dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0053176
Uniprot Accession H7BWY4; H7BWY4_MOUSE;
Genbank Protein ID NP_001239363.1;
Genbank Nucleotide ID NM_001252434.1;
Protein Name Disks large homolog 1
Protein Synonyms/Alias
Gene Name Dlg1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
158FVSHSHISPIKANPPPhosphoSitePlus;curated22135298; 25266776
Sequence
(Fasta)
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL 60
LDNPKCVDHS KQCEPVQPVT TWEIASLPST AVTSETLPGS LSPPVEKYRY QDEEVLPPEH 120
ISPQVTNEVL GPELVHVSEK NLSEIENVHG FVSHSHISPI KANPPPVLVN TDSLETPTYV 180
NGTDADYEYE EITLERGNSG LGFSIAGGTD NPHIGDDSSI FITKIITGGA AAQDGRLRVN 240
DCILRVNEAD VRDVTHSKAV EALKEAGSIV RLYVKRRKPA SEKIMEIKLI KGPKGLGFSI 300
AGGVGNQHIP GDNSIYVTKI IEGGAAHKDG KLQIGDKLLA VNSVCLEEVT HEEAVTALKN 360
TSDFVYLKVA KPTSMYINDG YAPPDITNSS SQSVDNHVSP SSCLGQTPTS PARYSPISKA 420
VLGDDEITRE PRKVVLHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDRII 480
SVNSVDLRAA SHEQAAAALK NAGQAVTIVA QYRPEEYSRF EAKIHDLREQ MMNSSVSSGS 540
GSLRTSQKRS LYVRALFDYD KTKDSGLPSQ GLNFRFGDIL HVINASDDEW WQARQVTPDG 600
ESDEVGVIPS KRRVEKKERA RLKTVKFNSK TRGDKGEIPD DMGSKGLKHV TSNASDSESS 660
YRGQEEYVLS YEPVNQQEVN YTRPVIILGP MKDRVNDDLI SEFPDKFGSC VPHTTRPKRD 720
YEVDGRDYHF VTSREQMEKD IQEHKFIEAG QYNNHLYGTS VQSVRAVAEK GKHCILDVSG 780
NAIKRLQIAQ LYPISIFIKP KSMENIMEMN KRLTEEQARK TFERAMKLEQ EFTEHFTAIV 840
QGDTLEDIYN QVKQIIEEQS GPYIWVPAKE KL 873
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR016313--DLG1
IPR008145--GK/Ca_channel_bsu
IPR008144--Guanylate_kin-like_dom
IPR020590--Guanylate_kinase_CS
IPR015143--L27_1
IPR004172--L27_dom
IPR019590--MAGUK_PEST_N
IPR027417--P-loop_NTPase
IPR001478--PDZ
IPR019583--PDZ_assoc
IPR001452--SH3_domain

PROSITE

PS00856--GUANYLATE_KINASE_1
PS50052--GUANYLATE_KINASE_2
PS51022--L27
PS50106--PDZ
PS50002--SH3

Pfam

PF00625--Guanylate_kin
PF09058--L27_1
PF10608--MAGUK_N_PEST
PF00595--PDZ
PF10600--PDZ_assoc
PF00018--SH3_1

Gene Ontology

GO:0005605--C:basal lamina
GO:0016323--C:basolateral plasma membrane
GO:0005923--C:bicellular tight junction
GO:0030054--C:cell junction
GO:0031253--C:cell projection membrane
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0001772--C:immunological synapse
GO:0016328--C:lateral plasma membrane
GO:0045121--C:membrane raft
GO:0005874--C:microtubule
GO:0005902--C:microvillus
GO:0097025--C:MPP7-DLG1-LIN7 complex
GO:0031594--C:neuromuscular junction
GO:0005634--C:nucleus
GO:0033270--C:paranode region of axon
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0045202--C:synapse
GO:0004385--F:guanylate kinase activity
GO:0044325--F:ion channel binding
GO:0035255--F:ionotropic glutamate receptor binding
GO:0019900--F:kinase binding
GO:0097016--F:L27 domain binding
GO:0031434--F:mitogen-activated protein kinase kinase binding
GO:0019902--F:phosphatase binding
GO:0015459--F:potassium channel regulator activity
GO:0008022--F:protein C-terminus binding
GO:0032947--F:protein complex scaffold
GO:0019901--F:protein kinase binding
GO:0007015--P:actin filament organization
GO:0032147--P:activation of protein kinase activity
GO:0042982--P:amyloid precursor protein metabolic process
GO:0030953--P:astral microtubule organization
GO:0070830--P:bicellular tight junction assembly
GO:0001658--P:branching involved in ureteric bud morphogenesis
GO:0034629--P:cellular protein complex localization
GO:0030866--P:cortical actin cytoskeleton organization
GO:0043622--P:cortical microtubule organization
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0001935--P:endothelial cell proliferation
GO:0051660--P:establishment of centrosome localization
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0046710--P:GDP metabolic process
GO:0046037--P:GMP metabolic process
GO:0060022--P:hard palate development
GO:0001771--P:immunological synapse formation
GO:0002088--P:lens development in camera-type eye
GO:0031579--P:membrane raft organization
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1903753--P:negative regulation of p38MAPK cascade
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0042130--P:negative regulation of T cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007399--P:nervous system development
GO:0030432--P:peristalsis
GO:0030838--P:positive regulation of actin filament polymerization
GO:0008284--P:positive regulation of cell proliferation
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0043268--P:positive regulation of potassium ion transport
GO:0008104--P:protein localization
GO:0072659--P:protein localization to plasma membrane
GO:0043113--P:receptor clustering
GO:0097120--P:receptor localization to synapse
GO:0008360--P:regulation of cell shape
GO:0042391--P:regulation of membrane potential
GO:0031641--P:regulation of myelination
GO:0048608--P:reproductive structure development
GO:0016337--P:single organismal cell-cell adhesion
GO:0048745--P:smooth muscle tissue development
GO:0007268--P:synaptic transmission
GO:0042110--P:T cell activation
GO:0002369--P:T cell cytokine production
GO:0048729--P:tissue morphogenesis
GO:0001657--P:ureteric bud development