dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052397
Uniprot Accession G5E829; AT2B1_MOUSE;
Genbank Protein ID NP_080758.1; XP_011241851.1;
Genbank Nucleotide ID NM_026482.2; XM_011243549.1;
Protein Name Plasma membrane calcium-transporting ATPase 1
Protein Synonyms/Alias
Gene Name Atp2b1
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Involved in bone homeostasis. Has a role in osteoclastogenesis where it regulates RANKL-induced calcium oscillation, a key step in the differentiation process. Also promotes survival of mature osteoclasts, probably by preventing toxic accumulation of intracellular calcium.
Phosphorylation Sites
 dbPAF PTMs: 31 (View all)
PositionPeptidesSourceReferences ( PMIDs )
8MGDMANNSVAYSGVKPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 25338131
17AYSGVKNSLKEANHDPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 21081558; 22135298; 17242355; 19366988; 21183079;
32GDFGITLTELRALMEPhosphoSitePlus22135298
72TSPNEGLSGNPADLEPhosphoSitePlus22135298
242DLKIDESSLTGESDHcurated25338131
264DPLLLSGTHVMEGSGPhosphoSitePlus22135298
270GTHVMEGSGRMVVTAPhosphoSitePlus22135298
338MEMQPLKSEEGGDGDPhospho.ELM 9.0;PhosphoSitePlus;UniProt;curated19144319; 22135298; 21183079; 22817900; 25338131
580YKVYTFNSVRKSMSTPHOSIDA;PhosphoSitePlus21081558; 22135298
720NTARAIATKCGILHPPhosphoSitePlus22135298
786GIIDSTVSEQRQVVAPHOSIDA;PhosphoSitePlus21081558; 22135298
799VAVTGDGTNDGPALKPHOSIDA;PhosphoSitePlus21081558; 22135298
826TDVAKEASDIILTDDPhosphoSitePlus22135298
1034GGKPFSCSELSIEQWPhosphoSitePlus22135298
1126RVVNAFRSSLYEGLEPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21081558; 19060867; 22135298; 23984901; 25338131
1127VVNAFRSSLYEGLEKPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21081558; 19060867; 22135298; 25338131
1137EGLEKPESRSSIHNFPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated21081558; 19060867; 22135298; 20047950
1139LEKPESRSSIHNFMTPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 22817900; 21183079; 25338131
1140EKPESRSSIHNFMTHPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 23684622; 23567750; 25338131
1155PEFRIEDSEPHIPLIPhospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated19144319; 21081558; 22135298; 17203969; 19366988; 17242355;
Sequence
(Fasta)		MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LTELRALMEL RSTDALRKIQ ESYGDVYGIC 60
TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV 120
SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ 180
FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE 240
SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK 300
KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS 360
VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF 420
IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL 480
TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH 540
VGNKTECALL GFLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSFRIFS 600
KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP 660
EPEWDNENDV VTGLTCIAVV GIEDPVRPEV PEAIKKCQRA GITVRMVTGD NINTARAIAT 720
KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI 780
IDSTVSEQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK 840
AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL 900
ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR 960
NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ 1020
IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE 1080
IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQIRV VNAFRSSLYE GLEKPESRSS 1140
IHNFMTHPEF RIEDSEPHIP LIDDTDAEDD APTKRNSSPP PSPNKNNNAV DSGIHLTIEM 1200
NKSATSSSPG SPLHSLETSL 1221
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0106--Calcium
KW-0109--Calcium transport
KW-0112--Calmodulin-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0406--Ion transport
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR030319--ATP2B1/4
IPR022141--ATP_Ca_trans_C
IPR006068--ATPase_P-typ_cation-transptr_C
IPR004014--ATPase_P-typ_cation-transptr_N
IPR023299--ATPase_P-typ_cyto_domN
IPR018303--ATPase_P-typ_P_site
IPR023298--ATPase_P-typ_TM_dom
IPR008250--ATPase_P-typ_transduc_dom_A
IPR023214--HAD-like_dom
IPR006408--P-type_ATPase_IIB
IPR001757--P_typ_ATPase
PROSITE

PS00154--ATPASE_E1_E2
Pfam

PF12424--ATP_Ca_trans_C
PF00689--Cation_ATPase_C
PF00690--Cation_ATPase_N
PF00122--E1-E2_ATPase
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0030054--C:cell junction
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0032591--C:dendritic spine membrane
GO:0070062--C:extracellular exosome
GO:0005887--C:integral component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0045121--C:membrane raft
GO:0032809--C:neuronal cell body membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0005388--F:calcium-transporting ATPase activity
GO:0046872--F:metal ion binding
GO:0030165--F:PDZ domain binding
GO:0007568--P:aging
GO:0007420--P:brain development
GO:1901660--P:calcium ion export
GO:0006816--P:calcium ion transport
GO:0098655--P:cation transmembrane transport
GO:0006874--P:cellular calcium ion homeostasis
GO:0071386--P:cellular response to corticosterone stimulus
GO:0071305--P:cellular response to vitamin D
GO:0003407--P:neural retina development
GO:0009409--P:response to cold