dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052422
Uniprot Accession G5E8K5; ANK3_MOUSE; G5E8K4; O08866; O08867; Q3TSJ8; Q4U205; Q4U206; Q4U256; Q4U260; Q61305; Q61306; Q61307; Q61308; Q61309; Q61310; Q8CBN3; Q8VC68;
Genbank Protein ID NP_033800.2; NP_666117.2; NP_733788.2; NP_733789.1; NP_733790.2; NP_733791.2; NP_733924.2; NP_733925.2; NP_733926.2; XP_006513202.1;
Genbank Nucleotide ID NM_009670.4; NM_146005.3; NM_170687.3; NM_170688.2; NM_170689.2; NM_170690.2; NM_170728.2; NM_170729.2; NM_170730.2; XM_006513139.2;
Protein Name Ankyrin-3
Protein Synonyms/Alias
Gene Name Ank3
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).
Phosphorylation Sites
 dbPAF PTMs: 49 (View all)
PositionPeptidesSourceReferences ( PMIDs )
22RKRKGKKSDANASYLcurated25338131
27KKSDANASYLRAARAPhosphoSitePlus;curated22135298; 25338131
247RAAAVDFTARNDITPcurated22807455
484AKAKDDQTPLHISARPhosphoSitePlus22135298
507QLLQQGASPNAATTSPHOSIDA;PhosphoSitePlus21081558; 22135298
606LLLDQGASPHAAAKNPHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated21081558; 22135298; 18056256; 19366988; 21183079
793ARRLGYISVVDTLKVPhosphoSitePlus22135298
830MNEVLDMSDDEVRKAPhosphoSitePlus;UniProt;curated22135298; 21183079; 25338131
844ASAPEKLSDGEYISDPhosphoSitePlus;curated22135298; 21183079; 25338131
848EKLSDGEYISDGEEGPhosphoSitePlus22135298
850LSDGEYISDGEEGDKPhosphoSitePlus;UniProt;curated22135298; 21183079; 25338131
873VQEVLVKSEDAITGDPhosphoSitePlus;UniProt;curated22135298; 21183079
881EDAITGDTDKYLGPQPhosphoSitePlus22135298
884ITGDTDKYLGPQDLKcurated21183079
897LKELGDDSLPAEGYVPhosphoSitePlus;curated22135298; 25338131
914SLGARSASLRSFSSDPhosphoSitePlus;curated22135298; 21743459; 21183079; 25338131
917ARSASLRSFSSDRSYPhosphoSitePlus;curated22135298; 21743459; 21183079; 25338131
919SASLRSFSSDRSYTLPhosphoSitePlus;curated22135298; 21183079; 25338131
920ASLRSFSSDRSYTLNPhosphoSitePlus;curated22135298; 21183079; 25338131
923RSFSSDRSYTLNRSSPhosphoSitePlus;UniProt;curated22135298; 21183079; 25338131
Sequence
(Fasta)		MSEEPKEKPA KPAHRKRKGK KSDANASYLR AARAGHLEKA LDYIKNGVDV NICNQNGLNA 60
LHLASKEGHV EVVSELLQRE ANVDAATKKG NTALHIASLA GQAEVVKVLV TNGANVNAQS 120
QNGFTPLYMA AQENHLEVVR FLLDNGASQS LATEDGFTPL AVALQQGHDQ VVSLLLENDT 180
KGKVRLPALH IAARKDDTKA AALLLQNDTN ADVESKSGFT PLHIAAHYGN INVATLLLNR 240
AAAVDFTARN DITPLHVASK RGNANMVKLL LDRGAKIDAK TRDGLTPLHC GARSGHEQVV 300
EMLLDRSAPI LSKTKNGLSP LHMATQGDHL NCVQLLLQHN VPVDDVTNDY LTALHVAAHC 360
GHYKVAKVLL DKKASPNAKA LNGFTPLHIA CKKNRIRVME LLLKHGASIQ AVTESGLTPI 420
HVAAFMGHVN IVSQLMHHGA SPNTTNVRGE TALHMAARSG QAEVVRYLVQ DGAQVEAKAK 480
DDQTPLHISA RLGKADIVQQ LLQQGASPNA ATTSGYTPLH LAAREGHEDV AAFLLDHGAS 540
LSITTKKGFT PLHVAAKYGK LEVASLLLQK SASPDAAGKS GLTPLHVAAH YDNQKVALLL 600
LDQGASPHAA AKNGYTPLHI AAKKNQMDIA TSLLEYGADA NAVTRQGIAS VHLAAQEGHV 660
DMVSLLLSRN ANVNLSNKSG LTPLHLAAQE DRVNVAEVLV NQGAHVDAQT KMGYTPLHVG 720
CHYGNIKIVN FLLQHSAKVN AKTKNGYTAL HQAAQQGHTH IINVLLQNNA SPNELTVNGN 780
TALAIARRLG YISVVDTLKV VTEEIMTTTT ITEKHKMNVP ETMNEVLDMS DDEVRKASAP 840
EKLSDGEYIS DGEEGDKCTW FKIPKVQEVL VKSEDAITGD TDKYLGPQDL KELGDDSLPA 900
EGYVGFSLGA RSASLRSFSS DRSYTLNRSS YARDSMMIEE LLVPSKEQHL TFTREFDSDS 960
LRHYSWAADT LDNVNLVSSP VHSGFLVSFM VDARGGSMRG SRHHGMRIII PPRKCTAPTR 1020
ITCRLVKRHK LANPPPMVEG EGLASRLVEM GPAGAQFLGP VIVEIPHFGS MRGKERELIV 1080
LRSENGETWK EHQFDSKNED LAELLNGMDE ELDSPEELGT KRICRIITKD FPQYFAVVSR 1140
IKQESNQIGP EGGILSSTTV PLVQASFPEG ALTKRIRVGL QAQPVPEETV KKILGNKATF 1200
SPIVTVEPRR RKFHKPITMT IPVPPPSGEG VSNGYKGDAT PNLRLLCSIT GGTSPAQWED 1260
ITGTTPLTFI KDCVSFTTNV SARFWLADCH QVLETVGLAS QLYRELICVP YMAKFVVFAK 1320
TNDPVESSLR CFCMTDDRVD KTLEQQENFE EVARSKDIEV LEGKPIYVDC YGNLAPLTKG 1380
GQQLVFNFYS FKENRLPFSI KIRDTSQEPC GRLSFLKEPK TTKGLPQTAV CNLNITLPAH 1440
KKAEKADRRQ SFASLALRKR YSYLTEPSMS PQSPCERTDI RMAIVADHLG LSWTELAREL 1500
NFSVDEINQI RVENPNSLIS QSFMLLKKWV TRDGKNATTD ALTSVLTKIN RIDIVTLLEG 1560
PIFDYGNISG TRSFADENNV FHDPVDGHPS FQVELETPMG LYCTPPNPFQ QDDHFSDISS 1620
IESPFRTPSR LSDGLVPSQG NIEHPTGGPP VVTAEDTSLE DSKMDDSVTV TDPADPLDVD 1680
ESQLKDLCQS ECAQCWASVP GIPNDGRQAE PLRPQTRKVG MSSEQQEKGK SGPDEEVTED 1740
KVKSLFEDIQ LEEVEAEEMT EDQGQAMLNR VQRAELAMSS LAGWQNETPS GSLESPAQAR 1800
RLTGGLLDRL DDSSDQARDS ITSYLTGEPG KIEANGNHTA EVIPEAKAKP YFPESQNDIG 1860
KQSIKENLKP KTHGCGRTEE PVSPLTAYQK SLEETSKLVI EDAPKPCVPV GMKKMTRTTA 1920
DGKARLNLQE EEGSTRSEPK QGEGYKVKTK KEIRNVEKKT H 1962
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1017--Isopeptide bond
KW-0458--Lysosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0832--Ubl conjugation
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR000906--ZU5_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50017--DEATH_DOMAIN
PS51145--ZU5
Pfam

PF12796--Ank_2
PF13606--Ank_3
PF00531--Death
PF00791--ZU5
Gene Ontology

GO:0030424--C:axon
GO:0043194--C:axon initial segment
GO:0009925--C:basal plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005923--C:bicellular tight junction
GO:0005856--C:cytoskeleton
GO:0014704--C:intercalated disc
GO:0016328--C:lateral plasma membrane
GO:0005764--C:lysosome
GO:0016020--C:membrane
GO:0033268--C:node of Ranvier
GO:0033270--C:paranode region of axon
GO:0045211--C:postsynaptic membrane
GO:0042383--C:sarcolemma
GO:0045202--C:synapse
GO:0044325--F:ion channel binding
GO:0005200--F:structural constituent of cytoskeleton
GO:0007411--P:axon guidance
GO:0007409--P:axonogenesis
GO:0071286--P:cellular response to magnesium ion
GO:0045184--P:establishment of protein localization
GO:0043001--P:Golgi to plasma membrane protein transport
GO:0010960--P:magnesium ion homeostasis
GO:0072660--P:maintenance of protein location in plasma membrane
GO:0071709--P:membrane assembly
GO:0000281--P:mitotic cytokinesis
GO:1902260--P:negative regulation of delayed rectifier potassium channel activity
GO:0019228--P:neuronal action potential
GO:0007009--P:plasma membrane organization
GO:0045760--P:positive regulation of action potential
GO:0072659--P:protein localization to plasma membrane
GO:0072661--P:protein targeting to plasma membrane
GO:0007165--P:signal transduction
GO:0050808--P:synapse organization