| Tag |
Content |
| dbPAF ID |
dbPAF-0052185 |
| Uniprot Accession |
G3V781; G3V781_RAT;
|
| Genbank Protein ID |
XP_006242594.1; XP_006242595.1; XP_006242596.1;
|
| Genbank Nucleotide ID |
XM_006242532.2; XM_006242533.1; XM_006242534.2;
|
| Protein Name |
Double-strand break repair protein MRE11A |
| Protein Synonyms/Alias |
|
| Gene Name |
Mre11a |
| Gene Synonyms/Alias |
rCG_31743; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
|
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 2 | ------MSPADPLDD | curated | 22276854 |
|
Sequence
(Fasta) | MSPADPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD 60
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN FGFSKFPWVN YQDGNLNISI 120
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 180
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 240
VIWGHEHECK IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP 300
LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPEK 360
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGKLIIK 420
PASEGTTLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 480
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA 540
FSADDLSFDI TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI 600
STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD DDSFPTSSRA 660
DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC PRRNRR
707Fasta Sequence
>G3V781|Mre11a|Rattus norvegicus(Rat)
MSPADPLDDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTLHSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRNEQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSLFNPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQKFVDRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRESRQRNTNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGRGRRGGRGQSTAPRGGSQRGRDTGLGISTRGRSSKATASTSRNMSIIDAFRSTRQQPSRNVATKNYSETIEVDESDDDDSFPTSSRADQRWSGTAPSKRMSQSQTAKGVDFESDEDDDDDPFMSGSCPRRNRR
|
| Keyword |
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0464--Manganese
KW-0469--Meiosis
KW-0540--Nuclease
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
|
| Interpro |
IPR004843--Calcineurin-like_PHP_apaH
IPR003701--DNA_repair_Mre11
IPR029052--Metallo-depent_PP-like
IPR007281--Mre11_DNA-bd
|
| PROSITE |
|
| Pfam |
PF00149--Metallophos
PF04152--Mre11_DNA_bind
|
| Gene Ontology |
GO:0000781--C:chromosome, telomeric region
GO:0000794--C:condensed nuclear chromosome
GO:0030870--C:Mre11 complex
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0035861--C:site of double-strand break
GO:0008408--F:3'-5' exonuclease activity
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0003677--F:DNA binding
GO:0004519--F:endonuclease activity
GO:0030145--F:manganese ion binding
GO:0000014--F:single-stranded DNA endodeoxyribonuclease activity
GO:0006284--P:base-excision repair
GO:0008283--P:cell proliferation
GO:0006302--P:double-strand break repair
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0007507--P:heart development
GO:0031573--P:intra-S DNA damage checkpoint
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0046597--P:negative regulation of viral entry into host cell
GO:0090305--P:nucleic acid phosphodiester bond hydrolysis
GO:0033674--P:positive regulation of kinase activity
GO:0031954--P:positive regulation of protein autophosphorylation
GO:0007062--P:sister chromatid cohesion
GO:0007129--P:synapsis
GO:0000723--P:telomere maintenance
|
