dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0052186
Uniprot Accession G3V783; G3V783_RAT;
Genbank Protein ID NP_001178794.1;
Genbank Nucleotide ID NM_001191865.1;
Protein Name Protein Ripk2
Protein Synonyms/Alias
Gene Name Ripk2
Gene Synonyms/Alias rCG_54865;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
174LSKWRMMSLSQSRSYcurated23984901
411AFCDRRASSCSLTVIPhosphoSitePlus22135298
412FCDRRASSCSLTVIRPhosphoSitePlus22135298
414DRRASSCSLTVIRPLPhosphoSitePlus22135298
Sequence
(Fasta)
MNGDAICSAL PHIPYHKLAD LHYLSRGASG TVSSARHADW RVRVAVKHLH IHTPLLDSER 60
NDILREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPEIAWPL 120
RFRILHEIAL GVNYLHNMNP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS 180
YKSAPEGGTI IYMPPENYEP GQKSRASVKH DIYSYAVIMW EVLSRKQPFE EVTNPLQIMY 240
SVSQGHRPNT SEENLPFDIP HRGLMISLIQ SGWAQNPDER PSFLKCLIEL EPVLRTFEDI 300
TFLEAVIQLK KSKIQSASST IHLCDKKMDL SLNIPASHPP QEESCGSSLL SRNAGSPGTS 360
RSLSAPQDKG FFHGGPQDCS SSKAYHCPGN HSWDGIISVS QEAAFCDRRA SSCSLTVIRP 420
LLVEKSSERP QPGIAQQWIQ SKREAIVSQM TEACLNQSLD ALLSRDLIMK EDYELISTKP 480
TRTAKVRQLL DTSDIQGEEF ARVIVQKLKD NKQMGLQPYP EVLLVSRTPS SNVLQNKTL 540
Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017322--Rcpt-int_Ser/Thr_kinase-2
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS50209--CARD
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00619--CARD
PF07714--Pkinase_Tyr

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0043234--C:protein complex
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0002250--P:adaptive immune response
GO:0071223--P:cellular response to lipoteichoic acid
GO:0071225--P:cellular response to muramyl dipeptide
GO:0071224--P:cellular response to peptidoglycan
GO:0050830--P:defense response to Gram-positive bacterium
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0070427--P:nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0046641--P:positive regulation of alpha-beta T cell proliferation
GO:0043065--P:positive regulation of apoptotic process
GO:0032722--P:positive regulation of chemokine production
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0033091--P:positive regulation of immature T cell proliferation
GO:0032729--P:positive regulation of interferon-gamma production
GO:0032743--P:positive regulation of interleukin-2 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0043330--P:response to exogenous dsRNA
GO:0070555--P:response to interleukin-1
GO:0070671--P:response to interleukin-12
GO:0070673--P:response to interleukin-18
GO:0042098--P:T cell proliferation
GO:0050852--P:T cell receptor signaling pathway
GO:0034134--P:toll-like receptor 2 signaling pathway
GO:0034142--P:toll-like receptor 4 signaling pathway