Tag |
Content |
dbPAF ID |
dbPAF-0052279 |
Uniprot Accession |
G3V926; G3V926_RAT; |
Genbank Protein ID |
NP_001101058.1; |
Genbank Nucleotide ID |
NM_001107588.1; |
Protein Name |
Conserved helix-loop-helix ubiquitous kinase (Predicted) |
Protein Synonyms/Alias |
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Gene Name |
Chuk |
Gene Synonyms/Alias |
Chuk_predicted;rCG_57595; |
Organism |
Rattus norvegicus(Rat) |
NCBI Taxa ID |
10116 |
Functional Description (View all) |
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Phosphorylation Sites
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dbPAF PTMs: 2 Position | Peptides | Source | References ( PMIDs ) |
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176 | AKDVDQGSLCTSFVG | PhosphoSitePlus | 22135298 | 180 | DQGSLCTSFVGTLQY | PhosphoSitePlus;curated | 22135298; 22817900 |
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Sequence (Fasta) | MERPPGLRPG AGGPWEMRER LGTGGFGNVS LYQHRELDLK IAIKSCRLEL STKNRERWCH 60 EIQIMKKLNH ANVVKACDVP EELNFLINDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ 120 ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKIM HKIIDLGYAK DVDQGSLCTS 180 FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK 240 CIFACEEMTG EVRFSSHLPQ PNNLCSLIVE PMESWLQLML NWDPQQRGGP IDPPLKQPKC 300 FVLMDNILNL KIVHILNMTS AKIISFLLPY DESLHSLQSR IERETGINTG SQELLSETGI 360 SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDSKIQLPV 420 TQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTLI SASQQLKAKL 480 EFFRKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YSEVGVIGYL EDQIMSLHTE 540 IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPTDHSY SDSTEMVKII VHTVQSQDRV 600 LKELFGHLSK LLGCKQKIID LLPKVEVALS NIKEADNTVM FMQGKRQKEI WHLLKIACTQ 660 SSARSLVGSS LEGTVTPPVS AWLPPTLADR EHPLTCVVTP QDGETLAQMI EENLNCLGHL 720 STIIREANED QSSSMMSLDW SWLAE
746Fasta Sequence
>G3V926|Chuk|Rattus norvegicus(Rat) MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMTGEVRFSSHLPQPNNLCSLIVEPMESWLQLMLNWDPQQRGGPIDPPLKQPKCFVLMDNILNLKIVHILNMTSAKIISFLLPYDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPVTQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPTDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGTVTPPVSAWLPPTLADREHPLTCVVTPQDGETLAQMIEENLNCLGHLSTIIREANEDQSSSMMSLDWSWLAE
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Keyword |
KW-0067--ATP-binding KW-0181--Complete proteome KW-0418--Kinase KW-0547--Nucleotide-binding KW-1267--Proteomics identification KW-1185--Reference proteome KW-0723--Serine/threonine-protein kinase KW-0808--Transferase
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Interpro |
IPR022007--IKKbetaNEMObind IPR011009--Kinase-like_dom IPR000719--Prot_kinase_dom IPR017441--Protein_kinase_ATP_BS IPR008271--Ser/Thr_kinase_AS
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PROSITE |
PS00107--PROTEIN_KINASE_ATP PS50011--PROTEIN_KINASE_DOM PS00108--PROTEIN_KINASE_ST
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Pfam |
PF12179--IKKbetaNEMObind PF00069--Pkinase
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Gene Ontology |
GO:0005829--C:cytosol GO:0008385--C:IkappaB kinase complex GO:0043231--C:intracellular membrane-bounded organelle GO:0005654--C:nucleoplasm GO:0005524--F:ATP binding GO:0008384--F:IkappaB kinase activity GO:0046982--F:protein heterodimerization activity GO:0071356--P:cellular response to tumor necrosis factor GO:0007252--P:I-kappaB phosphorylation GO:0007595--P:lactation GO:0060749--P:mammary gland alveolus development GO:0033598--P:mammary gland epithelial cell proliferation GO:0002011--P:morphogenesis of an epithelial sheet GO:0042475--P:odontogenesis of dentin-containing tooth GO:0030316--P:osteoclast differentiation GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0010034--P:response to acetate GO:0043200--P:response to amino acid GO:0042493--P:response to drug GO:0033194--P:response to hydroperoxide GO:0032496--P:response to lipopolysaccharide GO:0035994--P:response to muscle stretch GO:0010033--P:response to organic substance GO:0009636--P:response to toxic substance GO:0007266--P:Rho protein signal transduction GO:0003009--P:skeletal muscle contraction GO:0051146--P:striated muscle cell differentiation
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