Tag |
Content |
dbPAF ID |
dbPAF-0053176 |
Uniprot Accession |
H7BWY4; H7BWY4_MOUSE; |
Genbank Protein ID |
NP_001239363.1; |
Genbank Nucleotide ID |
NM_001252434.1; |
Protein Name |
Disks large homolog 1 |
Protein Synonyms/Alias |
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Gene Name |
Dlg1 |
Gene Synonyms/Alias |
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Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
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Phosphorylation Sites
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dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
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158 | FVSHSHISPIKANPP | PhosphoSitePlus;curated | 22135298; 25266776 |
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Sequence (Fasta) | MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL 60 LDNPKCVDHS KQCEPVQPVT TWEIASLPST AVTSETLPGS LSPPVEKYRY QDEEVLPPEH 120 ISPQVTNEVL GPELVHVSEK NLSEIENVHG FVSHSHISPI KANPPPVLVN TDSLETPTYV 180 NGTDADYEYE EITLERGNSG LGFSIAGGTD NPHIGDDSSI FITKIITGGA AAQDGRLRVN 240 DCILRVNEAD VRDVTHSKAV EALKEAGSIV RLYVKRRKPA SEKIMEIKLI KGPKGLGFSI 300 AGGVGNQHIP GDNSIYVTKI IEGGAAHKDG KLQIGDKLLA VNSVCLEEVT HEEAVTALKN 360 TSDFVYLKVA KPTSMYINDG YAPPDITNSS SQSVDNHVSP SSCLGQTPTS PARYSPISKA 420 VLGDDEITRE PRKVVLHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDRII 480 SVNSVDLRAA SHEQAAAALK NAGQAVTIVA QYRPEEYSRF EAKIHDLREQ MMNSSVSSGS 540 GSLRTSQKRS LYVRALFDYD KTKDSGLPSQ GLNFRFGDIL HVINASDDEW WQARQVTPDG 600 ESDEVGVIPS KRRVEKKERA RLKTVKFNSK TRGDKGEIPD DMGSKGLKHV TSNASDSESS 660 YRGQEEYVLS YEPVNQQEVN YTRPVIILGP MKDRVNDDLI SEFPDKFGSC VPHTTRPKRD 720 YEVDGRDYHF VTSREQMEKD IQEHKFIEAG QYNNHLYGTS VQSVRAVAEK GKHCILDVSG 780 NAIKRLQIAQ LYPISIFIKP KSMENIMEMN KRLTEEQARK TFERAMKLEQ EFTEHFTAIV 840 QGDTLEDIYN QVKQIIEEQS GPYIWVPAKE KL
873Fasta Sequence
>H7BWY4|Dlg1|Mus musculus(Mouse) MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCVDHSKQCEPVQPVTTWEIASLPSTAVTSETLPGSLSPPVEKYRYQDEEVLPPEHISPQVTNEVLGPELVHVSEKNLSEIENVHGFVSHSHISPIKANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSCLGQTPTSPARYSPISKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFRFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRGDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVPAKEKL
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Keyword |
KW-0175--Coiled coil KW-0181--Complete proteome KW-1267--Proteomics identification KW-1185--Reference proteome KW-0728--SH3 domain
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Interpro |
IPR016313--DLG1 IPR008145--GK/Ca_channel_bsu IPR008144--Guanylate_kin-like_dom IPR020590--Guanylate_kinase_CS IPR015143--L27_1 IPR004172--L27_dom IPR019590--MAGUK_PEST_N IPR027417--P-loop_NTPase IPR001478--PDZ IPR019583--PDZ_assoc IPR001452--SH3_domain
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PROSITE |
PS00856--GUANYLATE_KINASE_1 PS50052--GUANYLATE_KINASE_2 PS51022--L27 PS50106--PDZ PS50002--SH3
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Pfam |
PF00625--Guanylate_kin PF09058--L27_1 PF10608--MAGUK_N_PEST PF00595--PDZ PF10600--PDZ_assoc PF00018--SH3_1
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Gene Ontology |
GO:0005605--C:basal lamina GO:0016323--C:basolateral plasma membrane GO:0005923--C:bicellular tight junction GO:0030054--C:cell junction GO:0031253--C:cell projection membrane GO:0005911--C:cell-cell junction GO:0005737--C:cytoplasm GO:0009898--C:cytoplasmic side of plasma membrane GO:0005829--C:cytosol GO:0005783--C:endoplasmic reticulum GO:0070062--C:extracellular exosome GO:0005794--C:Golgi apparatus GO:0001772--C:immunological synapse GO:0016328--C:lateral plasma membrane GO:0045121--C:membrane raft GO:0005874--C:microtubule GO:0005902--C:microvillus GO:0097025--C:MPP7-DLG1-LIN7 complex GO:0031594--C:neuromuscular junction GO:0005634--C:nucleus GO:0033270--C:paranode region of axon GO:0048471--C:perinuclear region of cytoplasm GO:0005886--C:plasma membrane GO:0014069--C:postsynaptic density GO:0045211--C:postsynaptic membrane GO:0045202--C:synapse GO:0004385--F:guanylate kinase activity GO:0044325--F:ion channel binding GO:0035255--F:ionotropic glutamate receptor binding GO:0019900--F:kinase binding GO:0097016--F:L27 domain binding GO:0031434--F:mitogen-activated protein kinase kinase binding GO:0019902--F:phosphatase binding GO:0015459--F:potassium channel regulator activity GO:0008022--F:protein C-terminus binding GO:0032947--F:protein complex scaffold GO:0019901--F:protein kinase binding GO:0007015--P:actin filament organization GO:0032147--P:activation of protein kinase activity GO:0042982--P:amyloid precursor protein metabolic process GO:0030953--P:astral microtubule organization GO:0070830--P:bicellular tight junction assembly GO:0001658--P:branching involved in ureteric bud morphogenesis GO:0034629--P:cellular protein complex localization GO:0030866--P:cortical actin cytoskeleton organization GO:0043622--P:cortical microtubule organization GO:0048704--P:embryonic skeletal system morphogenesis GO:0001935--P:endothelial cell proliferation GO:0051660--P:establishment of centrosome localization GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity GO:0046710--P:GDP metabolic process GO:0046037--P:GMP metabolic process GO:0060022--P:hard palate development GO:0001771--P:immunological synapse formation GO:0002088--P:lens development in camera-type eye GO:0031579--P:membrane raft organization GO:0050680--P:negative regulation of epithelial cell proliferation GO:0070373--P:negative regulation of ERK1 and ERK2 cascade GO:0045930--P:negative regulation of mitotic cell cycle GO:1903753--P:negative regulation of p38MAPK cascade GO:0051898--P:negative regulation of protein kinase B signaling GO:0042130--P:negative regulation of T cell proliferation GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0007399--P:nervous system development GO:0030432--P:peristalsis GO:0030838--P:positive regulation of actin filament polymerization GO:0008284--P:positive regulation of cell proliferation GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane GO:0043268--P:positive regulation of potassium ion transport GO:0008104--P:protein localization GO:0072659--P:protein localization to plasma membrane GO:0043113--P:receptor clustering GO:0097120--P:receptor localization to synapse GO:0008360--P:regulation of cell shape GO:0042391--P:regulation of membrane potential GO:0031641--P:regulation of myelination GO:0048608--P:reproductive structure development GO:0016337--P:single organismal cell-cell adhesion GO:0048745--P:smooth muscle tissue development GO:0007268--P:synaptic transmission GO:0042110--P:T cell activation GO:0002369--P:T cell cytokine production GO:0048729--P:tissue morphogenesis GO:0001657--P:ureteric bud development
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