dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0053386
Uniprot Accession J3KPF0; J3KPF0_HUMAN;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Probable E3 ubiquitin-protein ligase HECTD4
Protein Synonyms/Alias
Gene Name HECTD4
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
241SLKTFVHTVHLLQKQPhosphoSitePlus22135298
Sequence
(Fasta)
MGSSAAAAAA AAAAADSAQW LSVKEETIFL HDGLIRVTDL AELPSEILGA PEAADTDLEI 60
LTFETKNPSE LAERLRSVCG NQSNAYARLL EYRLNALRGL WNAQRQLALE EQHERESSGD 120
EETLALLKRQ GLLQQPEQAP FTSRMGLLLV FPLIQSQSRT DPSLCNITAE VLLNCLRDCQ 180
PLSLTKEPAD CLNGIETLLC SWLEETSDTG RHIPHKQKEN AAAALVALAC ARGSLKTFVH 240
TVHLLQKQTD LGSLPVADVL YRLLLLEGGP GSPSCLLGGK HIVSWGYEDM LPAPDSNTGS 300
SSENKDADLG RCLTADGLYL YTTNSVGRGV SKLGSGLHGT LRGFVYCRNE ELEPGWVAFG 360
SGSLLHRPVS FDNKPHSLFQ VIDQNTLQVC QVVPMPANHL PIGSTMSTVH LSSDGTYFYW 420
IWSPASLNEK TPKGHSVFMD IFELVVENGV FVANPLQERT ILMRKEGESA KSINEMLLSR 480
LSRYRASPSA TLAALTGSTI SNTLKEDQAA NTSCGLPLKM LRKTPIYTCG TYLVMLVPPP 540
GGSGSSATRS LFGGTSGLSS LKILASSLVY NISDGQFTSR ADLIDAAGSS LGRGALVPGL 600
GACYDTVNNM LWTCSNDYID QWCNPGNQAF HYVCQRLGVS HIITEPKEEA ITTNEVINQL 660
LHHVGAMCIH QLNLLATNPN LPITSVLGKQ HPIEAHHLSS ICDIMEKAMV NGDTCIIRCI 720
LVVFQVVFKF FFSPQTERNR DIIRRSGLLL WQLLMAPKDQ ICPEIQKEVC LAISSGLNIL 780
YPGETEINNL LKLVLTEGER NSGLSQLRDV ILTNLAEQLQ NNRFGSDEDD HYRLNDELLH 840
YILKIVVRES CILITKCQTV SKDDFQKLLS TVPAASSCLR YLMAVQNHLL SNTILIKPDE 900
NDDSDSSLQG ETLKELKVSI LALATQILTG CDEVLEMLQQ VTTALINSDI ADREQRLKGL 960
EQVTKATMLG HLLPVLLTSL MHPNLQTLIM ADALMPQLVQ LVLYTSQTAL LLKTQCPVFA 1020
EVGCSPCGAP DQKCRLFPDE RMLEEKEEPG FLTGLKIPAP WAAGKTVETV HPVRDNYKFK 1080
ETVHIPGARC LYLRFDSRCS SQYDYDKLVI YAGPNTNSRK VAEYGGNTLG YGSRSVLGTG 1140
WPKDLVKVEG DTVTFSFEMR SGREHNTPDK AMWGFACTVR AQESSEDVSG GLPFLVDLAL 1200
GLSVLACSML RILYNGPEIT KEEEACQELL RSKLLQRCQW QVEANGVISP ALTPSPSPLP 1260
LTIEEDREFT YPSDVLVPPV GNYFDLPRIR LPPGIMIKLR EISGRARPQF RPSIKEVIQP 1320
DVMEEMVVSC VIKHLNLVDA LQSLINFQYQ EEHAEEYDLL CKIMGETFKK LNAMERQLQS 1380
VAELEQKWQS EVDDAMQGKL ENNMPFFYDY HFNENKMKEL ELLCSMKEVS FDGNDLENMV 1440
LSLREKFLQE VNSLIQKPSH PLAKTKTLVK SLMNRAELLL HVTIAAQSGL TRSISGTPAE 1500
TPACKSASET KVISHAVRQP VFLRSMSAPS DLEMIGNEDL EFTRANQRRR HVTSHRSSSF 1560
TLLQSLAIED SRDKPTYSVL LGQLFAFIGT NPDQAVSSSS FLLAAQTRWR RGNTRKQALV 1620
HMRELLTAAV RVGGVTHLVG PVTMVLQGGP RIEELTCGGM VEQVQEAFGE TMTSVVSLCA 1680
RYPIACANSI GLLCTIPYTR SEEKCLVRSG LVQLMDRLCS LSNQTESSSS EKQTKKQKVA 1740
TMAWAAFQVL ANRCVEWEKE EGGSTEAVHS GLARQVSSLL TNHLARATEC CGNQAAGNDA 1800
LQDVLSLLND LSRSHIGKAI LSQPACVSKL LSLLLDQRPS PKLVLIILQL CRAALPLMSV 1860
EDCGNVELPP WSYSVPSLNS EQEDPSDPAS KIASLLLAKL ADYVVPGCQT VLSPTASEPD 1920
TTLTKTSPKN SLKGDKDPGE ESEAVDGKLS IFIHKREDQS SHEVLQPLLS SSEGRPFRLG 1980
TGANMEKVVK MDRDMTKGGC CEVITEEAAA ALRKATKWAQ SGLIVSIGPP VESINPETVS 2040
GLSTGDKKKT AQTSICRERN SELARTDPVR PFISGHVANS MAAEVIALLH SLLMAPESNA 2100
AQIWTTTAEK VLSRALMYIP QLGKYAESIL ENGSSSGRKL AKLQRIARQA VAALCALGGF 2160
KETIKIGSEV QVLGRGISGS IGVVASINEQ EGIATVRFPP IDCRKTSQAS DTLTIPLSRL 2220
CVPRSEALPL HKLSITEKVV QAVQSMLLPQ EGSLSIHTSL PATGDGSAPV MAVVRLLAEI 2280
RTRACLVMAQ LLEDSLFCEE FIQQCPAAVE VLNLVAQECS AGERLAVVEV QCERLRMLYR 2340
DCARPPPPPL QADRRQPKEI TWSPSRVFPP VRACMFSSHL TSVTFLADPS AGGGLPRGTF 2400
IYATSPLPVQ APSFYWEIEI VSYGDTDDDT GPIVSFGFTT EAEKRDGAWT NPVGTCLFHN 2460
NGRAVHYNGS SLLQWKSVRL DVTLSPGDVA GIGWERTEGT PPPPGQPAKG RVYFTYCGQR 2520
LSPYLEDVSG GMWPVVHIQK KNTKTRANFG SRPFAYAEGQ AHRNAADLCT DLAEEISANF 2580
EALPFAMASD SDNDAGTSIA SDPGTHGPPC RIAAVATAQQ QYDSDTSCHY KVELSYENFI 2640
TSGPDPHPPP IADDESDDDD DDDIPQEDHY ALLVKAWETK VFPTIRRRFR NEAERKSGLD 2700
QIKGALQLGM VDIARQTVEF LYEENGGIPR DLYLPTIEDI KDEANKFTID KVRKGLTVVT 2760
RSPDSNNVAS SAVGTALPKF AIRGMLKTFG LHGVVLDVDS VNELVQVETY LRSEGVLVRY 2820
WYPIDMLERP PAGYRRTATN GLVTLDNTNL QIHRELLRCE AALARLYCRM ALLNIFAPKL 2880
PHLFTRLFHI PAIRDITLEH LQLLSNQLLA PPLPDGTISS SSILLAQSLQ HCIHSQNCSA 2940
TDLFYQGNSQ TVREWLNVAI TRTLHQGEES LLELTKQICS FLQTAPEQFP SEEFPISESK 3000
VNMDVNFPGA AFVVVSCKES QSGFRKDSSL YKAPWARVLV YGLGHKVKRN GQLNLIEAAC 3060
YPRDASPANT GLAPPPTADQ YPSVVLSTDR VHIKLGVSPP PGAVLVLHSL PLEFPLAMAF 3120
AEQLLSWKSE DSEGKSEDEP DTIPTSVLLQ VVELLGNFLW TTDMAACVKE LVFHLLAELL 3180
RTVHTLEQRR HPAGLSSSIA LQLNPCLAML MALQSELHKL YDEETQNWVS GGACGGSGGA 3240
AAGDQGRFST YFHALMEGCL AVAEVTLPTN MSVTASGVTS ATAPNLSDSS SSSSSSPGQT 3300
PQSPSLLSKR KKVKMKREKA SSSGKRQSSR TVDSDPTVLS IGGSKPEDML WFHRALTLLI 3360
ILRHLTRKDP QGLGVTSDAI ADACQALVGP TAHSRLLVIS GIPTHLDEGV VRGAIRKACN 3420
AHGGVFKDEI YIPLQEEDTK KPKDKAEGGD GKVEPEKTLA FPGTDSMEVS TSSSLTPAMS 3480
ISASASTSQA SICSSQGISQ TVSDLSVDPL PAGLELPIPP GLLEPHAVSS QESLDISLCS 3540
TGSLGSLGSL GEPLDNAETA SVSDMGSMYT VTSLDNQPLA ARPIKGFAVV EIRSRAKIEK 3600
IRASLFNNND LIGLSSLDGE DELMEMSTEE ILTVSVVNQS LFDTQGSPGL EDYFNDKSIK 3660
GEKLVPGARE VLTEIFKSCA HSEQTLSLTP AKPIRVSDIY LSKEQINSQT PGNLLHLFFT 3720
NVRPPKKVLE DQLTQILRKY GVPKPKFDKS KYSKAGKEQH PVKVVSTKRP ITKPPAKDKA 3780
VLNSVSRTAL SEKKPTVKPK SPEKSKPDEK DPEKSPTKKQ EVPEEKYLTL EGFHKFVIDR 3840
ARQDIRSVWR AILSCGYDLH FERCACIDVR HAQKASRKWT LEMDVALVQY INQLCRHLAI 3900
TPARLHPHEV YLDPADAADP RVACLLNVPI ESLRLRFALL QSLNTTLETF FLPLVELRQT 3960
PMYTHSIAAL LKEAKGLIFY DTKVTVMNRV LNATVQRTAD HAAPEITLDP LEIVGGEIRA 4020
SENSYFCQAA RQLASVPSSQ LCVKLASGGD PTYAFNIRFT GEEVHGTSGS FRHFLWQVCK 4080
ELQSSSLSLL LLCPSSAVNK NKGKYILTPS PITYGEEQLL HFLGQLLGIA IRADVPLPLD 4140
LLPSFWKTLV GEPLDPEQDL QEADILTYNY VKKFESINDE TELEALCAEI ASQHLATESP 4200
DSPNKPCCRF TYLTMTGEEV ELCSRGRHIL VAWENKDIYA AAIRSLRLRE LQNVECVTAV 4260
RAGLGSIIPL QLLTMLSPLE MELRTCGLPY INLEFLKAHT MYQVGLMETD QHIEFFWGAL 4320
EMFTQEELCK FIKFACNQER IPFTCPCKDG GPDTAHVPPY PMKIAPPDGT AGSPDSRYIR 4380
VETCMFMIKL PQYSSLEIML EKLRCAIHYR EDPLSG 4417
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity