dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0052150
Uniprot Accession G3V6K6; G3V6K6_RAT;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Epidermal growth factor receptor, isoform CRA_b
Protein Synonyms/Alias
Gene Name Egfr
Gene Synonyms/Alias rCG_23316;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
694RELVEPLTPSGEAPNPhosphoSitePlus;curated22135298; 21630457; 23984901
870LGAEEKEYHAEGGKVPhosphoSitePlus;curated22135298; 22817900
1017DVVDADEYLIPQQGFPhosphoSitePlus;curated22135298; 22817900
1068EDAFLQRYSSDPTSVPhosphoSitePlus;curated22135298; 22817900
1091TFLPVPEYINQSVPKPhosphoSitePlus;curated22135298; 22817900
1103VPKRPAGSVQNPVYHPhosphoSitePlus22135298
1109GSVQNPVYHNQPLHPPhosphoSitePlus;curated22135298; 22817900
1124APGRDLHYQNPHSNAPhosphoSitePlus22135298
1137NAVSNPEYLNTAQPTPhosphoSitePlus22135298
1171MSLDNPDYQQDFFPKPhosphoSitePlus;curated22135298; 22817900
1196PTAENAEYLRVAPPSPhosphoSitePlus;curated22135298; 22817900; 21630457
Sequence
(Fasta)
MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV 60
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 120
VLSNYGTNKT GLRELPMRNL QEILIGAVRF SNNPILCNME TIQWRDIVQD VFLSNMSMDV 180
QRHLTGCPKC DPSCPNGSCW GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC 240
TGPRESDCLV CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300
VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360
YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PENWTDLHAF 420
ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 480
FGTPNQKTKI MNNRAEKDCK ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN 540
ILEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM 600
GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG IVGGLLFIVV 660
VALGIGLFMR RRHIVRKRTL RRLLQERELV EPLTPSGEAP NQAHLRILKE TEFKKIKVLG 720
SGAFGTVYKG LWIPEGEKVK IPVAIKELRE ATSPKANKEI LDEAYVMASV DNPHVCRLLG 780
ICLTSTVQLI TQLMPYGCLL DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA 840
ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS 900
YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK CWMIDADSRP 960
KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR ALMEEEDMED VVDADEYLIP 1020
QQGFFNSPST SRTPLLSSLS ANSNSSAVAC INRNGSCRVK EDAFLQRYSS DPTSVLTEDN 1080
IDDTFLPVPE YINQSVPKRP AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT 1140
AQPTCLSSGF DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA 1200
PPSSEFIGA
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-0675--Receptor
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0829--Tyrosine-protein kinase

Interpro

IPR006211--Furin-like_Cys-rich_dom
IPR006212--Furin_repeat
IPR009030--Growth_fac_rcpt_N_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR000494--Rcpt_L-dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR016245--Tyr_kinase_EGF/ERB/XmrK_rcpt

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR

Pfam

PF00757--Furin-like
PF07714--Pkinase_Tyr
PF01030--Recep_L_domain

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0031901--C:early endosome membrane
GO:0030139--C:endocytic vesicle
GO:0005925--C:focal adhesion
GO:0016021--C:integral component of membrane
GO:0045121--C:membrane raft
GO:0097489--C:multivesicular body, internal vesicle lumen
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043235--C:receptor complex
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0005006--F:epidermal growth factor-activated receptor activity
GO:0030235--F:nitric-oxide synthase regulator activity
GO:0004716--F:receptor signaling protein tyrosine kinase activity
GO:0000902--P:cell morphogenesis
GO:0008283--P:cell proliferation
GO:0071230--P:cellular response to amino acid stimulus
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0071392--P:cellular response to estradiol stimulus
GO:0021795--P:cerebral cortex cell migration
GO:0048546--P:digestive tract morphogenesis
GO:0001892--P:embryonic placenta development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0001942--P:hair follicle development
GO:0007611--P:learning or memory
GO:0060571--P:morphogenesis of an epithelial fold
GO:0043066--P:negative regulation of apoptotic process
GO:0042177--P:negative regulation of protein catabolic process
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0030335--P:positive regulation of cell migration
GO:0031659--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0045739--P:positive regulation of DNA repair
GO:0045740--P:positive regulation of DNA replication
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0043406--P:positive regulation of MAP kinase activity
GO:0045429--P:positive regulation of nitric oxide biosynthetic process
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0046777--P:protein autophosphorylation
GO:0050999--P:regulation of nitric-oxide synthase activity
GO:0050730--P:regulation of peptidyl-tyrosine phosphorylation
GO:0070141--P:response to UV-A
GO:0007435--P:salivary gland morphogenesis
GO:0016337--P:single organismal cell-cell adhesion