dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0052732
Uniprot Accession G5EGQ3; MAX2_CAEEL; G5EGS0; H2KMK1; Q9XWL8;
Genbank Protein ID NP_001076635.1; NP_001076636.1; NP_001122655.1; NP_001254363.1;
Genbank Nucleotide ID NM_001083166.2; NM_001083167.1; NM_001129183.2; NM_001267434.1;
Protein Name Serine/threonine-protein kinase max-2
Protein Synonyms/Alias Motor axon guidance protein 2;p21-activated kinase;
Gene Name max-2
Gene Synonyms/Alias Y38F1A.10;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)
Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk-1/mek-1/kgb-1 pathway (PubMed:20008556). In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc-6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons (PubMed:18499456). Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstream of Rho GTPases (PubMed:17050621, PubMed:19023419, PubMed:23390595). In association with pak-2, plays a role in embryogenesis. In association with pak-1, may be involved in spermatogenesis (PubMed:23390595).
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
145CSNGSATSPSTSVSAPhosphoPep 2.019060867
187SERNNVPSPAPVPYSPhosphoPep 2.019060867
196APVPYSESAPQLKTFPhosphoPep 2.019060867
Sequence
(Fasta)
MSTSKSSKVR IRNFIGRIFS PSDKDKDRDD EMKPSSSAMD ISQPYNTVHR VHVGYDGQKF 60
SGLPQPWMDI LLRDISLADQ KKDPNAVVTA LKFYAQSMKE NEKTKFMTTN SVFTNSDDDD 120
VDVQLTGQVT EHLRNLQCSN GSATSPSTSV SASSSSARPL TNGNNHLSTA SSTDTSLSLS 180
ERNNVPSPAP VPYSESAPQL KTFTGETPKL HPRSPFPPQP PVLPQRSKTA SAVATTTTNP 240
TTSNGAPPPV PGSKGPPVPP KPSHLKIASS TVSSGCSSPQ QYSSARSVGN SLSNGSVVST 300
TSSDGDVQLS NKENSNDKSV GDKNGNTTTN KTTVEPPPPE EPPVRVRASH REKLSDSEVL 360
NQLREIVNPS NPLGKYEMKK QIGVGASGTV FVANVAGSTD VVAVKRMAFK TQPKKEMLLT 420
EIKVMKQYRH PNLVNYIESY LVDADDLWVV MDYLEGGNLT DVVVKTELDE GQIAAVLQEC 480
LKALHFLHRH SIVHRDIKSD NVLLGMNGEV KLTDMGFCAQ IQPGSKRDTV VGTPYWMSPE 540
ILNKKQYNYK VDIWSLGIMA LEMIDGEPPY LRETPLKAIY LIAQNGKPEI KQRDRLSSEF 600
NNFLDKCLVV DPDQRADTTE LLAHPFLKKA KPLSSLIPYI RAVREK 647
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0334--Gonadal differentiation
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0346--Stress response
KW-0808--Transferase

Interpro

IPR000095--CRIB_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS50108--CRIB
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00786--PBD
PF00069--Pkinase

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0043204--C:perikaryon
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0048365--F:Rac GTPase binding
GO:0030036--P:actin cytoskeleton organization
GO:0007257--P:activation of JUN kinase activity
GO:0030154--P:cell differentiation
GO:0035262--P:gonad morphogenesis
GO:0007506--P:gonadal mesoderm development
GO:0040039--P:inductive cell migration
GO:0007254--P:JNK cascade
GO:0007399--P:nervous system development
GO:0006468--P:protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0007346--P:regulation of mitotic cell cycle
GO:0046688--P:response to copper ion
GO:0007266--P:Rho protein signal transduction