dbPAF - database of Phospho-sites in Animals and Fungi

Protein
Gene
PTMs
Sequence
Keyword
GO
TOP

dbPAF Protein Information

Tag

Content

dbPAF ID

dbPAF-0052224

Uniprot Accession

G3V824; G3V824_RAT;

Genbank Protein ID

NP_036888.2;

Genbank Nucleotide ID

NM_012756.2;

Protein Name

Insulin-like growth factor 2 receptor, isoform CRA_b

Protein Synonyms/Alias

Gene Name

Igf2r

Gene Synonyms/Alias

rCG_44907;

Organism

Rattus norvegicus(Rat)

NCBI Taxa ID

10116

Functional Description
(View all)

Phosphorylation Sites

dbPAF PTMs: 11

Position	Peptides	Source	References ( PMIDs )
477	AIDGKKRYDLSVLAR	PhosphoSitePlus	22135298
2334	LTNCCRRSSGVSYKY	PhosphoSitePlus	22135298
2335	TNCCRRSSGVSYKYS	PhosphoSitePlus	22135298
2350	KVSKEEETDENETEW	PhosphoSitePlus	22135298
2391	VKAEALTSLHGDDQD	curated	23712012; 21630457
2399	LHGDDQDSEDEVLTI	PhosphoSitePlus;curated	22135298; 22817900; 21630457; 22276854
2405	DSEDEVLTIPEVKVH	curated	23712012; 21630457
2462	RPGQRKPTTPAKLVS	PhosphoSitePlus;SysPTM 2.0;curated	22135298; 16641100; 19366988; 22817900
2463	PGQRKPTTPAKLVSF	PhosphoSitePlus;SysPTM 2.0	22135298; 16641100; 19366988
2469	TTPAKLVSFHDDSDE	PhosphoSitePlus;curated	22135298; 23712012; 21630457; 22276854
2474	LVSFHDDSDEDLLHI	PhosphoSitePlus;SysPTM 2.0;curated	22135298; 16641100; 19366988; 23712012; 21630457; 22276854

Sequence
(Fasta)

MRAVLPGPVP SGPRVALLLP LLLLLLVAAA GSAQAQAVDL DALCSYTWEA VDSKNNAVYK 60
INPCGHVDNP RCGPTSAVCM CDLKSENCRS VGDSLLRSSA KSLLEFNTTT GCQPSEHRIQ 120
TSITFLCGKT LGTPEFVTAT DCVHYFEWRT TAACKKDIFK ADKEVPCYVF DDKLQKHDLN 180
PLIKLNGGYL VDDSDADASL FINVCRDIDS LRDPSTQLRV CPAGTAACLL KGNQAFDVGR 240
PKEGLKLLSK DRLVLTYVKE EGEKPDFCNG HSPAVTVTFV CPSERREGTI PKLTAKSNCR 300
YEVEWITEYA CHRDYLESET CSLSSEQHDI AIDLSPLAQH EEGSPYVADG GEYRFFMNVC 360
GDTKVSLCNK EAAVCQEKKV DSTQVKIAGR HQNQTLRYSD GDLTLIYSGG DECSSGFQRM 420
SVINFECNKT AGQDGRGEPV FTGEVDCTYF FTWDTKYACV KEKEDLLCGA IDGKKRYDLS 480
VLARHSESEQ NWEAVDGSQA ESEKRNFFIN VCHRVLQAGK AKNCPEGAAV CAVDKSGSKN 540
LGKFVSSPTK EKGHIQLSYS DGDDCGNDKK ITTNITFVCK PGDLESAPVL RAAGPDGCSY 600
EFEWHTAAAC VLSQTEGENC TVLDAQAGFS FDLSLLTKKN GAYKVETDKY DFYINVCGPV 660
SVNLCQSNSG ACQVAKSGKS WNLGLSNTKL TYYDGMIQLS YRNGTLYNNE KHTPRSTLIT 720
FLCDRDAGVG FPEYQEEDNS TYNFRWYTSY ACPEEPLECM VTDPSMMEQY DLSSLVKFEG 780
GRGGNWYAME NSREHFTRRK YYLNVCRPLN PVPGCDRYAS ACQMKYENNE GSLAETVAIS 840
NLGVAKTGPV VEESGSLLLE YVNGSACTTS DGRLTTYSTR IHLVCGRGTM NSHPIFTFNW 900
ECVVSFLWNT EAACPIQTIT DSDQACSIRD PNSGFVFNLS PLNYSQGHMV LGIGKTFVFN 960
ICGTMPACGT VAGKPALGCE AETKIKDIKD LKPERPVGME KSLQLSAEGF LTLTYKGSSP 1020
SDRGTAFIIR FICNGDIYPG TPKFLHQDID SARGIRNTFF EFETALACIP SVVDCQVTDP 1080
AGNEYDLSAL SMVRKPWTAV DTSVHGKKRR FYLSVCTPLP YIPGCDGIAM GSCMVSEDKS 1140
QNLGVVQISP QATGNGSLSI LYVNGDRCGN QRYSTRIVFE CAQTSGSPMF QLLNNCEYVF 1200
VWRTVEACPV VREEGDNCQV KDPRHGNLYD LKPLALNDTI ISAGEYTYYF RVCGKLSLDV 1260
CSAHDGSKAV SSCQEKKGPQ GFQKVAGLLN QKLTFENGLL KMNYSGGDTC HKVYQRSTTI 1320
YFYCDRTTQK PVFLKETLDC SYLFEWRTQY ACPPFNVTEC SIQDEAGNSI DLSSLSRYSD 1380
NWEAVTRTGA TEHYLINVCK SLSPQAGTDP CPPEAAVCLL DGSKPVNLGR VRDGPQWTAG 1440
VTVLKYVDGD LCPDKIRKRS TIIRFTCSDS QVNSRPLFIS AVQDCEYTFS WPTPAACPVK 1500
SNIHDDCQVT NPSTGHLFDL SSLSGKAGIT ASYSEKGMVF MSICEENVNC SPGVGACFGQ 1560
TRISVGQASK RLSYKDQVLQ LVYENGSPCP SKSGLRYKSV ISFVCRPEAG PTNRPMLISL 1620
DKQSCTLFFS WHTPLACEQA TECTVRNGSS IIDLSPLIHR TGGYEAYDES EDDTSDTTPD 1680
FYINICQPLN PMHGVPCPAG ASVCKVPVDG PPIDIGRVTG PPIFNPVANE VYLNFESSTP 1740
CLADKYMNYT SLIAFHCRRG ISMGTPKLIR NNDCDFVFEW ETPIVCPDEV KTQGCAVTDE 1800
QLLYSFNLTS LSTSTFKVTR DAHTYSIGVC TTAADLDQEG CKDGGVCLLS GSKGASFGRL 1860
ASMQLDYRHQ DEAVILSYVN GDPCPPETED GEPCVFPFIY KGETYDECVL EGRAKLWCSK 1920
TANYDRDHEW GFCRPSNSHR MSAIIFTCDE NEDIGRPEVF SEDRGCEVTF EWKTKVVCPP 1980
KKMECKFVQK HKTYDLRLLS SLTGSWDFVH EGNSYFINLC QRVYKGPLDC SERASICKKS 2040
ATGQVQVLGL VHTQKLEVID ETVLVTYSKG HSCGGNKTAS SVIELTCAKT VGRPAFKRFD 2100
IDSCTYYFYW YSRAACAVRP QEVNMVNGTL TNPVTGKSFS LGEIYFKLFS ASGDMRSNGD 2160
NYLYEIQLSS ISSSSNPACS GANICQVKPN DQHFSRKVGT SDMTKYYVQD GDLDVVFTSS 2220
STCGKDKTKS VSSTIFFHCD PLLKDGVPEF SHETADCQYL FSWYTSAVCP LGVDFDDENA 2280
VPEYKGLSER SQAVGAVLSL LLVALTGCLL ALLLHKKERR ETVINKLTNC CRRSSGVSYK 2340
YSKVSKEEET DENETEWLME EIQVPAARLG KDGQENGHIT TKTVKAEALT SLHGDDQDSE 2400
DEVLTIPEVK VHTGRGAEVE SSQPLRNPQR KVLKEREGER MGLVRGEKAR RGKFRPGQRK 2460
PTTPAKLVSF HDDSDEDLLH I 2482

Fasta Sequence

>G3V824|Igf2r|Rattus norvegicus(Rat)
MRAVLPGPVPSGPRVALLLPLLLLLLVAAAGSAQAQAVDLDALCSYTWEAVDSKNNAVYKINPCGHVDNPRCGPTSAVCMCDLKSENCRSVGDSLLRSSAKSLLEFNTTTGCQPSEHRIQTSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKDIFKADKEVPCYVFDDKLQKHDLNPLIKLNGGYLVDDSDADASLFINVCRDIDSLRDPSTQLRVCPAGTAACLLKGNQAFDVGRPKEGLKLLSKDRLVLTYVKEEGEKPDFCNGHSPAVTVTFVCPSERREGTIPKLTAKSNCRYEVEWITEYACHRDYLESETCSLSSEQHDIAIDLSPLAQHEEGSPYVADGGEYRFFMNVCGDTKVSLCNKEAAVCQEKKVDSTQVKIAGRHQNQTLRYSDGDLTLIYSGGDECSSGFQRMSVINFECNKTAGQDGRGEPVFTGEVDCTYFFTWDTKYACVKEKEDLLCGAIDGKKRYDLSVLARHSESEQNWEAVDGSQAESEKRNFFINVCHRVLQAGKAKNCPEGAAVCAVDKSGSKNLGKFVSSPTKEKGHIQLSYSDGDDCGNDKKITTNITFVCKPGDLESAPVLRAAGPDGCSYEFEWHTAAACVLSQTEGENCTVLDAQAGFSFDLSLLTKKNGAYKVETDKYDFYINVCGPVSVNLCQSNSGACQVAKSGKSWNLGLSNTKLTYYDGMIQLSYRNGTLYNNEKHTPRSTLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECMVTDPSMMEQYDLSSLVKFEGGRGGNWYAMENSREHFTRRKYYLNVCRPLNPVPGCDRYASACQMKYENNEGSLAETVAISNLGVAKTGPVVEESGSLLLEYVNGSACTTSDGRLTTYSTRIHLVCGRGTMNSHPIFTFNWECVVSFLWNTEAACPIQTITDSDQACSIRDPNSGFVFNLSPLNYSQGHMVLGIGKTFVFNICGTMPACGTVAGKPALGCEAETKIKDIKDLKPERPVGMEKSLQLSAEGFLTLTYKGSSPSDRGTAFIIRFICNGDIYPGTPKFLHQDIDSARGIRNTFFEFETALACIPSVVDCQVTDPAGNEYDLSALSMVRKPWTAVDTSVHGKKRRFYLSVCTPLPYIPGCDGIAMGSCMVSEDKSQNLGVVQISPQATGNGSLSILYVNGDRCGNQRYSTRIVFECAQTSGSPMFQLLNNCEYVFVWRTVEACPVVREEGDNCQVKDPRHGNLYDLKPLALNDTIISAGEYTYYFRVCGKLSLDVCSAHDGSKAVSSCQEKKGPQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHKVYQRSTTIYFYCDRTTQKPVFLKETLDCSYLFEWRTQYACPPFNVTECSIQDEAGNSIDLSSLSRYSDNWEAVTRTGATEHYLINVCKSLSPQAGTDPCPPEAAVCLLDGSKPVNLGRVRDGPQWTAGVTVLKYVDGDLCPDKIRKRSTIIRFTCSDSQVNSRPLFISAVQDCEYTFSWPTPAACPVKSNIHDDCQVTNPSTGHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSPGVGACFGQTRISVGQASKRLSYKDQVLQLVYENGSPCPSKSGLRYKSVISFVCRPEAGPTNRPMLISLDKQSCTLFFSWHTPLACEQATECTVRNGSSIIDLSPLIHRTGGYEAYDESEDDTSDTTPDFYINICQPLNPMHGVPCPAGASVCKVPVDGPPIDIGRVTGPPIFNPVANEVYLNFESSTPCLADKYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPIVCPDEVKTQGCAVTDEQLLYSFNLTSLSTSTFKVTRDAHTYSIGVCTTAADLDQEGCKDGGVCLLSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDPCPPETEDGEPCVFPFIYKGETYDECVLEGRAKLWCSKTANYDRDHEWGFCRPSNSHRMSAIIFTCDENEDIGRPEVFSEDRGCEVTFEWKTKVVCPPKKMECKFVQKHKTYDLRLLSSLTGSWDFVHEGNSYFINLCQRVYKGPLDCSERASICKKSATGQVQVLGLVHTQKLEVIDETVLVTYSKGHSCGGNKTASSVIELTCAKTVGRPAFKRFDIDSCTYYFYWYSRAACAVRPQEVNMVNGTLTNPVTGKSFSLGEIYFKLFSASGDMRSNGDNYLYEIQLSSISSSSNPACSGANICQVKPNDQHFSRKVGTSDMTKYYVQDGDLDVVFTSSSTCGKDKTKSVSSTIFFHCDPLLKDGVPEFSHETADCQYLFSWYTSAVCPLGVDFDDENAVPEYKGLSERSQAVGAVLSLLLVALTGCLLALLLHKKERRETVINKLTNCCRRSSGVSYKYSKVSKEEETDENETEWLMEEIQVPAARLGKDGQENGHITTKTVKAEALTSLHGDDQDSEDEVLTIPEVKVHTGRGAEVESSQPLRNPQRKVLKEREGERMGLVRGEKARRGKFRPGQRKPTTPAKLVSFHDDSDEDLLHI

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0472--Membrane
KW-1267--Proteomics identification
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR000479--CIMR
IPR000562--FN_type2_col-bd
IPR013806--Kringle-like
IPR009011--Man6P_isomerase_rcpt-bd_dom

PROSITE

PS00023--FN2_1
PS51092--FN2_2

Pfam

PF00878--CIMR
PF00040--fn2

Gene Ontology

GO:0009986--C:cell surface
GO:0030118--C:clathrin coat
GO:0005769--C:early endosome
GO:0030139--C:endocytic vesicle
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0016021--C:integral component of membrane
GO:0005770--C:late endosome
GO:0005641--C:nuclear envelope lumen
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0030140--C:trans-Golgi network transport vesicle
GO:0019899--F:enzyme binding
GO:0001965--F:G-protein alpha-subunit binding
GO:0004930--F:G-protein coupled receptor activity
GO:0031995--F:insulin-like growth factor II binding
GO:0005010--F:insulin-like growth factor-activated receptor activity
GO:0005537--F:mannose binding
GO:0001972--F:retinoic acid binding
GO:0005215--F:transporter activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0048009--P:insulin-like growth factor receptor signaling pathway
GO:0001889--P:liver development
GO:0031100--P:organ regeneration
GO:0043065--P:positive regulation of apoptotic process
GO:0009791--P:post-embryonic development
GO:0015031--P:protein transport
GO:0042981--P:regulation of apoptotic process
GO:0032526--P:response to retinoic acid
GO:0007283--P:spermatogenesis