dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052335
Uniprot Accession G3X939; SL9A3_MOUSE; Q8BZU0;
Genbank Protein ID NP_001074529.1; XP_006517085.1;
Genbank Nucleotide ID NM_001081060.1; XM_006517022.2;
Protein Name Sodium/hydrogen exchanger 3
Protein Synonyms/Alias
Gene Name Slc9a3
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)		 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
550AEGERRGSLAFIRSPPhosphoSitePlus;curated22135298; 22817900; 21183079
578RPSTVEASVSYFLREcurated25338131
580STVEASVSYFLRENVcurated25338131
588YFLRENVSAVCLDMQPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
603SLEQRRRSIRDTEDMPhosphoSitePlus;curated22135298; 22817900; 21183079
789ARVQIPNSPSNFRRLPhosphoSitePlus;curated22135298; 22817900; 21183079
791VQIPNSPSNFRRLTPPhosphoSitePlus;curated22135298; 22817900; 21183079
802RLTPFRLSNKSVDSFPhosphoSitePlus;curated22135298; 22817900; 21183079
805PFRLSNKSVDSFLQAPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
808LSNKSVDSFLQADGHPhosphoSitePlus;UniProt;curated22135298; 21183079; 22817900
Sequence
(Fasta)		MWHRALGPGW KLLLALALTS LQGARGAEEE PSSDGSFQVV TFKWHHVQDP YIIALWILVA 60
SLAKIVFHLS HKVTSIVPES ALLIVLGLVL GGIVWAADHI ASFTLTPTLF FFYLLPPIVL 120
DAGYFMPNRL FFGNLGTILL YAVIGTIWNA ATTGLSLYGV FLSGLMGELK IGLLDFLLFG 180
SLIAAVDPVA VLAVFEEVHV NEVLFIIVFG ESLLNDAVTV VLYNVFESFV TLGGDAVTGV 240
DCVKGIVSFF VVSLGGTLVG VIFAFLLSLV TRFTKHVRII EPGFVFVISY LSYLTSEMLS 300
LSSILAITFC GICCQKYVKA NISEQSATTV RYTMKMLASG AETIIFMFLG ISAVNPDIWT 360
WNTAFVLLTL VFISVYRAIG VVLQTWILNR YRMVQLETID QVVMSYGGLR GAVAYALVVL 420
LDEKKVKEKN LFVSTTLIVV FFTVIFQGLT IKPLVQWLKV KRSEHREPKL NEKLHGRAFD 480
HILSAIEDIS GQIGHNYLRD KWSNFDRKFL SKVLMRRSAQ KSRDRILNVF HELNLKDAIS 540
YVAEGERRGS LAFIRSPSTD NMVNVDFNTP RPSTVEASVS YFLRENVSAV CLDMQSLEQR 600
RRSIRDTEDM VTHHTLQQYL YKPRQEYKHL YSRHELTPNE DEKQDKEIFH RTMRKRLESF 660
KSAKLGINQN KKAAKLYKRE RAQKRRNSSI PNGKLPMENL AHNYTIKEKD LELSEHEEAT 720
NYEEISGGIE FLASVTQDVA SDSGAGIDNP VFSPDEDLDP SILSRVPPWL SPGETVVPSQ 780
RARVQIPNSP SNFRRLTPFR LSNKSVDSFL QADGHEEQLQ PAAPESTHM
Keyword

KW-0050--Antiport
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0915--Sodium
KW-0739--Sodium transport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR006153--Cation/H_exchanger
IPR018422--Cation/H_exchanger_CPA1
IPR018410--Na/H_exchanger_3/5
IPR004709--NaH_exchanger
IPR011256--Reg_factor_effector_dom
PROSITE
Pfam

PF00999--Na_H_Exchanger
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0031526--C:brush border membrane
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0031988--C:membrane-bounded vesicle
GO:0005886--C:plasma membrane
GO:0030165--F:PDZ domain binding
GO:0015385--F:sodium:proton antiporter activity
GO:0007623--P:circadian rhythm
GO:0006898--P:receptor-mediated endocytosis
GO:0006885--P:regulation of pH
GO:0002028--P:regulation of sodium ion transport
GO:0051384--P:response to glucocorticoid
GO:0035725--P:sodium ion transmembrane transport
GO:0006814--P:sodium ion transport