Tag |
Content |
dbPAF ID |
dbPAF-0052150 |
Uniprot Accession |
G3V6K6; G3V6K6_RAT; |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Epidermal growth factor receptor, isoform CRA_b |
Protein Synonyms/Alias |
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Gene Name |
Egfr |
Gene Synonyms/Alias |
rCG_23316; |
Organism |
Rattus norvegicus(Rat) |
NCBI Taxa ID |
10116 |
Functional Description (View all) |
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Phosphorylation Sites
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dbPAF PTMs: 11 |
Sequence (Fasta) | MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV 60 VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 120 VLSNYGTNKT GLRELPMRNL QEILIGAVRF SNNPILCNME TIQWRDIVQD VFLSNMSMDV 180 QRHLTGCPKC DPSCPNGSCW GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC 240 TGPRESDCLV CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300 VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360 YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PENWTDLHAF 420 ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 480 FGTPNQKTKI MNNRAEKDCK ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN 540 ILEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM 600 GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG IVGGLLFIVV 660 VALGIGLFMR RRHIVRKRTL RRLLQERELV EPLTPSGEAP NQAHLRILKE TEFKKIKVLG 720 SGAFGTVYKG LWIPEGEKVK IPVAIKELRE ATSPKANKEI LDEAYVMASV DNPHVCRLLG 780 ICLTSTVQLI TQLMPYGCLL DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA 840 ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS 900 YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK CWMIDADSRP 960 KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR ALMEEEDMED VVDADEYLIP 1020 QQGFFNSPST SRTPLLSSLS ANSNSSAVAC INRNGSCRVK EDAFLQRYSS DPTSVLTEDN 1080 IDDTFLPVPE YINQSVPKRP AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT 1140 AQPTCLSSGF DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA 1200 PPSSEFIGA
Fasta Sequence
>G3V6K6|Egfr|Rattus norvegicus(Rat) MRPSGTARTKLLLLLAALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAVLSNYGTNKTGLRELPMRNLQEILIGAVRFSNNPILCNMETIQWRDIVQDVFLSNMSMDVQRHLTGCPKCDPSCPNGSCWGRGEENCQKLTKIICAQQCSRRCRGRSPSDCCHNQCAAGCTGPRESDCLVCHRFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGVSKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPENWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKATNHVCNPLCSSEGCWGPEPTDCVSCQNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGRGPDNCIKCAHYVDGPHCVKTCPSGIMGENNTLVWKFADANNVCHLCHANCTYGCAGPGLKGCQQPEGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMEEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSANSNSSAVACINRNGSCRVKEDAFLQRYSSDPTSVLTEDNIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVSNPEYLNTAQPTCLSSGFDSSALWIQKGSHQMSLDNPDYQQDFFPKEAKPNGIFKGPTAENAEYLRVAPPSSEFIGA
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Keyword |
KW-0067--ATP-binding KW-0181--Complete proteome KW-0418--Kinase KW-0472--Membrane KW-0547--Nucleotide-binding KW-1267--Proteomics identification KW-0675--Receptor KW-1185--Reference proteome KW-0732--Signal KW-0808--Transferase KW-0812--Transmembrane KW-1133--Transmembrane helix KW-0829--Tyrosine-protein kinase
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Interpro |
IPR006211--Furin-like_Cys-rich_dom IPR006212--Furin_repeat IPR009030--Growth_fac_rcpt_N_dom IPR011009--Kinase-like_dom IPR000719--Prot_kinase_dom IPR017441--Protein_kinase_ATP_BS IPR000494--Rcpt_L-dom IPR001245--Ser-Thr/Tyr_kinase_cat_dom IPR008266--Tyr_kinase_AS IPR020635--Tyr_kinase_cat_dom IPR016245--Tyr_kinase_EGF/ERB/XmrK_rcpt
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PROSITE |
PS00107--PROTEIN_KINASE_ATP PS50011--PROTEIN_KINASE_DOM PS00109--PROTEIN_KINASE_TYR
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Pfam |
PF00757--Furin-like PF07714--Pkinase_Tyr PF01030--Recep_L_domain
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Gene Ontology |
GO:0016323--C:basolateral plasma membrane GO:0009986--C:cell surface GO:0031901--C:early endosome membrane GO:0030139--C:endocytic vesicle GO:0005925--C:focal adhesion GO:0016021--C:integral component of membrane GO:0045121--C:membrane raft GO:0097489--C:multivesicular body, internal vesicle lumen GO:0005634--C:nucleus GO:0048471--C:perinuclear region of cytoplasm GO:0043235--C:receptor complex GO:0005524--F:ATP binding GO:0003682--F:chromatin binding GO:0005006--F:epidermal growth factor-activated receptor activity GO:0030235--F:nitric-oxide synthase regulator activity GO:0004716--F:receptor signaling protein tyrosine kinase activity GO:0000902--P:cell morphogenesis GO:0008283--P:cell proliferation GO:0071230--P:cellular response to amino acid stimulus GO:0071364--P:cellular response to epidermal growth factor stimulus GO:0071392--P:cellular response to estradiol stimulus GO:0021795--P:cerebral cortex cell migration GO:0048546--P:digestive tract morphogenesis GO:0001892--P:embryonic placenta development GO:0007173--P:epidermal growth factor receptor signaling pathway GO:0001942--P:hair follicle development GO:0007611--P:learning or memory GO:0060571--P:morphogenesis of an epithelial fold GO:0043066--P:negative regulation of apoptotic process GO:0042177--P:negative regulation of protein catabolic process GO:0035413--P:positive regulation of catenin import into nucleus GO:0030335--P:positive regulation of cell migration GO:0031659--P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0045739--P:positive regulation of DNA repair GO:0045740--P:positive regulation of DNA replication GO:0050679--P:positive regulation of epithelial cell proliferation GO:0070374--P:positive regulation of ERK1 and ERK2 cascade GO:0048146--P:positive regulation of fibroblast proliferation GO:0043406--P:positive regulation of MAP kinase activity GO:0045429--P:positive regulation of nitric oxide biosynthetic process GO:0051897--P:positive regulation of protein kinase B signaling GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0046777--P:protein autophosphorylation GO:0050999--P:regulation of nitric-oxide synthase activity GO:0050730--P:regulation of peptidyl-tyrosine phosphorylation GO:0070141--P:response to UV-A GO:0007435--P:salivary gland morphogenesis GO:0016337--P:single organismal cell-cell adhesion
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