| Tag |
Content |
| dbPAF ID |
dbPAF-0052295 |
| Uniprot Accession |
G3V9H8; RET_RAT; Q9EPA1; Q9EPC3;
|
| Genbank Protein ID |
NP_036775.2;
|
| Genbank Nucleotide ID |
NM_012643.2;
|
| Protein Name |
Proto-oncogene tyrosine-protein kinase receptor Ret |
| Protein Synonyms/Alias |
|
| Gene Name |
Ret |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration (By similarity).Functional Description
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MAKARSGAAG LGLKLFLLLP LLGEAPLGLY FSRDAYWERL YVDQPAGTPL LYVHALRDAP 60
GEVPSFRLGQ YLYGVYRTRL HENDWIHIDS GTGLLYLNQS LDHSSWEQLS IRNGGFPLLT 120
VFLQVFLGST AQREGECHWP GCARVYFSFI NDTFPNCSSF KARDLCTPET GVSFRIRENR 180
PPGTFYQFRM LPVQFLCPNI SVKYKLLEGD GLPFRCDPDC LEVSTRWALD RELQEKYVLE 240
AECAVAGPGA NKEKVAVSFP VTVYDEDDSP PTFSGGVGTA SAVVEFKRKE GTVVATLQVF 300
DADVVPASGE LVRRYTSTLL SGDSWAQQTF RVEHTPNETL VQSNNNSVRA TMHNYKLVLN 360
RSLSISESRV LQLVVLVNDS DFQGPGSGVL FLHFNVSVLP VTLNLPMAYS FPVNRRARRY 420
AQIGKVCVEN CQEFSGVSIQ YKLQPSSTNC SALGVVTSTE DTSGTLYVND TEALRRPECT 480
ELQYTVVATD RQTRRQTQAS LVVTVEGTYI AEEVGCPKSC AVNKRRPECE ECGGLGSPTG 540
RCEWRQGDGK GITRNFSTCS PSTRTCPDGH CDALESRDIN ICPQDCLRGP IVGGHERGER 600
QGIKAGYGIC NCFPDEKKCF CEPEDSQGPL CDELCRTVIT AAVLFSFIIS VLLSTFCIHR 660
YHKHAHKPPI ASAEMTFCRP AQGFPISYSS SGTRRPSLDS MENQVSVDSF KIPEDPKWEF 720
PRKNLVLGKT LGEGEFGKVV KATAFRLKGR AGYTTVAVKM LKENASQSEL RDLLSEFNLL 780
KQVNHPHVIK LYGACSQDGP LLLIVEYAKY GSLRGFLRDS RKIGPAYVSS GGSRNSSSLD 840
HPDERVLTMG DLISFAWQIS RGMQYLAEMK LVHRDLAARN ILVAEGRKMK ISDFGLSRDV 900
YEEDSYVKKS KGRIPVKWMA IESLFDHIYT TQSDVWSFGV LLWEIVTLGG NPYPGIPPER 960
LFNLLKTGHR MERPDNCSEE MYRLMLQCWK QEPDKRPVFA DISKDLEKMM VKSRDYLDLA 1020
ASTPSDSLLY DDGLSEEETP LVDCNSAPLP RSLPSTWIEN KLYGMSDPNW PGESPVPLTR 1080
ADGTSTGFPR YANDSVYANW MVSPSAAKLM DTFDS
1116Fasta Sequence
>G3V9H8|Ret|Rattus norvegicus(Rat)
MAKARSGAAGLGLKLFLLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAPGEVPSFRLGQYLYGVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQLSIRNGGFPLLTVFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENRPPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLEAECAVAGPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDRQTRRQTQASLVVTVEGTYIAEEVGCPKSCAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTRADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0106--Calcium
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0829--Tyrosine-protein kinase
|
| Interpro |
IPR002126--Cadherin
IPR015919--Cadherin-like
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR016249--Tyr_kinase_Ret_rcpt
|
| PROSITE |
PS50268--CADHERIN_2
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
|
| Pfam |
PF00028--Cadherin
PF07714--Pkinase_Tyr
|
| Gene Ontology |
GO:0030424--C:axon
GO:0030425--C:dendrite
GO:0005769--C:early endosome
GO:0010008--C:endosome membrane
GO:0005887--C:integral component of plasma membrane
GO:0045121--C:membrane raft
GO:0043025--C:neuronal cell body
GO:0043235--C:receptor complex
GO:0005524--F:ATP binding
GO:0005509--F:calcium ion binding
GO:0004714--F:transmembrane receptor protein tyrosine kinase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071300--P:cellular response to retinoic acid
GO:0001838--P:embryonic epithelial tube formation
GO:0048484--P:enteric nervous system development
GO:0007156--P:homophilic cell adhesion via plasma membrane adhesion molecules
GO:0060384--P:innervation
GO:0000165--P:MAPK cascade
GO:0033619--P:membrane protein proteolysis
GO:0001755--P:neural crest cell migration
GO:0007158--P:neuron cell-cell adhesion
GO:0042551--P:neuron maturation
GO:0061146--P:Peyer's patch morphogenesis
GO:0033630--P:positive regulation of cell adhesion mediated by integrin
GO:0030335--P:positive regulation of cell migration
GO:0045793--P:positive regulation of cell size
GO:2001241--P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0072300--P:positive regulation of metanephric glomerulus development
GO:0014042--P:positive regulation of neuron maturation
GO:0010976--P:positive regulation of neuron projection development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0050770--P:regulation of axonogenesis
GO:0042493--P:response to drug
GO:0048265--P:response to pain
GO:0060041--P:retina development in camera-type eye
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0035799--P:ureter maturation
GO:0001657--P:ureteric bud development
|
