dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052309
Uniprot Accession G3V9R8; HNRPC_RAT; D4ACR0; Q4V8K6;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Heterogeneous nuclear ribonucleoprotein C
Protein Synonyms/Alias
Gene Name Hnrnpc
Gene Synonyms/Alias Hnrpc;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
3-----MASNVTNKTDcurated23984901
9ASNVTNKTDPRSMNScurated23984901
25VFIGNLNTLVVKKSDcurated23984901
149PSKRQRVSGNTSRRGPhosphoSitePlus;curated22135298; 23712012
214QSKQADLSFSSPVEMPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457
216KQADLSFSSPVEMKNPhosphoSitePlus;curated22135298; 23712012; 21630457
217QADLSFSSPVEMKNEPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457; 23589303
226VEMKNEKSEEEQSSAPhosphoSitePlus;UniProt;curated22135298; 22673903; 22817900; 21630457
231EKSEEEQSSASVKKDPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457
232KSEEEQSSASVKKDEPhosphoSitePlus;SysPTM 2.0;curated22135298; 16641100; 19366988; 23712012; 21630457
234EEEQSSASVKKDETNPhosphoSitePlus;SysPTM 2.0;UniProt;curated22135298; 16641100; 19366988; 23712012; 21630457; 23984901
246ETNVKMESEAGADDSPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457
253SEAGADDSAEEGDLLPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457; 22276854
291EGEDDRDSANGEDDSPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457; 22276854
Sequence
(Fasta)		MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE 60
RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY 120
DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS SKSVKGDDLQ 180
AIKKELTQIK QKVDSLLESL EKIEKEQSKQ ADLSFSSPVE MKNEKSEEEQ SSASVKKDET 240
NVKMESEAGA DDSAEEGDLL DDDDNEDRGD DQLELKDDEK EPEEGEDDRD SANGEDDS 299
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0687--Ribonucleoprotein
KW-0694--RNA-binding
KW-0747--Spliceosome
KW-0832--Ubl conjugation
Interpro

IPR017347--hnRNP_C
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50102--RRM
Pfam

PF00076--RRM_1
Gene Ontology

GO:1990826--C:nucleoplasmic periphery of the nuclear pore complex
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:1990827--F:deaminase binding
GO:0004857--F:enzyme inhibitor activity
GO:0003729--F:mRNA binding
GO:1990247--F:N6-methyladenosine-containing RNA binding
GO:0000166--F:nucleotide binding
GO:0019904--F:protein domain specific binding
GO:0043021--F:ribonucleoprotein complex binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0043086--P:negative regulation of catalytic activity
GO:0090367--P:negative regulation of mRNA modification