| Tag |
Content |
| dbPAF ID |
dbPAF-0052148 |
| Uniprot Accession |
G3V6J1; G3V6J1_RAT;
|
| Genbank Protein ID |
|
| Genbank Nucleotide ID |
|
| Protein Name |
Thyrotropin receptor |
| Protein Synonyms/Alias |
|
| Gene Name |
LOC103692150 |
| Gene Synonyms/Alias |
LOC100360745;TSHR;rCG_20940; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).Functional Description
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MRPGSLLQLT LLLALPRSLW GRGCTSPPCE CHQEDDFRVT CKELHRIPSL PPSTQTLKLI 60
ETHLKTIPSL AFSSLPNISR IYLSIDATLQ RLEPHSFYNL SKMTHIEIRN TRSLTYIDPD 120
ALTELPLLKF LGIFNTGLRI FPDLTKIYST DVFFILEITD NPYMTSVPEN AFQGLCNETL 180
TLKLYNNGFT SIQGHAFNGT KLDAVYLNKN KYLTAIDKDA FGGVYSGPTL LDVSSTSVTA 240
LPSKGLEHLK ELIAKNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM 300
CNESSIRNLR QRKSVNVMRG PVYQEYEEGL GDNHVGYKQN SKFQEGPSNS HYYVFFEEQE 360
DEIIGFGQEL KNPQEETLQA FDSHYDYTVC GDNEDMVCTP KSDEFNPCED IMGYKFLRIV 420
VWFVSLMALL GNVFVLFVLL TSHYKLTVPR FLMCNLAFAD FCMGVYLLLI ASVDLYTHTE 480
YYNHAIDWQT GPGCNTAGFF TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHAYT 540
IMAGGWVSCF LLALLPMVGI SSYAKVSICL PMDTDTPLAL AYIALVLLLN VVAFVIVCSC 600
YVKIYITVRN PQYNPRDKDT KIAKRMAVLI FTDFMCMAPI SFYALSALMN KPLITVTNSK 660
ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGLCK HQAQAYQAQR VCPNNNTGIQ 720
IQKIPQDTRQ SLPNVQDTYE PLGSSHLTPK LQGRISEEYT QTAL
765Fasta Sequence
>G3V6J1|LOC103692150|Rattus norvegicus(Rat)
MRPGSLLQLTLLLALPRSLWGRGCTSPPCECHQEDDFRVTCKELHRIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDVFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTAIDKDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNVMRGPVYQEYEEGLGDNHVGYKQNSKFQEGPSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLMALLGNVFVLFVLLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHTEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKVSICLPMDTDTPLALAYIALVLLLNVVAFVIVCSCYVKIYITVRNPQYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQAQRVCPNNNTGIQIQKIPQDTRQSLPNVQDTYEPLGSSHLTPKLQGRISEEYTQTAL
|
| Keyword |
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0297--G-protein coupled receptor
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR000276--GPCR_Rhodpsn
IPR017452--GPCR_Rhodpsn_7TM
IPR002131--Gphrmn_rcpt_fam
IPR026906--LRR_5
IPR002274--TSH_rcpt
|
| PROSITE |
PS00237--G_PROTEIN_RECEP_F1_1
PS50262--G_PROTEIN_RECEP_F1_2
|
| Pfam |
PF00001--7tm_1
PF13306--LRR_5
|
| Gene Ontology |
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0004996--F:thyroid-stimulating hormone receptor activity
GO:0007189--P:adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0008344--P:adult locomotory behavior
GO:0030183--P:B cell differentiation
GO:0090103--P:cochlea morphogenesis
GO:0071542--P:dopaminergic neuron differentiation
GO:0060122--P:inner ear receptor stereocilium organization
GO:0040018--P:positive regulation of multicellular organism growth
GO:0040012--P:regulation of locomotion
|
