dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0052280
Uniprot Accession G3V928; G3V928_RAT;
Genbank Protein ID NP_001123962.1;
Genbank Nucleotide ID NM_001130490.1;
Protein Name Protein Lrp1
Protein Synonyms/Alias
Gene Name Lrp1
Gene Synonyms/Alias rCG_59548;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
1558SHLCLINYNRTVSCAPhosphoSitePlus;curated22135298; 23712012
3142AYRTVLVSSGLREPRcurated23984901
4461GFQHQRMTNGAMNVEcurated23984901
4474VEIGNPTYKMYEGGEPhosphoSitePlus22135298
4508TNFTNPVYATLYMGGPhosphoSitePlus22135298
4521GGHGSRHSLASTDEKPhosphoSitePlus;SysPTM 2.0;curated22135298; 16396499; 19366988; 22817900; 21630457
4524GSRHSLASTDEKRELPhosphoSitePlus;curated22135298; 23712012; 21630457
4525SRHSLASTDEKRELLPhosphoSitePlus;curated22135298; 23712012; 21630457
Sequence
(Fasta)
MLTPPLLLLL PLLSALVAGA TMDAPKTCSP KQFACRDQIT CISKGWRCDG ERDCPDGSDE 60
APEICPQSKA QRCPPNEHSC LGTELCVPMS RLCNGIQDCM DGSDEGAHCR ELRVNCSRMG 120
CQHHCVPTPS GPTCYCNNSF QLQADGKTCK DFDECSVYGT CSQLCTNTDG SFTCGCVEGY 180
LLQPDNRSCK AKNEPVDRPP VLLIANSQNI LATYLSGAQV STITPTSTRQ TTAMDFSYAN 240
ETVCWVHVGD SAAQTQLKCA RMPSLKGFVD EHTINISLSL HHVEQMAIDW LTGNFYFVDD 300
IDDRIFVCNR NGDTCVTLLD LELYNPKGIA LDPAMGKVFF TDYGQIPKVE RCDMDGQNRT 360
KLVDSKIVFP HGITLDLVSR LVYWADAYLD YIEVVDYEGK GRQTIIQGIL IEHLYGLTVF 420
ENYLYATNSD NANTQQKTSV IRVNRFNSTE YQVVTRVDKG GALHIYHQRR QPRVRSHACE 480
NDQYGKPGGC SDICLLANSH KARTCRCRSG FSLGSDGKSC KKPEHELFLV YGKGRPGIIR 540
GMDMGAKVPD EHMIPIENLM NPRALDFHAE TGFIYFADTT SYLIGRQKID GTERETILKD 600
GIHNVEGVAV DWMGDNLYWT DDGPKKTISV ARLEKAAQTR KTLIEGKMTH PRAIVVDPLN 660
GWMYWTDWEE DPKDSRRGRL ERAWMDGSHR DIFVTSKTVL WPNGLSLDIP AGRLYWVDAF 720
YDRIETILLN GTDRKIVYEG PELNHAFGLC HHGNYLFWTE YRSGSVYRLE RGVAGAQPTV 780
TLLRSERPPI FEIRMYDAQQ QQVGTNKCRV NNGGCSSLCL ATPGSRQCAC AEDQVLDADG 840
VTCLANPSYV PPPQCQPGEF ACANNRCIQE RWKCDGDNDC LDNSDEAPAL CHQHTCPSDR 900
FKCENNRCIP NRWLCDGDND CGNSEDESNA TCSARTCPPN QFSCASGRCI PISWTCDLDD 960
DCGDRSDESA SCAYPTCFPL TQFTCNNGRC ININWRCDND NDCGDNSDEA GCSHSCSSTQ 1020
FKCNSGRCIP EHWTCDGDND CGDYSDETHA NCTNQATRPP GGCHSDEFQC RLDGLCIPLR 1080
WRCDGDTDCM DSSDEKGCEG VTHVCDPNVK FGCKDSARCI SKAWVCDGDS DCEDNSDEEN 1140
CEALACRPPS HPCANNTSVC LSPDKLCDGK DDCGDGSDEG ELCDQCSLNN GGCSHNCSVA 1200
PGEGIVCSCP LGMELGPDNH TCQIQSYCAK HLKCSQKCDQ NKFSVKCSCY EGWVLEPDGE 1260
SCRSLDPFKP FIIFSNRHEI RRIDLHKGDY SVLVPGLRNT IALDFHLSQS ALYWTDVVED 1320
KIYRGKLLDN GALTSFEVVI QYGLATPEGL AVDWIAGNIY WVESNLDQIE VAKLDGTLRT 1380
TLLAGDIEHP RAIALDPRDG ILFWTDWDAS LPRIEAASMS GAGRRTIHRE TGSGGWPNGL 1440
TVDYLEKRIL WIDARSDAIY SARYDGSGHM EVLRGHEFLS HPFAVTLYGG EVYWTDWRTN 1500
TLAKANKWTG HNVTVVQRTN TQPFDLQVYH PSRQPMAPNP CEANGGRGPC SHLCLINYNR 1560
TVSCACPHLM KLHNDNTTCY EFKKFLLYAR QMEIRGVDLD APYYNYIISF TVPDIDNVTV 1620
LDYDAREQRV YWSDVRTQAI KRAFINGTGV ETVVSADLPN AHGLAVDWVS RNLFWTSYDT 1680
NKKQINVARL DGSFKNAVVQ GLEQPHGLVV HPLRGKLYWT DGDNISMVNM DGSNRTLLFS 1740
GQKGPVGLAI DFPESKLYWI SSGNHTINRC NLDGSELEVI DTMRSQLGKA TALAIMGDKL 1800
WWADQVSEKM GTCNKADGSG SVVLRNSTTL VMHMKVYDES IQLEHEGTNP CSVNNGDCSQ 1860
LCLPTSETTR SCMCTAGYSL RSGQQACEGV GSFLLYSVHE GIRGIPLDPN DKSDALVPVS 1920
GTSLAVGIDF HAENDTIYWV DMGLSTISRA KRDQTWREDV VTNGIGRVEG IAVDWIAGNI 1980
YWTDQGFDVI EVARLNGSFR YVVISQGLDK PRAITVHPEK GYLFWTEWGH YPRIERSRLD 2040
GTERVVLVNV SISWPNGISV DYQGGKLYWC DARMDKIERI DLETGENREV VLSSNNMDMF 2100
SVSVFEDFIY WSDRTHANGS IKRGCKDNAT DSVPLRTGIG VQLKDIKVFN RDRQKGTNVC 2160
AVANGGCQQL CLYRGGGQRA CACAHGMLAE DGASCREYAG YLLYSERTIL KSIHLSDERN 2220
LNAPVQPFED PEHMKNVIAL AFDYRAGTSP GTPNRIFFSD IHFGNIQQIN DDGSGRTTIV 2280
ENVGSVEGLA YHRGWDTLYW TSYTTSTITR HTVDQTRPGA FERETVITMS GDDHPRAFVL 2340
DECQNLMFWT NWNELHPSIM RAALSGANVL TLIEKDIRTP NGLAIDHRAE KLYFSDATLD 2400
KIERCEYDGS HRYVILKSEP VHPFGLAVYG EHIFWTDWVR RAVQRANKYV GSDMKLLRVD 2460
IPQQPMGIIA VANDTNSCEL SPCRINNGGC QDLCLLTHQG HVNCSCRGGR ILQEDFTCRA 2520
MNSSCRAQDE FECANGECIS FSLTCDGVSH CKDKSDEKPS YCNSRRCKKT FRQCNNGRCV 2580
SNMLWCNGVD DCGDGSDEIP CNKTACGVGE FRCRDGSCIG NSSRCNQFVD CEDASDEMNC 2640
SATDCSSYFR LGVKGVLFQP CERTSLCYAP SWVCDGANDC GDYSDERDCP GVKRPRCPLN 2700
YFACPSGRCI PMSWTCDKED DCENGEDETH CNKFCSEAQF ECQNHRCISK QWLCDGSDDC 2760
GDGSDEAAHC EGKTCGPSSF SCPGTHVCVP ERWLCDGDKD CADGADESIS AGCLYNSTCD 2820
DREFMCQNRL CIPKHFVCDH DRDCADGSDE SPECEYPTCG PNEFRCANGR CLSSRQWECD 2880
GENDCHDHSD EAPKNPHCTS PEHKCNASSQ FLCSSGRCVA EALLCNGQDD CGDGSDERGC 2940
HVNECLSRKL SGCSQDCEDL KIGFKCRCRP GFRLKDDGRT CADVDECSTT FPCSQLCINT 3000
HGSYKCLCVE GYAPRGGDPH SCKAVTDEEP FLIFANRYYL RKLNLDGSNY TLLKQGLNNA 3060
VALDFDYRGQ MIYWTDVTTQ GSMIRRMHLN GSNVQVLHRT GLSNPDGLAV DWVGGNLYWC 3120
DKGRDTIEVS KLNGAYRTVL VSSGLREPRA LVVDVQNGYL YWTDWGDHSL IGRIGMDGSG 3180
RSIIVDTKIT WPNGLTVDYV TERIYWADAR EDYIEFASLD GSNRHVVLSQ DIPHIFALTL 3240
FEDYVYWTDW ETKSINRAHK TTGANKTLLI STLHRPMDLH VFHALRQPDV PNHPCKVNNG 3300
GCSNLCLLSP GGGHKCACPT NFYLGGDGRT CVSNCTASQF VCKNDKCIPF WWKCDTEDDC 3360
GDHSDEPPDC PEFKCRPGQF QCSTGICTNP AFICDGDNDC QDNSDEANCD IHVCLPSQFK 3420
CTNTNRCIPG IFRCNGQDNC GDGEDERDCP EVTCAPNQFQ CSITKRCIPR VWVCDRDNDC 3480
VDGSDEPANC TQMTCGVDEF RCKDSGRCIP ARWKCDGEDD CGDGSDEPKE ECDERTCEPY 3540
QFRCKNNRCV PGRWQCDYDN DCGDNSDEES CTPRPCSESE FSCANGRCIA GRWKCDGDHD 3600
CADGSDEKDC TPRCDMDQFQ CKSGHCIPLR WRCDADADCM DGSDEEACGT GVRTCPLDEF 3660
QCNNTLCKPL AWKCDGEDDC GDNSDENPEE CTRFQCPPNR PFRCKNDRVC LWIGRQCDGT 3720
DNCGDGTDEE DCEPPTAQNP HCKDKKEFLC RNQRCLSSSL RCNMFDDCGD GSDEEDCSID 3780
PKLTSCATNA SMCGDEARCV RTEKAAYCAC RPGFHTVPGQ PGCQDINECL RFGTCSQLCN 3840
NTKGGHLCSC ARNFMKTHNT CKAEGSEYQV LYIADDNEIR SLFPGHPHSA YEQAFQGDES 3900
VRIDAMDVHV KAGRVYWTNW HTGTISYRSL PPAAPPTTSN RHRRQIDRGV THLNISGLKM 3960
PRGIAIDWVA GNVYWTDSGR DVIEVAQMKG ENRKTLISGM IDEPHAIVVD PLRGTMYWSD 4020
WGNHPKIETA AMDGTLRETL VQDNIQWPTG LAVDYHNERL YWADAKLSVI GSIRLNGTDP 4080
IVAVDSKRGL SHPFSIDVFE DYIYGVTYIN NRVFKIHKFG HSPLINLTGG LSHASDVVLY 4140
HQHKQPEVTN PCDRKKCEWL CLLSPSGPVC TCPNGKRLDN GTCVPVPSPT PPPDAPRPGT 4200
CTLQCFNGGS CFLNARRQPK CRCQPRYTGD KCELDQCWEY CHNGGTCAAS PSGMPTCRCP 4260
TGFTGPRCTQ QVCAGYCANN STCTVNQGNQ PQCRCLPGFL GDRCQYRQCS GFCENFGTCQ 4320
MAADGSRQCR CTVYFEGTRC EVNKCSRCLQ GACVVNKQTG DVTCNCTDGR VAPSCLTCID 4380
HCSNGGSCTM NSKMMPECQC PPHMTGPRCE EQVVSQQQPG HMTSILIPLL LLLLLLLVAG 4440
VVFWYKRRVR GAKGFQHQRM TNGAMNVEIG NPTYKMYEGG EPDDVGGLLD ADFALDPDKP 4500
TNFTNPVYAT LYMGGHGSRH SLASTDEKRE LLGRGPEDEI GDPLA 4546
Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR026823--cEGF
IPR006150--Cys_repeat_1
IPR032485--DUF5050
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR009030--Growth_fac_rcpt_N_dom
IPR023415--LDLR_class-A_CS
IPR000033--LDLR_classB_rpt
IPR002172--LDrepeatLR_classA_rpt

PROSITE

PS00010--ASX_HYDROXYL
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS01209--LDLRA_1
PS50068--LDLRA_2
PS51120--LDLRB

Pfam

PF12662--cEGF
PF16472--DUF5050
PF00008--EGF
PF07645--EGF_CA
PF00057--Ldl_recept_a
PF00058--Ldl_recept_b

Gene Ontology

GO:0030136--C:clathrin-coated vesicle
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0005925--C:focal adhesion
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0043025--C:neuronal cell body
GO:0005730--C:nucleolus
GO:0043235--C:receptor complex
GO:0005509--F:calcium ion binding
GO:0044822--F:poly(A) RNA binding
GO:0002020--F:protease binding
GO:0007568--P:aging
GO:0008283--P:cell proliferation
GO:0021987--P:cerebral cortex development
GO:0042157--P:lipoprotein metabolic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0010977--P:negative regulation of neuron projection development
GO:0051222--P:positive regulation of protein transport
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway