dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0052332 |
| Uniprot Accession | G3X912; SPRTN_MOUSE; B2RY42; |
| Genbank Protein ID | NP_001104611.1; |
| Genbank Nucleotide ID | NM_001111141.1; |
| Protein Name | SprT-like domain-containing protein Spartan |
| Protein Synonyms/Alias | Protein with SprT-like domain at the N terminus;Spartan; |
| Gene Name | Sprtn |
| Gene Synonyms/Alias | Gm505; |
| Organism | Mus musculus(Mouse) |
| NCBI Taxa ID | 10090 |
| Functional Description (View all) |
Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MDEDLVVALR LQEEWDVQMA RRAAAAREPV SLVDASWELV DPTPDLQALF LQFNDRFFWG 60 QLEAVEVKWS VRMTLCAGIC TYEGRGGMCS IRLSEPLLKL RPRKDLVETL LHEMIHAYLF 120 VTNNDKDREG HGPEFCKHMH RINQLTGANI TVYHTFHDEV DEYRRHWWRC NGPCQHRQPY 180 YGYVKRATNR APSVHDYWWA DHQKTCGGTY IKIKEPENYS KKGRGKTKAD KQPASAVENK 240 DKLCRGEAQL LIPFSGKGYV LGDASTCPSA GKLNTSYMVN EAKGLSSQDH SVSGLRLNSN 300 AEVKCEQNCL PKKPHLVSPL PTASHQSVLS SYFPRVSVAN QKAFRNVNGS PVKNGTTGDG 360 TKRPASGGSQ RKVPPSRASL RNTSKVTAPA SATVTSAAGT SATISREESG SEDQFLNKRP 420 RLEDRTALDT IKEQTQSGGD LRSSSQPTAA SAPQSLSSQR RLVNCPVCQG VVVESQINEH 480 LDRCLEGNKT NLRPRRV 498 |
| Keyword | KW-0007--Acetylation |
| Interpro | IPR006640--SprT-like_domain |
| PROSITE | PS00142--ZINC_PROTEASE |
| Pfam | PF10263--SprT-like |
| Gene Ontology | GO:0005694--C:chromosome |