dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052163
Uniprot Accession G3V6S8; SRSF6_RAT; Q5PQM1;
Genbank Protein ID NP_001014207.2;
Genbank Nucleotide ID NM_001014185.2;
Protein Name Serine/arginine-rich splicing factor 6
Protein Synonyms/Alias Pre-mRNA-splicing factor SRP55;Splicing factor, arginine/serine-rich 6;
Gene Name Srsf6
Gene Synonyms/Alias Sfrs6;Srp55;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
45GFVEFEDSRDADDAVPhosphoSitePlus;UniProt22135298; 22673903
119LIVENLSSRCSWQDLcurated21630457
122ENLSSRCSWQDLKDFPhosphoSitePlus;curated22135298; 23984901
297KSKSRSRSQSRSHSPPhosphoSitePlus22135298
299KSRSRSQSRSHSPLPPhosphoSitePlus22135298
301RSRSQSRSHSPLPAPPhosphoSitePlus22135298
303RSQSRSHSPLPAPPSPhosphoSitePlus;UniProt;curated22135298; 22673903; 22817900; 21630457; 22276854
314APPSKARSMSPPPKRPhosphoSitePlus;curated22135298; 23712012; 21630457
316PSKARSMSPPPKRASPhosphoSitePlus;curated22135298; 23712012; 21630457
Sequence
(Fasta)		MPRVYIGRLS YNVREKDIQR FFSGYGRLLE IDLKNGYGFV EFEDSRDADD AVYELNSKEL 60
CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR 120
CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE 180
DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG 240
RKSRSKSKSK PKSDRGSHSH SRSRSKDKYG KSRSRSRSRS PKENGKGDIK SKSRSRSQSR 300
SHSPLPAPPS KARSMSPPPK RASRSRSRSR SRSRSSSRD
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0694--RNA-binding
Interpro

IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50102--RRM
Pfam

PF00076--RRM_1
Gene Ontology

GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0000166--F:nucleotide binding
GO:0044822--F:poly(A) RNA binding
GO:0036002--F:pre-mRNA binding
GO:0003723--F:RNA binding
GO:0000380--P:alternative mRNA splicing, via spliceosome
GO:0006376--P:mRNA splice site selection
GO:0060548--P:negative regulation of cell death
GO:0045617--P:negative regulation of keratinocyte differentiation
GO:0048025--P:negative regulation of mRNA splicing, via spliceosome
GO:0060501--P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0000381--P:regulation of alternative mRNA splicing, via spliceosome
GO:0010837--P:regulation of keratinocyte proliferation
GO:0061041--P:regulation of wound healing