dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0052682
Uniprot Accession G5EFR6; G5EFR6_CAEEL;
Genbank Protein ID NP_501709.2;
Genbank Nucleotide ID NM_069308.5;
Protein Name Calcium-transporting ATPase
Protein Synonyms/Alias
Gene Name mca-1
Gene Synonyms/Alias 4K392;CELE_W09C2.3;W09C2.3;
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Functional Description
(View all)
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
1201ETAESVKSADWAKEQPhospho.ELM 9.0;PHOSIDA;curated19530675; 21081558; 18806794
1226KQVARGKSLDKDSKKPhospho.ELM 9.0;PHOSIDA;curated19530675; 21081558; 18806794
Sequence
(Fasta)
MQKSQNVTAV TETNGVAAAL GGHHTSPDTN AGKTKDAKEF GCSLGDLRGL MEARGAEAIV 60
RLSTEHEGVE GLCKKLKTDS LVGLNGEQAD LDRRRHVYGA NTIPPAKSKG FVRLVLDACK 120
DPTLVILVLS GFINLALSFY EPTSAAEDAT QHLVNATTAA ILANGTFMST TEAPSEGHGT 180
AWIEGVAILL CVIVVVLVTA VNDYSKERQF RSLQEKIETG QKFSVIRNGE AIDVPVSDLV 240
VGDIARVKYG DLLPADGFLI QSNDLKIDES SLTGESDHIK KSIESDPVLL SGTYAMEGSG 300
KMLITAVGVN SQTGIIMTLL GAGKAGIGDD DSTSTSSSSS SSSSSSGSSS NGSSDSSKSG 360
DDDLTAKSVL QAKLSKLALQ IIYCGTTIAI IALIVLVTRF CLDHYVFEKN EFSLVDIQMF 420
VKFFIIAVTI LVISIPEGLP LAIALALTYS VRKMMHDNNL VRHLDACETM GNATSICSDK 480
TGTLTTNRMT VVQSYINGNH YTSQEAQPHG ANLPGSTGPI LMEAISVNCA YNSMIVEPTK 540
AGEQIQQLGN KTECGLLGFV NRLGGDYAAI RKKFPEHDLT KVYTFNSSRK CMMTVVPYAE 600
NGQNIGYRVY CKGASEIVLG RCTYLIGSDG KPHQLTGDRL KEITSTIIHE MANSGLRTIC 660
VAYKTIIKKG TRDVEKTEIE FAEDSDIDWD DEDAMYQNFT GIAICGIQDP VRPEVPVAIS 720
KCKKAGITVR MVTGDNIMTA RAIAMSCKIL EPGEDFLALE GKEFNERIRD ENGKVSQAKL 780
DEIWPRLRVL ARAQPADKYT LVKGIIDSKA TPQREIVAVT GDGTNDGPAL KKADVGFAMG 840
IAGTDVAKEA SDIILTDDNF TSIVKAVMWG RNVYDSISKF LQFQLTVNVV AVITAFVGAV 900
TVSDSPLKAV HMLWINLIMD TLASLALATE QPTDELLERK PYGRKKSLIS RTMVKNILCH 960
ALYQLIIIFV IFFYGDTIFG IKTGLYAPLF APPSQHFTLV FNAFVMMTVF NEINARKVHG 1020
ERNVFKGLAS NRVFCVIWVT TFIAQIIIVQ FGGAWFSTAP LTLQQWIVCL VLGFSTLIWG 1080
QIVATIPSKK LPKAWKVGKG EVQPANLHIN GDYNVRARSR AVTLRRSGKS LWVRGMFIIG 1140
NHLRVLRAFG MEKSEKAAFG RTAPAMTAEA AERWRASYRK YRHQKHQEKK ATAETAESVK 1200
SADWAKEQKE KKKTFKQIKQ VARGKSLDKD SKKHHKKRKD QTNVDMEDIE LN 1253
Keyword

KW-0067--ATP-binding
KW-0106--Calcium
KW-0109--Calcium transport
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0406--Ion transport
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport

Interpro

IPR006068--ATPase_P-typ_cation-transptr_C
IPR004014--ATPase_P-typ_cation-transptr_N
IPR023299--ATPase_P-typ_cyto_domN
IPR018303--ATPase_P-typ_P_site
IPR023298--ATPase_P-typ_TM_dom
IPR008250--ATPase_P-typ_transduc_dom_A
IPR023214--HAD-like_dom
IPR006408--P-type_ATPase_IIB
IPR001757--P_typ_ATPase

PROSITE

PS00154--ATPASE_E1_E2

Pfam

PF00689--Cation_ATPase_C
PF00690--Cation_ATPase_N
PF00122--E1-E2_ATPase
PF08282--Hydrolase_3

Gene Ontology

GO:0005829--C:cytosol
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005524--F:ATP binding
GO:0005388--F:calcium-transporting ATPase activity
GO:0005516--F:calmodulin binding
GO:0046872--F:metal ion binding
GO:0030165--F:PDZ domain binding
GO:0006816--P:calcium ion transport
GO:0098655--P:cation transmembrane transport
GO:0006874--P:cellular calcium ion homeostasis
GO:0051480--P:cytosolic calcium ion homeostasis