
NGAGPPRDGD GVPGGGPLSP ARTQEIQENL LSLEETMKQL EELEEEFCRL RPLLSQLGGN 960
SVPQPGCT 969
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR016137--RGS
IPR015212--RGS-like_dom

PROSITE

PS50010--DH_2
PS50003--PH_DOMAIN

Pfam

PF16652--PH_13
PF09128--RGS-like
PF00621--RhoGEF

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035023--P:regulation of Rho protein signal transduction