| Tag |
Content |
| dbPAF ID |
dbPAF-0052273 |
| Uniprot Accession |
G3V909; ATF6A_RAT; B5DF18;
|
| Genbank Protein ID |
NP_001100666.1;
|
| Genbank Nucleotide ID |
NM_001107196.1;
|
| Protein Name |
Cyclic AMP-dependent transcription factor ATF-6 alpha |
| Protein Synonyms/Alias |
|
| Gene Name |
Atf6 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (By similarity).Functional Description
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 556 | GDTFYVVSFRRDHLL | curated | 23800682 |
|
Sequence
(Fasta) | MESPFSPVLP HGPGEDWEST LFAELGYFTD TDDVQFDAAH ETYENNFDHL NFDLDLMPWE 60
SDIWSPSSHF CSDIKAEPQP LSPASSSCSV SSPRSTDSCS STQHVPEELD LLSSSQSPLS 120
LYGDSCHSPS SAEPLKEEKP VTGPGNKTEH GLTPKKKIQM SSKPSVQPKP LLLPAAPKTP 180
ANASVPAKTI IIQTLPALMP LAKQQSIISI QPAPTKGQTV LLSQPAVVQL QTPGVLPSAQ 240
PVLAVTGGAT QLPNHVVNVV PAPVVNSPVN GKLCVTKPVL QSSTRSTGSD IAVLRRQQRM 300
IKNRESACQS RKKKKEYMLG LEARLKAALS ENEQLKKENG SLKRQLDQVV SENQRLKVPS 360
PKRRAVCVMI VLAFIMLNYG PMSMLEQDSR RVKPSVSPAN QRRHLLEFSA KEVKDTSDGD 420
NQKNSYRYDH SVSNDKALMV LSEEPLLYIP PPPCQPLINT TESLRLNHEL RGWVHRHEVE 480
RTKSRRMTNS QQKTRILQGA LEQGSNSQLM AVQYTETTSI SRNSGSELQV YYASPGSYQG 540
FFDAIRRRGD TFYVVSFRRD HLLLPATTHN KTTRPKMSIV LPAININDNV INGQDYEVMM 600
QIDCQVMDTR ILHIKSSSVP PYLRDHQRNQ TSTFFGSPPT ATETTHVVST LPESVQ
657Fasta Sequence
>G3V909|Atf6|Rattus norvegicus(Rat)
MESPFSPVLPHGPGEDWESTLFAELGYFTDTDDVQFDAAHETYENNFDHLNFDLDLMPWESDIWSPSSHFCSDIKAEPQPLSPASSSCSVSSPRSTDSCSSTQHVPEELDLLSSSQSPLSLYGDSCHSPSSAEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPAAPKTPANASVPAKTIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPAVVQLQTPGVLPSAQPVLAVTGGATQLPNHVVNVVPAPVVNSPVNGKLCVTKPVLQSSTRSTGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDQVVSENQRLKVPSPKRRAVCVMIVLAFIMLNYGPMSMLEQDSRRVKPSVSPANQRRHLLEFSAKEVKDTSDGDNQKNSYRYDHSVSNDKALMVLSEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNSQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPGSYQGFFDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTATETTHVVSTLPESVQ
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0735--Signal-anchor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0834--Unfolded protein response
|
| Interpro |
IPR029801--ATF6A
IPR004827--bZIP
|
| PROSITE |
PS50217--BZIP
PS00036--BZIP_BASIC
|
| Pfam |
PF00170--bZIP_1
|
| Gene Ontology |
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0031625--F:ubiquitin protein ligase binding
GO:1990440--P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0006986--P:response to unfolded protein
GO:0006351--P:transcription, DNA-templated
|
