dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0052419
Uniprot Accession G5E8J6; G5E8J6_MOUSE;
Genbank Protein ID NP_034603.2;
Genbank Nucleotide ID NM_010473.2;
Protein Name Histidine rich calcium binding protein, isoform CRA_a
Protein Synonyms/Alias
Gene Name Hrc
Gene Synonyms/Alias mCG_23168;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 37 (View all)
PositionPeptidesSourceReferences ( PMIDs )
81REEGEDFSREYGHRVPhosphoSitePlus22135298
104EVGEENVSEEVFRGHPhosphoSitePlus;SysPTM 2.0;curated22135298; 17242355; 19366988; 22817900; 21183079; 24723360
129DNEDLGDSAENHLPRPhosphoSitePlus;curated22135298; 22817900; 21183079; 24723360
139NHLPRQRSHSHEDEDPhosphoSitePlus;curated22135298; 24723360
141LPRQRSHSHEDEDGIPhosphoSitePlus;SysPTM 2.0;curated22135298; 17242355; 19366988; 22817900; 21183079; 24723360
150EDEDGIVSSEYHRHVPhosphoSitePlus;SysPTM 2.0;curated22135298; 17242355; 19366988; 22817900; 21183079; 23882026
151DEDGIVSSEYHRHVPPhosphoSitePlus;curated22135298; 21183079; 24723360
153DGIVSSEYHRHVPRHPhosphoSitePlus;curated22135298; 24723360
212DELHHAHSHRHQGHSPhosphoSitePlus22135298
229DDDDGVSTEHGHQAHPhosphoSitePlus22135298
249EEEDDGDSDEDSHTHPhosphoSitePlus;curated22135298; 22817900; 21183079; 23882026
272NDDEDGDSGEYRHHTPhosphoSitePlus;curated22135298; 22817900; 21183079
279SGEYRHHTQDHQGHNPhosphoSitePlus22135298
305DDEDKEDSTEHRHQTPhosphoSitePlus22135298
324KEEDEDESDEDDHHVPhosphoSitePlus;curated22135298; 22817900; 21183079; 23882026
332DEDDHHVSRHGRQGYPhosphoSitePlus22135298
339SRHGRQGYEEEEDDDPhosphoSitePlus22135298
354DDDGDDDSTEHVHQAPhosphoSitePlus;curated22135298; 22817900; 21183079
355DDGDDDSTEHVHQAHPhosphoSitePlus22135298
376HKDDEDDSEEDYHHVPhosphoSitePlus22135298
Sequence
(Fasta)
MGFQGPWLHT CLLWATVAIL LVPPVVTQEL RGAGLGLGNW NNNAGIPGSS EDLSTEFGHH 60
IHRGYQGEKD RGHREEGEDF SREYGHRVQD HRYPGREVGE ENVSEEVFRG HVRQLHGHRE 120
HDNEDLGDSA ENHLPRQRSH SHEDEDGIVS SEYHRHVPRH AHHGHGEEDD DDDGGEEEER 180
VDVMEDSDDN EHQVHGHQSH SKERDELHHA HSHRHQGHSD DDDDDGVSTE HGHQAHRYQD 240
HEEEDDGDSD EDSHTHRVQG REDENDDEDG DSGEYRHHTQ DHQGHNEEQD DDDDDDDDDE 300
DKEDSTEHRH QTQGHRKEED EDESDEDDHH VSRHGRQGYE EEEDDDDDDG DDDSTEHVHQ 360
AHRHRDHEHK DDEDDSEEDY HHVPSHGRQS HQNEEEEDEA VSTEHWHQSP RHAHHDLGRE 420
SEEEVAVKYS HHVASHRPQG HNADREEDSL EEHMNEVPGH HHHRASRGDD EDISTEFGHK 480
APSHRLQDQD ERARQGHREP VQGEIAHQPL QPTGPSSRES RKEGDHSSQE GDEDPEQRQA 540
HSEEEKEEEE EEEEEEEEEK EGGHSLPMSQ EDDEEEEKDE KESKVDRAAV SAPLSHHRKQ 600
GEEEEEEEEE EEEEILEENL LPFTIIPNPL AGREVAREGS SEEESREVTG QQDAQEYENY 660
QPGSLCGYCS FCNRCTECES CHCDEENMGE HCDQCQHCQF CYLCPLVCDT LCTPGSYVDY 720
FSSSLYQALA DMLETPEP 739
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0732--Signal

Interpro

IPR015666--His-rich_Ca-bd
IPR019552--Hist_rich_Ca-bd

PROSITE
Pfam

PF10529--Hist_rich_Ca-bd

Gene Ontology

GO:0005829--C:cytosol
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0030018--C:Z disc
GO:0005509--F:calcium ion binding
GO:0044325--F:ion channel binding
GO:0055074--P:calcium ion homeostasis
GO:0051481--P:negative regulation of cytosolic calcium ion concentration
GO:0045823--P:positive regulation of heart contraction
GO:0010460--P:positive regulation of heart rate
GO:1901899--P:positive regulation of relaxation of cardiac muscle
GO:0010881--P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:1901844--P:regulation of cell communication by electrical coupling involved in cardiac conduction
GO:0008016--P:regulation of heart contraction
GO:0002027--P:regulation of heart rate
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:0060314--P:regulation of ryanodine-sensitive calcium-release channel activity