| Tag |
Content |
| dbPAF ID |
dbPAF-0052235 |
| Uniprot Accession |
G3V893; ZN335_RAT; Q8CIV9;
|
| Genbank Protein ID |
XP_008760786.1; XP_008773840.1;
|
| Genbank Nucleotide ID |
XM_008762564.1; XM_008775618.1;
|
| Protein Name |
Zinc finger protein 335 |
| Protein Synonyms/Alias |
NRC-interacting factor 1;NIF-1; |
| Gene Name |
Znf335 |
| Gene Synonyms/Alias |
Zfp335; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.Functional Description
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MEENEVESSS DAAPRPGQPE EPSESGLGVG TSEAVSADST DAATAPGLTE ADDSGVGQSS 60
DSGSRSVEEV SESISTEPLP QGYLPDSSSV SRGPVAEVPG GPPALVHSSA LPDPSMLVSD 120
CTASSSDLGS AIDKIIESTI GPDLIQSCIT VTSGEEGGAE TTQYLILQGP DDGAPMASSM 180
STSTLANSLA AIEALADGPT STSTCLEPAE QPPGEPSSLA QPPAPVVEEL DLQGLEAMME 240
VVVVQQFKCK MCQYRSSTKA TLLRHMRERH FRPALAVAAA AAGKRGRVRK WGTSTKTTEE 300
EGPEEEEEDD DIVDAGAIDD LEEDSDYNPA EDEPRGRQLR LQRPTPSTLR PRRRPGRPRK 360
LPRLETSDLH DGIGEPLVSS QSTQSPPELQ DLEAPSSSDL RALGKVGRGL VETGVSQSDA 420
ENAAPSCQDE ADVPPRRRGR PSRRFLGKKY RKYYYKSPKP LLRPYLCRIC GSRFLSHEDL 480
RFHVNSHEAG DPQLFKCLQC SYRSRRWSSL KEHMFNHVGS KPYKCDECSY TSVYRKDVIR 540
HAAVHSQDRK KRPDPTPKLS SFPCPVCGRV YPMQKRLTQH MKTHSTEKPH MCDKCGKSFK 600
KRYTFKMHLL THIQAVANRR FKCEFCEFVC EDKKALLNHQ LSHVSDKPFK CSFCPYRTFR 660
EDFLLSHVAV KHTGAKPFAC EYCHFSTRHK KNLRLHVRCR HANSFEEWGR RHPEEPPSRR 720
RPFFSLQQIE ELKQQHSAAP GPPLSSAGPE APQEPAPFQP PETPPLLCPD ALGGATIIYQ 780
QGAEESTAMA TQTALDLLLN MSAQRELGAT ALQVAVVKSE DVEAELTSTA RQPSSEDTTP 840
RVVTLHVAES GSSVAAESQL GPSDLQQIAL PPGPFSGASY SVITAPPVEG RASASGPPYR 900
EEPPGEAAQA VVVNDTLKEA GTHYIMAADG TQLHHIELTA DGSISFPSPD TLAPGTKWPL 960
LQCGGPPRDG PEVLSPTKTH HTGGSQGSST PPPATSHALG LLVPHSPPSA AASSTKKFSC 1020
KVCSEAFPSR AEMESHKRAH AGPAAFKCPD CPFSARQWPE VRAHMAQHSS LRPHQCNQCS 1080
FASKNKKDLR RHMLTHTNEK PFSCHVCGQR FNRNGHLKFH IQRLHSIDGR KTGTSTARAP 1140
AQTIILNSEE ETLATLHTAF QSNHGTLGTE RLQQALSQEH IIVAQEQTVA NQEEATYIQE 1200
ITADGQTVQH LVTSDNQVQY IISQDGVQHL LPQEYVVVPD GHHIQVQEGQ ITHIQYEQGT 1260
PFLQESQIQY VPVSPSQQLV TQAQLEAAAH SAVTAVADAA MAQAQGLFGT EEAVPEHIQQ 1320
LQHQGIEYDV ITLSDD
1337Fasta Sequence
>G3V893|Znf335|Rattus norvegicus(Rat)
MEENEVESSSDAAPRPGQPEEPSESGLGVGTSEAVSADSTDAATAPGLTEADDSGVGQSSDSGSRSVEEVSESISTEPLPQGYLPDSSSVSRGPVAEVPGGPPALVHSSALPDPSMLVSDCTASSSDLGSAIDKIIESTIGPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTLANSLAAIEALADGPTSTSTCLEPAEQPPGEPSSLAQPPAPVVEELDLQGLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPALAVAAAAAGKRGRVRKWGTSTKTTEEEGPEEEEEDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTLRPRRRPGRPRKLPRLETSDLHDGIGEPLVSSQSTQSPPELQDLEAPSSSDLRALGKVGRGLVETGVSQSDAENAAPSCQDEADVPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPLSSAGPEAPQEPAPFQPPETPPLLCPDALGGATIIYQQGAEESTAMATQTALDLLLNMSAQRELGATALQVAVVKSEDVEAELTSTARQPSSEDTTPRVVTLHVAESGSSVAAESQLGPSDLQQIALPPGPFSGASYSVITAPPVEGRASASGPPYREEPPGEAAQAVVVNDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGPEVLSPTKTHHTGGSQGSSTPPPATSHALGLLVPHSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQSNHGTLGTERLQQALSQEHIIVAQEQTVANQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPDGHHIQVQEGQITHIQYEQGTPFLQESQIQYVPVSPSQQLVTQAQLEAAAHSAVTAVADAAMAQAQGLFGTEEAVPEHIQQLQHQGIEYDVITLSDD
|
| Keyword |
KW-0010--Activator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
|
| PROSITE |
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
PF13912--zf-C2H2_6
|
| Gene Ontology |
GO:0035097--C:histone methyltransferase complex
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0007420--P:brain development
GO:0048854--P:brain morphogenesis
GO:0021895--P:cerebral cortex neuron differentiation
GO:0080182--P:histone H3-K4 trimethylation
GO:0001701--P:in utero embryonic development
GO:0048812--P:neuron projection morphogenesis
GO:2000327--P:positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
GO:0050671--P:positive regulation of lymphocyte proliferation
GO:0002052--P:positive regulation of neuroblast proliferation
GO:0040029--P:regulation of gene expression, epigenetic
GO:0051569--P:regulation of histone H3-K4 methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
|
