| Tag |
Content |
| dbPAF ID |
dbPAF-0052690 |
| Uniprot Accession |
G5EFU0; PK2_CAEEL; Q9U3M1;
|
| Genbank Protein ID |
NP_505809.2; NP_505810.2;
|
| Genbank Nucleotide ID |
NM_073408.3; NM_073409.4;
|
| Protein Name |
Serine/threonine-protein kinase pak-2 |
| Protein Synonyms/Alias |
p21-activated kinase 2; |
| Gene Name |
pak-2 |
| Gene Synonyms/Alias |
C45B11.1; |
| Organism |
Caenorhabditis elegans |
| NCBI Taxa ID |
6239 |
Functional Description
(View all) |
Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration.Functional Description
Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MNRTFSLRRK VKKSEISTPS NFEHRIHAGF DARSGTYTGL PKQWQALLGP PRSISRPKPM 60
VDPSCITPVD VAELKTVIRG PSSSFRYNSP LPFGMTNSPM PSVARSNSLR ISATASPVVN 120
VSSARHSFRP TLPPVSQRGY PFNDPSYAPL PLRNQKPPMS TTFGVEKPHQ YQQIITIVAP 180
SRTTTPQLQP KSPSTPQAMR QQPKCTEGVS DEEFRNALKF VVDGTDPRSD LTDYKQIGEG 240
STGVVEAAYK ISTKQIVAVK RMNLRKQQRR ELLFNEVSIL RQYQHPNIVR FFSSHLVDDE 300
LWVVMEFMEG GSLTDIVTAT RMTEPQIATI SRQVLGALDF LHARKVIHRD IKSDSILLKR 360
DGTVKLTDFG FCGQLSEEVP RRRSLVGTPY WTAAEVIARE PYDTRADIWS FGIMLIEMVE 420
GEPPFFNDQP FQAMKRIRDE HEARFSRHAK VSVELSELLS HCIVKDVNKR WPAKDLLRHP 480
FFAKAQHSSS IAPLLLQLQG NTINGNNPPT HHHSSQITTV IQ
523Fasta Sequence
>G5EFU0|pak-2|Caenorhabditis elegans
MNRTFSLRRKVKKSEISTPSNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAELKTVIRGPSSSFRYNSPLPFGMTNSPMPSVARSNSLRISATASPVVNVSSARHSFRPTLPPVSQRGYPFNDPSYAPLPLRNQKPPMSTTFGVEKPHQYQQIITIVAPSRTTTPQLQPKSPSTPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIAPLLLQLQGNTINGNNPPTHHHSSQITTVIQ
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
|
| Interpro |
IPR000095--CRIB_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
|
| PROSITE |
PS50108--CRIB
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
|
| Pfam |
PF00786--PBD
PF00069--Pkinase
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0048365--F:Rac GTPase binding
GO:0030036--P:actin cytoskeleton organization
GO:0032147--P:activation of protein kinase activity
GO:0016477--P:cell migration
GO:0042981--P:regulation of apoptotic process
GO:0043408--P:regulation of MAPK cascade
GO:0007346--P:regulation of mitotic cell cycle
GO:0007266--P:Rho protein signal transduction
GO:0023014--P:signal transduction by protein phosphorylation
GO:0031098--P:stress-activated protein kinase signaling cascade
|
