dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0053478
Uniprot Accession J3QSD7; J3QSD7_HUMAN;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Cyclin-dependent kinase 12
Protein Synonyms/Alias
Gene Name CDK12
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
334YGRRRSSSPFLSKRScurated25627689
338RSSSPFLSKRSLSRSPhosphoSitePlus;curated22135298; 25627689
341SPFLSKRSLSRSPLPPhosphoSitePlus;curated22135298; 25627689; 23898821
343FLSKRSLSRSPLPRKPhosphoSitePlus;curated22135298; 25627689; 23898821
345SKRSLSRSPLPRKSMPhosphoSitePlus;curated22135298; 25627689; 23898821; 23663014
Sequence
(Fasta)
MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 60
ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR 120
DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH 180
KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA 240
SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR 300
SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPRK SMKSRSRSPA 360
YSRHSSSHSK KKRSSSRSRH SSISPVRLPL NSSLGAELSR KKKERAAAAA AAKMDGKESK 420
GSPVFLPRKE NSSVEAKDSG LESKKLPRSV KLEKSAPDTE LVNVTHLNTE VKNSSDTGKV 480
KLDENSEKHL VKDLKAQGTR DSKPIALKEE IVTPKETETS EKETPPPLPT IASPPPPLPT 540
TTPPPQTPPL PPLPPIPALP QQPPLPPSQP AFSQVPASST STLPPSTHSK TSAVSSQANS 600
QPPVQVSVKT QVSVTAAIPH LKTSTLPPLP LPPLLPGDDD MDSPKETLPS KPVKKEKEQR 660
TRHLLTDLPL PPELPGGDLS PPDSPEPKAI TPPQQPYKKR PKICCPRYGE RRQTESDWGK 720
RCVDKFDIIG IIGEGTYGQV YKAKDKDTGE LVALKKVRLD NEKEGFPITA IREIKILRQL 780
IHRSVVNMKE IVTDKQDALD FKKDKGAFYL VFEYMDHDLM GLLESGLVHF SEDHIKSFMK 840
QLMEGLEYCH KKNFLHRDIK CSNILLNNSG QIKLADFGLA RLYNSEESRP YTNKVITLWY 900
RPPELLLGEE RYTPAIDVWS CGCILGELFT KKPIFQANLE LAQLELISRL CGSPCPAVWP 960
DVIKLPYFNT MKPKKQYRRR LREEFSFIPS AALDLLDHML TLDPSKRCTA EQTLQSDFLK 1020
DVELSKMAPP DLPHWQDCHE LWSKKRRRQR QSGVVVEEPP PSKTSRKETT SGTSTEPVKN 1080
SSPAPPQPAP GKVESGAGDA IGLADITQQL NQSELAVLLN LLQSQTDLSI PQMAQLLNIH 1140
SNPEMQQQLE ALNQSISALT EATSQQQDSE TMAPEESLKE APSAPVILPS AEQTTLEASS 1200
T 1202
Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

Gene Ontology

GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity