dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052374
Uniprot Accession G3XA57; RFIP2_MOUSE; B9EID4; Q5HZI0;
Genbank Protein ID NP_001028344.2; NP_001157839.1;
Genbank Nucleotide ID NM_001033172.3; NM_001164367.1;
Protein Name Rab11 family-interacting protein 2
Protein Synonyms/Alias
Gene Name Rab11fip2
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Phosphorylation Sites
 dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
148QFMRNNMTASMFDLSPhosphoPep 2.019060867
150MRNNMTASMFDLSMKPHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated21081558; 19060867; 22135298; 18846507; 19366988; 21743459;
162SMKDKTRSPFAKLKDPhosphoSitePlus22135298
184DGVFSDTSSAIVPSTcurated25338131
185GVFSDTSSAIVPSTHcurated25338131
224LGPQRLSSAHSMSDLcurated25338131
227QRLSSAHSMSDLTGSPHOSIDA;PhosphoSitePlus;curated21081558; 22135298; 26160508; 25338131
237DLTGSHLSSEKLKSScurated25338131
267GVVPESGSLKSPHRRcurated25338131
270PESGSLKSPHRRTLSPhosphoSitePlus;curated22135298; 25338131
277SPHRRTLSFDTSKLNPhosphoSitePlus;curated22135298; 25521595; 25338131
288SKLNQPGSIVDEGEHcurated25338131
317SLPQKFATLPRKKNPPhosphoSitePlus22135298
382LNNGGSDSPCDLKSPPhosphoSitePlus;curated22135298; 25338131
388DSPCDLKSPSAFSENPhosphoSitePlus;curated22135298; 25338131
428SSFHVNPTSSEDLRKcurated25338131
429SFHVNPTSSEDLRKIcurated25338131
Sequence
(Fasta)		MMLSEQAQKW FPTHVQVTVL QAKDLKPKGK SGTNDTYTII QLGKEKYSTS VAEKTLEPVW 60
KEEASFELPG LLMQGSPEKY ILFLIVMHRS LVGLDKFLGQ VAINLNDIFE DKQRRKTEWF 120
RLESKQGKRI KNRGEIKVNI QFMRNNMTAS MFDLSMKDKT RSPFAKLKDK MKGRKSDGVF 180
SDTSSAIVPS THMPDANPEF SSGEMQMKSK PKKPFLLGPQ RLSSAHSMSD LTGSHLSSEK 240
LKSSTVGPTH LLSRQIDSFG VVPESGSLKS PHRRTLSFDT SKLNQPGSIV DEGEHSFGRQ 300
SDPFTNVTAS LPQKFATLPR KKNPFEESSE PWDSSMNLFS KPIEVRKESK REKREKVSLF 360
ERVTGKRDSR RPDKLNNGGS DSPCDLKSPS AFSENRQDYF EYESTNPFTA KFRASTIMPS 420
SSFHVNPTSS EDLRKIPDNN PFDATAGYRS LTYEEVLQEL VKHKELLRRK DTHIRELEDY 480
IDNLLVRVME ETPSILRVPY EPSRKAGKFT NS 513
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR000008--C2_dom
IPR019018--Rab-bd_FIP-RBD
PROSITE

PS50004--C2
PS51511--FIP_RBD
Pfam

PF00168--C2
PF09457--RBD-FIP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0055038--C:recycling endosome membrane
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0017137--F:Rab GTPase binding
GO:0030010--P:establishment of cell polarity
GO:0035773--P:insulin secretion involved in cellular response to glucose stimulus
GO:0045055--P:regulated secretory pathway