dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0053292
Uniprot Accession H8ESD5; H8ESD5_CAEEL;
Genbank Protein ID NP_001255790.1;
Genbank Nucleotide ID NM_001268861.1;
Protein Name Na-K-Cl Cotransporter homolog
Protein Synonyms/Alias
Gene Name nkcc-1
Gene Synonyms/Alias CELE_Y37A1C.1;Y37A1C.1;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
80TLVTRKMSATGRFMVPhospho.ELM 9.0;PHOSIDA;curated19530675; 21081558; 18806794
128RAKGVHFSVGDKDSGPhospho.ELM 9.0;PHOSIDA;curated19530675; 21081558; 18806794
Sequence
(Fasta)		MNGNGENGTD EKQKLLSVVG VVSEEVVEMN RVSSARFQVS KTDEDEKTSD DNLRKLKSGS 60
EPPPPTQNHE AVTLVTRKMS ATGRFMVTSD TNPGQLVAEV ADELGIDVPI DPPAEKSPAS 120
RAKGVHFSVG DKDSGSMSED GDEKRNITHE NQTTFNMKSW RNMKTIEHPP IIDFYRNSID 180
TDGVFNRPSM AQLIHGKEHK EQDLGFEELN AQHHHLEDSP VHETKNEYRM EKMHAPPSQN 240
RVKFGWIQGV FVRCLLNIFG VMLYLRVSWV SGQAGVGLGS CIVLLASVVT TITALSTCAI 300
CTNGDVKGGG AYFLISRSLG PEFGGSIGII FSIANAVGAA MYIVGFAESF RDVLIDYNIG 360
TIFDGGLWDV RVIGFVTCVI LMGIVFIGSE FESKMQLGLL VILLVSIANY VFGSFFPPNE 420
IAMNRGATGY SLDTLQSNFM PHFTENNTFF SVFSVYFPAA TGIMAGANIS GDLANPQQAI 480
PLGTLLAILV TTIVYLLTVW MTGSTVVAFS NGTEPAVFNN SYFVPPDCTP DCPFGLVSYY 540
QVVEMSSFWG PLITAGIFAA TLSSALASLV SAPKVFQAVC KDRLFPRIDY FAKTYGKNEE 600
PKRAYVLGFF LAMGIVAIGD LNVIAPIISN FFLGSYALIN YACFDQSFAD SPGFRPGFTY 660
YNMWISLVGA LLCVFVMFII DWFSALVTFF CFGAIFMYLL HRKPDVNWGS STQAHSYKNA 720
LSAMIKLSTT EEHVKNYRPQ VLVLSGNPAS RSCLVDFANN ITKGSSLLVC GQVVPYEPSD 780
RVYMVMKRLD ENINVWLRKR HLKAFYRAVA NSNFRKGAQS LIQLTGIAKM KPNIVLMGFK 840
SNWYKGGPTE TNLNEMNEYF GTIQDVFDWN MAMCVLRNGQ VGLDFSEAMR NLNLIEPNRL 900
NVPPIEEKEK EKEKTNENSP ETVHLIEKDE TARTDKSGDD GSSARLSYRG SCRSVEMFQR 960
INAFYINASI SINETYVSDE NQEDADGDDD NDNDGEESGA DDEHQKEDDV ELGVIDEQEK 1020
RHFSLRRRGS RRHTVEQKAL LSSIQRFNRK VKKGTIDVWW LYDDGGLTLL IPHLLAIPKS 1080
YLEGARLRIF TISTSSRTME QEQRGMAALL SKFRIDYSDV YVIADIGKKP RQETMNTWQS 1140
VIDPFIAQDG SCPIGMTTKS ELSAQRDKTY RQLRAGELLN EHSINADLIV MTLPVPRKGM 1200
VSSSLYMSWL EVMTRNLPPV LLVRGNQQSV LTFYS 1236
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR004841--AA-permease/SLC12A_dom
IPR018491--SLC12_C
IPR004842--SLC12A_fam
PROSITE
Pfam

PF00324--AA_permease
PF03522--SLC12
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0022820--F:potassium ion symporter activity
GO:0015379--F:potassium:chloride symporter activity
GO:0015081--F:sodium ion transmembrane transporter activity
GO:0015378--F:sodium:chloride symporter activity
GO:0008511--F:sodium:potassium:chloride symporter activity
GO:0006884--P:cell volume homeostasis
GO:0055064--P:chloride ion homeostasis
GO:1902476--P:chloride transmembrane transport
GO:0055075--P:potassium ion homeostasis
GO:0010107--P:potassium ion import
GO:0055078--P:sodium ion homeostasis
GO:0035725--P:sodium ion transmembrane transport