dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0053340
Uniprot Accession I3L2J0; I3L2J0_HUMAN;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Protein capicua homolog
Protein Synonyms/Alias
Gene Name CIC
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
227VVRQVRRSQDLGVQFcurated25850435; 25849741
301AAYKVRLSPGPSSQPcurated25849741
423LPPPQLLSPPPKSPAcurated25850435; 25627689
428LLSPPPKSPAFVGPGcurated25850435; 25627689
442GRPGEQPSPCQEGSQcurated25627689
456QGGSRSSSVASLEKGcurated25627689
459SRSSSVASLEKGTAPcurated25627689
472APAARARTPLTAAQQcurated25627689
489KKGDVVCTPSGIRKKcurated25850435; 25627689
564EFDWGDETSRDSEAScurated25849741
565FDWGDETSRDSEASScurated25849741
645GFRPANFSPINASPVcurated25850435; 25849741
650NFSPINASPVIQRTAcurated25850435
664AVRSRHLSASTPKAGcurated25627689; 25003641
666RSRHLSASTPKAGVLcurated25627689
674TPKAGVLTPPDLGPHcurated25627689
693APRERHSSGILPTFQcurated25627689
710LTFTVPISPGRRKTEcurated25850435; 25627689
755GVDSVSHTPTPSTPAcurated25850435; 25849741
768PAGFRAVSPAVPFSRcurated25627689; 25404012
Sequence
(Fasta)		MKPMKKACTG LSGPGSGSKS PPATRAKALR RRGAGEGDKP EEEDDEAQQP QPQSGPEEAE 60
EGEEEEAERG PGAEGPPLEL HPGDPAPGPA EDPKGDGEAG RWEPSLSRKT ATFKSRAPKK 120
KYVEEHGAGS SGVAGAPEER VRTPEEASGL GVPPRPPTST RSSSTDTASE HSADLEDEPA 180
EACGPGPWPP GSTSGSYDLR QLRSQRVLAR RGDGLFLPAV VRQVRRSQDL GVQFPGDRAL 240
TFYEGVPGAG VDVVLDATPP PGALVVGTAV CTCVEPGVAA YREGVVVEVA TKPAAYKVRL 300
SPGPSSQPGL PGSLPQPPQP LHREPEEAVW VARSSLRLLR PPWEPETMLR KPPTGPEEEQ 360
AEPGATLPPC PAALDPKQPE DAEVSKISFG GNLGTHCEEG EEKHPPALGT PALLPLPPPQ 420
LLSPPPKSPA FVGPGRPGEQ PSPCQEGSQG GSRSSSVASL EKGTAPAARA RTPLTAAQQK 480
YKKGDVVCTP SGIRKKFNGK QWRRLCSRDG CMKESQRRGY CSRHLSMRTK EMEGLADSGP 540
GGAGRPAAVA AREGSTEFDW GDETSRDSEA SSVAARGDSR PRLVAPADLS RFEFDECEAA 600
VMLVSLGSSR SGTPSFSPVS TQSPFSPAPS PSPSPLFGFR PANFSPINAS PVIQRTAVRS 660
RHLSASTPKA GVLTPPDLGP HPPPPAPRER HSSGILPTFQ TNLTFTVPIS PGRRKTELLP 720
HPGALGAPGA GGGGAAPDFP KSDSLDSGVD SVSHTPTPST PAGFRAVSPA VPFSRSRQPS 780
PLLLLPPPAG LTSDPGPSVR RVPAVQRDSP VIVRNPDVPL PSKFPGEVGT AGEVRAGGPG 840
RGCRETPVPP GVASGKPGLP PPLPAPVPIT VPPAAPTAVA QPMPAFGLAS SPFQPVAFHP 900
SPAALLPVLV PSSYTSHPAP KKEVIMGRPG TVWTNVEPRS VAVFPWHSLV PFLAPSQPDP 960
SVQPSEAQQP ASHPVASNQS KEPAESAAVA HERPPGGTGS ADPERPPGAT CPESPGPGPP 1020
HPLGVVESGK GPPPTTEEEA SGPPGEPRLD SETESDHDDA FLSIMSPEIQ LPLPPGKRRT 1080
QSLSALPKER DSSSEKDGRS PNKREKDHIR RPMNAFMIFS KRHRALVHQR HPNQDNRTVS 1140
KILGEWWYAL GPKEKQKYHD LAFQVKEAHF KAHPDWKWCN KDRKKSSSEA KPTSLGLAGG 1200
HKETRERSMS ETGTAAAPGV SSELLSVAAQ TLLSSDTKAP GSSSCGAERL HTVGGPGSAR 1260
PRAFSHSGVH SLDGGEVDSQ ALQELTQMVS GPASYSGPKP STQYGAPGPF AAPGEGGALA 1320
ATGRPPLLPT RASRSQRAAS EDMTSDEERM VICEEEGDDD VIADDGFGTT DIDLKCKERV 1380
TDSESGDSSG EDPEGNKGFG RKVFSPVIRS SFTHCRPPLD PEPPGPPDPP VAFGKGYGSA 1440
PSSSASSPAS SSASAATSFS LGSGTFKAQE SGQGSTAGPL RPPPPGAGGP ATPSKATRFL 1500
PMDPATFRRK RPESVGGLEP PGPSVIAAPP SGGGNILQTL VLPPNKEEQE GGGARVPSAP 1560
APSLAYGAPA APLSRPAATM VTNVVRPVSS TPVPIASKPF PTSGRAEASP NDTAGARTEM 1620
GTGSRVPGGS PLGVSLVYSD KKSAAATSPA PHLVAGPLLG TVGKAPATVT NLLVGTPGYG 1680
APAPPAVQFI AQGAPGGGTT AGSGAGAGSG PNGPVPLGIL QPGALGKAGG ITQVQYILPT 1740
LPQQLQVAPA PAPAPGTKAA APSGPAPTTS IRFTLPPGTS TNGKVLAATA PTPGIPILQS 1800
VPSAPPPKAQ SVSPVQAPPP GGSAQLLPGK VLVPLAAPSM SVRGGGAGQP LPLVSPPFSV 1860
PVQNGAQPPS KIIQLTPVPV STPSGLVPPL SPATLPGPTS QPQKVLLPSS TRITYVQSAG 1920
GHALPLGTSP ASSQAGTVTS YGPTSSVALG FTSLGPSGPA FVQPLLSGQA PLLAPGQVGV 1980
SPVPSPQLPP ACAAPGGPVI TAFYSGSPAP TSSAPLAQPS QAPPSLVYTV ATSTTPPAAT 2040
ILPKGPPAPA TATPAPTSPF PSATGSMTYS LVAPKAQRPS PKAPQKVKAA IASIPVGSFE 2100
AGASGRPGPA PRQPLEPGPV REPTAPESEL EGQPTPPAPP PLPETWTPTA RSSPPLPPPA 2160
EERTSAKGPE TMASKFPSSS SDWRVPGQGL ENRGEPPTPP SPAPAPAVAP GGSSESSSGR 2220
AAGDTPERKE AAGTGKKVKV RPPPLKKTFD SVDKVLSEVD FEERFAELPE FRPEEVLPSP 2280
TLQSLATSPR AILGSYRKKR KNSTDLDSAP EDPTSPKRKM RRRSSCSSEP NTPKSAKCEG 2340
DIFTFDRTGT EAEDVLGELE YDKVPYSSLR RTLDQRRALV MQLFQDHGFF PSAQATAAFQ 2400
ARYADIFPSK VCLQLKIREV RQKIMQAATP TEQPPGAEAP LPVPPPTGTA AAPAPTPSPA 2460
GGPDPTSPSS DSGTAQAAPP LPPPPESGPG QPGWEGAPQP SPPPPGPSTA ATGR 2515
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR032147--DUF4819
IPR009071--HMG_box_dom
PROSITE

PS50118--HMG_BOX_2
Pfam

PF16090--DUF4819
PF00505--HMG_box
Gene Ontology

GO:0005634--C:nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter