dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0052180 | ||||||||
| Uniprot Accession | G3V735; AMOL2_RAT; | ||||||||
| Genbank Protein ID | NP_113905.1; | ||||||||
| Genbank Nucleotide ID | NM_031717.1; | ||||||||
| Protein Name | Angiomotin-like protein 2 | ||||||||
| Protein Synonyms/Alias | |||||||||
| Gene Name | Amotl2 | ||||||||
| Gene Synonyms/Alias | |||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||
| NCBI Taxa ID | 10116 | ||||||||
| Functional Description (View all) |
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity). | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGAGGTGS PQASLEIGAP 60 EDSQVLQQAT RQEPQGQEHQ GGETHLAENR LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ 120 QAGSRLHGGD RDPRGASGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARVPSHMSS 180 SHSFPQLARS QQGPQPRGPP AEGPEPRGPP PQYPHAVMAQ ETAAVNDPRY RPRSSPHFQH 240 AEVRILQAQV PPVFLQQQQY QYLQQPQEHS PPLHPAALGH GPPSSFSPPA LEGPPGAQAT 300 SGSAHLAQME SVLRENARLQ RDNERLQREL ESTSEKASCI EKLENEIQRL SEAHESLMRT 360 SSKREALEKT MRNKMDSEMR RLQDFNRDLR ERLESANRHL ASKTQEAQAG SQDMVAKLLA 420 QSYEQQQEQE KLEREMALLR GAIEDQRRRA ELLEQALGNA QSRAARAEEE LRKKQAYVEK 480 VERLQQALGQ LQAACEKREQ LELRLRTRLE QELKALRAQQ RQTGTLTGGG GSHTGSTELS 540 ALRLSEQLRE KEEQILALEA DMTKWEQKYL EERAMRQFAM DAAATAAAQR DTTLIRHSPQ 600 PSPSSSFNEG LLAGNHRHQE MESRLKVLHA QILEKDAVIK VLQQRSRKDP GKATQGTLRP 660 AKSVPSIFAA AVGTQGWQGF STSERQTDAP ARQTVDRGPA EEPPATPPLP AHTKHGSRDG 720 STQTDGPADS TSACLASEPD SLLGCNGSQR TTSLDSIAAT RVQDLSDMVE ILI 774 |
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| Keyword | KW-0175--Coiled coil |
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| Interpro | |||||||||
| PROSITE | |||||||||
| Pfam | PF12240--Angiomotin_C |
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| Gene Ontology | GO:0055037--C:recycling endosome |