dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0052686 | ||||||||
| Uniprot Accession | G5EFS4; DCPS_CAEEL; | ||||||||
| Genbank Protein ID | NP_001256897.1; | ||||||||
| Genbank Nucleotide ID | NM_001269968.1; | ||||||||
| Protein Name | m7GpppX diphosphatase | ||||||||
| Protein Synonyms/Alias | Decapping scavenger enzyme;Heat shock-like protein;Protein DCS-1;Scavenger mRNA-decapping enzyme DcpS; | ||||||||
| Gene Name | dcs-1 | ||||||||
| Gene Synonyms/Alias | hsl-1;Y113G7A.9; | ||||||||
| Organism | Caenorhabditis elegans | ||||||||
| NCBI Taxa ID | 6239 | ||||||||
| Functional Description (View all) |
Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to m(7)GMP and m3(2,2,7)GMP, respectively (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by dcs-1 to m7GMP. Binds to m7GpppG and strongly to m7GDP. | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MKRIADEELV REERAEESTQ KWLQDAKFQE ILGADSSHKS LFVLLSHPDG SQGILLANKS 60 PFSEEKSDIE KLLATAQLQE ISRNDIFGSY NIEIDPKLNL LKSQLIYPIN DRLIAKYRQE 120 EKFVIRETPE LYETVTRPYI EKYQLNLNWV YNCLEKRSEV DKIVFEDPDN ENGFVLLQDI 180 KWDGKTLENL YVLAICHRHG LKSVRDLTGD DLEMLYNMRD KSLEAINQKY GLKTDQIKCY 240 FHYQPSFYHL HVHFINLKYD APASTTMSAI LLDDVINNLE LNPEHYKKST LTFTRKNGDK 300 LMEMFREALK N 312 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR008594--DcpS/DCS2 |
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| PROSITE | |||||||||
| Pfam | PF05652--DcpS |
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| Gene Ontology | GO:0005737--C:cytoplasm |