| Tag |
Content |
| dbPAF ID |
dbPAF-0053042 |
| Uniprot Accession |
H2L099; GCK1_CAEEL; H2L0A0; H2L0A1; Q6ABW4;
|
| Genbank Protein ID |
NP_001024141.1; NP_505309.1; NP_505310.2; NP_505311.3;
|
| Genbank Nucleotide ID |
NM_001028970.2; NM_072908.3; NM_072909.2; NM_072910.5;
|
| Protein Name |
Germinal center kinase 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
gck-1 |
| Gene Synonyms/Alias |
T19A5.2; |
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View all) |
Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage (PubMed:19826475). Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 (PubMed:25743393).Functional Description
Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage (PubMed:19826475). Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 (PubMed:25743393). |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MTTTSSDELP RQADDDSMKW DRIYIQKLDP EVIFTKQERI GRGSFGEVYK GIDNRTGRVV 60
AIKIIDLEQA EDEIEDIQQE IQVLSQCDSQ YVTKYFGSFL KGSKLWIIME YLGGGSALDL 120
TKSGKLDESH IAVILREILK GLEYLHSERK IHRDIKAANV LVSEHGDVKV ADFGVAGQLT 180
ETVKKRITFV GSPFWMAPEL IKQSSYDYKA DIWSLGITAI ELANGEPPHS DLHPMRVLFL 240
IPKNPPPVLQ GSQWSKPFKE FVEMCLNKDP ENRPSASTLL KHQFIKRAKK NSILVDLIER 300
AAEYRLRTGV SSDSDLDEDS DGGGGTSKWD YPTVRGPRVS ADDDGTVRQR TDRPRAQVDR 360
RSPSGSPGGT IVRGSPQVAA VAEQLRNSSV GSSGYGSGGN SASSQYATSS LPQSHTASSG 420
GATTITLGSP NGSPTSSLAR TQSMVSPSGQ RSGSAQSWEL ERGNRPMSER VSSQVSPSKY 480
NQHRTSSSNG VQGGSGGRRE YINGSGSGLN GNSSNQNHSE YSDAVRQRGP GGSGGRLDYR 540
ESHVPTSSQE NLNHGRMYGY GAPPPSREAN NVPMPRVKGA LDCSLLPAIE HLSRTRHATA 600
ALDQLRHVFR DVEDSCPGIC NELIEELMQR IAVPQVSQSD LDAAIRRLTT PPS
654Fasta Sequence
>H2L099|gck-1|Caenorhabditis elegans
MTTTSSDELPRQADDDSMKWDRIYIQKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYRLRTGVSSDSDLDEDSDGGGGTSKWDYPTVRGPRVSADDDGTVRQRTDRPRAQVDRRSPSGSPGGTIVRGSPQVAAVAEQLRNSSVGSSGYGSGGNSASSQYATSSLPQSHTASSGGATTITLGSPNGSPTSSLARTQSMVSPSGQRSGSAQSWELERGNRPMSERVSSQVSPSKYNQHRTSSSNGVQGGSGGRREYINGSGSGLNGNSSNQNHSEYSDAVRQRGPGGSGGRLDYRESHVPTSSQENLNHGRMYGYGAPPPSREANNVPMPRVKGALDCSLLPAIEHLSRTRHATAALDQLRHVFRDVEDSCPGICNELIEELMQRIAVPQVSQSDLDAAIRRLTTPPS
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0418--Kinase
KW-0460--Magnesium
KW-0469--Meiosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0896--Oogenesis
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
|
| Interpro |
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
|
| PROSITE |
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
|
| Pfam |
PF00069--Pkinase
|
| Gene Ontology |
GO:0016324--C:apical plasma membrane
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0051019--F:mitogen-activated protein kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0032147--P:activation of protein kinase activity
GO:0051321--P:meiotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0043407--P:negative regulation of MAP kinase activity
GO:0048477--P:oogenesis
GO:0007346--P:regulation of mitotic cell cycle
GO:0060281--P:regulation of oocyte development
GO:0023014--P:signal transduction by protein phosphorylation
GO:0031098--P:stress-activated protein kinase signaling cascade
|
