dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0053587 |
| Uniprot Accession | L0N7N1; KIF14_MOUSE; |
| Genbank Protein ID | NP_001274108.1; XP_006529792.1; |
| Genbank Nucleotide ID | NM_001287179.2; XM_006529729.2; |
| Protein Name | Kinesin-like protein KIF14 |
| Protein Synonyms/Alias | |
| Gene Name | Kif14 |
| Gene Synonyms/Alias | |
| Organism | Mus musculus(Mouse) |
| NCBI Taxa ID | 10090 |
| Functional Description (View all) |
Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (PubMed:24949858). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (By similarity). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (By similarity). Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (By similarity). During late neurogenesis, regulates the cerebellar and cerebral cortex development and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (PubMed:23308235, PubMed:24931760). Also is required for chromosome congression and alignment during mitotic cell cycle process (By similarity). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 7 |
| Sequence (Fasta) | MSVHTSHSRH NIGSLEVSSS QKISASSGLV HSSRLELHLK ADMSECENHD PFVNAGSKTI 60 DINSTYVISA CKKTRETPVT SDPRRLSLQR RATCGDRESS LLGSELGNRR TADTSLRLQR 120 RHGRADYVGK WETLNPVGGN PGSDSASQAS RTEAKGVNND TRVLSSVVSV KDSNDTGLTR 180 CKDPGPPVGA SNEKVTVKDT NSRAPVGSQR QTEAMRSGHL VVQLTESKSD TPVSGGRNSH 240 RGNAGKDTAK QVGTFGSSDT RTPVKCVLEH RWTPRHDPPP PKSPALSTPK NNGKDIPKHG 300 STFRSASSES RTPVKCVPEH RWTPRHDLPP PKSPALSTLK NRIASPRVKP RPKSSLFANK 360 RESSRESTLP PEENSLVQKT FTEPDSLKVE NSQVTVAVRV RPFSKREKTE KASQVVFTNG 420 EEITVEHPDM KQVYSFIYDV SFWSFDECHP GYASQTTVYE TLAAPLLDRA FEGYNTCLFA 480 YGQTGSGKSY TMMGLNEEPG IIPRFCEDLF AQIAKKQTSE VSYHLEMSFF EVYNEKIHDL 540 LVCKGENGQR KQPLRAREHP VSGPYVEGLS MNVVSSYSDI QSWLELGNKQ RATAATGMND 600 KSSRSHSVFT LVMTQTKTEV VEGEEHDHRI TSRINLVDLA GSERCSTAHS SGQRLKEGVS 660 INKSLLTLGK VISALSEQAN GKRVFIPYRE STLTWLLKES LGGNSKTAMI ATVSPAASNI 720 EETLSTLRYA TQARLIVNIA KVNEDMNAKL IRELKAEIEK LKAAQRSNRN IDPERYRLCR 780 QEITSLRMKL HQQERDMAEI QRVWKEKFEQ AEKRKLQETK ELQKAGVTFQ MDNHLPNLVN 840 LNEDPQLSEM LLYMVKEGVT TVGKHTPSSS HDIQLSGVLI ADDHCTIRNF GGTVSIVPAG 900 EAKTYVNGTH ISEPTVLHHG DRVVLGGDHY FRFNHPVEVQ KGKKLSSRNN LTTSEGPKDF 960 EFAKNELLTA QRSRLEAEIK DAQLKAKEEM MQGIQIAKEM AQQELSSQKA VYERKIQALE 1020 AELREESQRK RLEELNNQKA SHKIEELERA KQHLEQEVYV NKRRLEMETL ATKQALEDHR 1080 IRHARILEAL EIEKQKIAEE VQMLQENRGN RDKTFTIQPN WNSMKLSTMI QEANAISDKF 1140 KKCYIFGRHD ASDKGRSDTS VRVRNLQLGI STFWSLEKFE SKLAAMKELY ESNGGDRDED 1200 VFCDPADEWE PDITSTPVSS LSRRRSRSLM KNRRVSGCLH DIHPIQSMQS SHSSGLMEKP 1260 STIYSNSSES FLPGICKELI GSSIDFLGQS FDEEKTIADS LINNLLRLHN GVIAISKAHE 1320 EQDEESQDNL FSDRAAQALT IQVACAFEQL VVLFKHWLGD FLPCTGSARL EDELRQDIKK 1380 LGGYLQLFLQ GCCSDISSMV KEAQNKVMKI IQQAVQCVGQ LAVLKGSKLC VLENSSKVSS 1440 TQEFMAALQD GVTSGMKSLL DSGLETAQDL RQDLSRQSAR EEVTKQMKAS TVEWVGSLEN 1500 AVAEWRTKSF RTQAQEGSRQ QVSKLLSLAS EFLKLKSCLQ QTVEMIVSAL RGCPSDLHCL 1560 RSCTETICSL ARKLHSDFSA HSASAGSCGN ELPRADCEEL ESLAKSLLLC FECGESPGLS 1620 KPWESCSSNS KEEQCKSDRA DCGKSGPRRA CEPHGDATPA VSSGDCTPNR IQWV 1675 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR000253--FHA_dom |
| PROSITE | PS50006--FHA_DOMAIN |
| Pfam | |
| Gene Ontology | GO:0005737--C:cytoplasm |