dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0052669 | ||||||||
| Uniprot Accession | G5EFF5; DAF12_CAEEL; G5EBZ6; G5EG55; Q2XN07; | ||||||||
| Genbank Protein ID | NP_001024547.1; NP_001024548.1; NP_001024549.1; NP_001041239.1; | ||||||||
| Genbank Nucleotide ID | NM_001029376.4; NM_001029377.3; NM_001029378.1; NM_001047774.2; | ||||||||
| Protein Name | Nuclear hormone receptor family member daf-12 | ||||||||
| Protein Synonyms/Alias | Abnormal dauer formation protein 12; | ||||||||
| Gene Name | daf-12 | ||||||||
| Gene Synonyms/Alias | F11A1.3; | ||||||||
| Organism | Caenorhabditis elegans | ||||||||
| NCBI Taxa ID | 6239 | ||||||||
| Functional Description (View all) |
Nuclear receptor which binds directly to response elements in target gene promoters (PubMed:9477318, PubMed:10859169, PubMed:15314028, PubMed:15489294, PubMed:15383841, PubMed:15611047, PubMed:16626392, PubMed:19828440, PubMed:21814518). Activity is modulated by binding of steroid hormone ligands that include dafachronic acids (PubMed:16529801). Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues (PubMed:9477318, PubMed:10859169, PubMed:15489294, PubMed:15383841, PubMed:16626392, PubMed:19828440, PubMed:21814518). Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1 (PubMed:19828440). Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs (PubMed:23990780). Controls expression of genes that promote the aerobic catabolism of fatty acids for reproductive growth (PubMed:25774872). | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MGTNGGVIAE QSMEIETNEN PDKVEEPVVR RKRVTRRRHR RIHSKNNCLT PPNSDDDPQM 60 STPDDPVIHS PPSIGAAPGM NGYHGSGVKL EESSGACGSP DDGLLDSSEE SRRRQKTCRV 120 CGDHATGYNF NVITCESCKA FFRRNALRPK EFKCPYSEDC EINSVSRRFC QKCRLRKCFT 180 VGMKKEWILN EEQLRRRKNS RLNNTGTCNK RSQPGNQQSP QGPNQQPHLS PHHPGVAIYP 240 PQPQRPLTIN PMDNQMMHHM QANRPNAMPQ LISPPGAQPY PLTSPVGSSA SDSPPNRSLT 300 MMHNGEKSPD GYDPNIMAHR APPPSFNNRP KMDSGQVVLS TEEYKQLLSR IPGAQVPGLM 360 NEEEPINKRA AYNCNGHPMP AETTPPYSAP MSDMSLSRHN STSSGTEKNH MTHSTVSAIP 420 GNSAQNHFDI ASFGMGIVTA TGGGDAAEEM YKRMNMFYEN CIQSALDSPE NQEPKPQEAM 480 IPKEEYMTPT HGFQYQSDPY QVPPAERNIN YQLNAAELKA LDAVREAFYG MDDPMEQGRQ 540 MQSFLKANKT PADIMNIMDV TMRRFVKVAK GVPAFREVSQ EGKFSLLKGG MIEMLTVRGV 600 TRYDASTNSF KTPTIKGQNV SVNVDDMFAK LNANAQAQKA KCLEFFGFFD EEIKKNELAV 660 YLVMLAVLFS VRSDPPMNEN DVRIVTERHN HFMSLLNRYL ESLFGEQARR IFERIPKALG 720 LLNEIARNAG MLFMGTVRSG EAEELPGEFF KIK 754 |
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| Keyword | KW-0024--Alternative initiation |
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| Interpro | IPR000536--Nucl_hrmn_rcpt_lig-bd |
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| PROSITE | |||||||||
| Pfam | |||||||||
| Gene Ontology | GO:0005634--C:nucleus |