dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052405
Uniprot Accession G5E884; G5E884_MOUSE;
Genbank Protein ID NP_035165.2;
Genbank Nucleotide ID NM_011035.2;
Protein Name Non-specific serine/threonine protein kinase
Protein Synonyms/Alias
Gene Name Pak1
Gene Synonyms/Alias mCG_7049;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
174TPAVPPVSEDEDDDDcurated23984901
Sequence
(Fasta)		MSNNGVDIQD KPPAPPMRNT STMIGAGSKD TGTLNHGSKP LPPNPEEKKK KDRFYRSILP 60
GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN 120
PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNTLN VKTVSETPAV PPVSEDEDDD 180
DDATPPPVIA PRPEHTKSVY TRSVIEPLPV TPTRDVATSP ISPTENNTTP PDALTRNTEK 240
QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM 300
NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGDELW VVMEYLAGGS LTDVVTETCM 360
DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR 420
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT 480
PELQNPEKLS AIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIAAAKEAT 540
KNNH 545
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR000095--CRIB_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS50108--CRIB
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00786--PBD
PF00069--Pkinase
Gene Ontology

GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0030426--C:growth cone
GO:0071437--C:invadopodium
GO:0097481--C:neuronal postsynaptic density
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0001726--C:ruffle
GO:0005524--F:ATP binding
GO:0005518--F:collagen binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0048365--F:Rac GTPase binding
GO:0030036--P:actin cytoskeleton organization
GO:0031532--P:actin cytoskeleton reorganization
GO:0032147--P:activation of protein kinase activity
GO:0021764--P:amygdala development
GO:0048754--P:branching morphogenesis of an epithelial tube
GO:0016477--P:cell migration
GO:0071407--P:cellular response to organic cyclic compound
GO:0016358--P:dendrite development
GO:0060996--P:dendritic spine development
GO:0061534--P:gamma-aminobutyric acid secretion, neurotransmission
GO:0061535--P:glutamate secretion, neurotransmission
GO:0060244--P:negative regulation of cell proliferation involved in contact inhibition
GO:0007528--P:neuromuscular junction development
GO:0098597--P:observational learning
GO:0030335--P:positive regulation of cell migration
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0043507--P:positive regulation of JUN kinase activity
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0001934--P:positive regulation of protein phosphorylation
GO:0051496--P:positive regulation of stress fiber assembly
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0043113--P:receptor clustering
GO:0042981--P:regulation of apoptotic process
GO:0010468--P:regulation of gene expression
GO:1900271--P:regulation of long-term synaptic potentiation
GO:0043408--P:regulation of MAPK cascade
GO:0007346--P:regulation of mitotic cell cycle
GO:0007266--P:Rho protein signal transduction
GO:0023014--P:signal transduction by protein phosphorylation
GO:0031098--P:stress-activated protein kinase signaling cascade
GO:0042060--P:wound healing