dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0052728 |
| Uniprot Accession | G5EGK5; CAM1_CAEEL; G5ECA5; Q38G54; |
| Genbank Protein ID | NP_001021907.1; NP_001021908.1; NP_001033327.1; |
| Genbank Nucleotide ID | NM_001026736.4; NM_001026737.3; NM_001038238.2; |
| Protein Name | Tyrosine-protein kinase receptor cam-1 |
| Protein Synonyms/Alias | |
| Gene Name | cam-1 |
| Gene Synonyms/Alias | kin-8;C01G6.8; |
| Organism | Caenorhabditis elegans |
| NCBI Taxa ID | 6239 |
| Functional Description (View all) |
Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom-2 and cwn-1 (PubMed:17942487, PubMed:25029443). Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development (PubMed:10476968, PubMed:9165130, PubMed:9475729, PubMed:14651925). Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2 (PubMed:25373777). In addition, plays a role in ASI sensory neuron positioning and functions (PubMed:10556063). Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth (PubMed:10476968, PubMed:14651925). Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring by controlling axon guidance of SIA and SIB neurons (PubMed:19855022). Involved in synapse plasticity by regulating delivery and/or stabilization of acetylcholine receptor acr-16 at post-synaptic membrane sites and the distribution of synaptic vesicles at pre-synaptic release sites (PubMed:15944127). Probably by acting as a receptor for Wnt ligands cwn-1 and cwn-2, negatively regulates developmental neurite pruning of AIM neurons (PubMed:19561603). Plays a role in ALM neuron polarity (PubMed:25917219). By binding Wnt ligands mom-2, cwn-1 and egl-20 and thereby restricting their availability, negatively regulates Wnt signaling. This mechanism is involved in HSN neuron and QR neuronal descendent migration, and in vulva development (PubMed:15371357, PubMed:17942487). Involved in dauer formation, locomotion, tail morphology and egg-laying (PubMed:10556063, PubMed:9475729, PubMed:14504222). May be involved in distal tip cell (DTC) migration during the development of the posterior gonad (PubMed:10556063). |
| Phosphorylation Sites |
dbPAF PTMs: 7 |
| Sequence (Fasta) | MSPRPEDDDL VIEPADDEGL HYGNASMEGT STGQRPYIRL TSQLRNATKS SGDEVRFKCE 60 ALGTPPLKFI WLKNNGPVEK TKRVKIRDKE NSSRLVITQL DVLDSGYYQC IVSNPAASVN 120 TTSVLRVNNV PDAVKLSQKK GSHHSTKHIA FDEYEDYEMM DRGRLPDEED ADLYRVPDSA 180 AGSNYAPVAV SERWLDGIKY RVGDCVQYRG EACRQYLSNK FVMMTNESRE EMYDIDRNLR 240 AAMLFINGAP TISQKCRQLS QAVACHHMYK VCESDSNNQI VSICKHDCDV IQNDECPSEL 300 ALAAQHELVG DTPKALFPLC SRLSSTSNCI PVMSTALQSS PVAEVNRGHL THWCYVNSGT 360 QYEGTVAQTS SGKQCAPWID STSRDFNVHR FPELMNSKNY CRNPGGKKSR PWCYSKPMGQ 420 EEYCDVPQCP SDMYPHLNDK KVEGSTKGGV SESVTALWDS LDPTMQVALV GGGVFFSLLL 480 LLLFCCACCC RAKKKSQKTR HQNAHCSSAP SVINSAANSA YYRKLNGTST PIMGRVPPHV 540 EMTSLLPSAQ HLGPPPYPMD QHLQQARRFP SQEPIDDNSY KVFEITPSQL SVREKIGEGQ 600 FGVVHSGIYT SGLFAPEPMA VAVKKCRHDA TNAERAQLEQ EIRAVATFDH PNVIKLIGVC 660 YMDNSLLAVF EYMVHGDLHE LLKVRVPPAD HDMGGITEAN AEFLYIATQI ALGMEYLASM 720 SFVHRDLATR NCLVGDTRTI KIADFGLMRT SYGSDYYKML HRSWMPVRWM SKEAIEQGRF 780 SEASDVWSFG VTLWEIWSFG RQPYEGASNQ QVIELVANRH LLECPHNCPT NIYSLMVECW 840 HENIERRPTF SEIRSRLQSW SLASPAHSIL QQHNNRAGSH SGSSGAGRPP THQRGYPSQK 900 LHRRVEGASP LMKRHDANYA YSEDGDSD 929 |
| Keyword | KW-0025--Alternative splicing |
| Interpro | IPR020067--Frizzled_dom |
| PROSITE | PS50038--FZ |
| Pfam | |
| Gene Ontology | GO:0030424--C:axon |