dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0052060
Uniprot Accession G3UWG2; G3UWG2_MOUSE;
Genbank Protein ID NP_001139358.1; NP_033410.2; XP_006523041.1; XP_006523043.1; XP_006523045.1; XP_011244414.1;
Genbank Nucleotide ID NM_001145886.1; NM_009384.3; XM_006522978.2; XM_006522980.2; XM_006522982.2; XM_011246112.1;
Protein Name T-cell lymphoma invasion and metastasis 1
Protein Synonyms/Alias
Gene Name Tiam1
Gene Synonyms/Alias mCG_129085;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
368TGRAFVGSDSGSSSTPHOSIDA21081558
372FVGSDSGSSSTGDAAPHOSIDA21081558
Sequence
(Fasta)		MGNAESQNVD HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKAIHR NSEVSTRSSS 60
TPSIPQSLAE NGLEPFSQEG ALDDFGDPIW VDRVDMGLRP VSYTDSSVTP SVDGSIVLTA 120
ASVQSMPDSE ESRLYGDDAT YLAEGGRRQC PYTSNGPTFM ETASFKKKRS KSADIWREDS 180
LEFSLSDLSQ EHLTSNEEIL GSAEEKDCEE ARGMETEASP RQLSTCQRAN SLGDLYAQKN 240
SGVKANGGPR NRFSSYCRNL VSDIPDLAKH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 300
ATNPQISLSK SMQGRRAKTT QDVNTGEGSE FADSGIEGAT TDTDLLSRRS NATNSSYSPP 360
TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES LEEAGSAHSD EQSSGTLSSP 420
GQSDILLTAA QGTVRKAGAL AVKNFLVHKK NKKVESATRR KWKHYWVSLK GCTLFFYETD 480
GRSGIDHNSV PKHAVWVENS IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT 540
AIHSACAAAV ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 600
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA MGRLGIFSVS 660
SFHALVAART GEIGVRRRTQ AMSRSASKRR SRFSSLWGLD TTSKKKQGRP TINQVFGEGT 720
DAVKRSLEGI FDDTVPDGKR EKEVVLPSVH QHNPDCDIWV HEYFTPSWFC LPNNQPALTV 780
VRPGDTARDT LELICKTHQL DHSAHYLRLK FLMENRVQFY IPQPEEDIYE LLYKEIEICP 840
KVTQNIHIEK SDAAADNYGF LLSSVDEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN 900
RAAGTLNSSM LKDFLSQPSL GLLVRTYPEP EGGVELLENP PHRVDGPVDL GESPLAFLTS 960
NPGHSLSSEQ GSSAETAPEE GEGPDLESSD ETDHSSKSTE QVAAFCRSLH EMSPSDSSPS 1020
PQDATSPQLA TTRQLSDADK LRKVICELLE TERTYVKDLN CLMERYLKPL QKETFLTQDE 1080
LDVLFGNLTE MVEFQVEFLK TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK 1140
LYSAFCASHT KVPKVLVKAK TDTAFKAFLD AQNPRQQHSS TLESYLIKPI QRVLKYPLLL 1200
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA EQTGEKKEVA 1260
DLSMGDLLLH TSVIWLNPPA SLGKWKKEPE LAAFVFKTAV VLVYKDGSKQ KKKLVGSHRL 1320
SIYEEWDPFR FRHMIPTEAL QVRALPSADA EANAVCEIVH VKSESEGRPE RVFHLCCSSP 1380
ESRKDFLKSV HSILRDKHRR QLLKTESLPS AQQYVPFGGK RLCALKGARP AMSRAVSAPS 1440
KSLGRRRRRL ARNRFTIDSD AISASSPEKE PQQPAGGGDT DRWVEEQFDL AQYEEQDDIK 1500
ETDILSDDDE FCESLKGASV DRDLQEQLQA ASISQRARGR RTLDSHASRM TQLKKQAALS 1560
GINGGLESAS EEVIWVRRED FAPSRKLNTE I 1592
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR001478--PDZ
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR003116--Raf-like_ras-bd
PROSITE

PS00741--DH_1
PS50010--DH_2
PS50106--PDZ
PS50003--PH_DOMAIN
PS50898--RBD
Pfam

PF00595--PDZ
PF00169--PH
PF02196--RBD
PF00621--RhoGEF
Gene Ontology

GO:0044291--C:cell-cell contact zone
GO:0005911--C:cell-cell junction
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005886--C:plasma membrane
GO:0046875--F:ephrin receptor binding
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0005543--F:phospholipid binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0005057--F:receptor signaling protein activity
GO:0016477--P:cell migration
GO:0007160--P:cell-matrix adhesion
GO:0048013--P:ephrin receptor signaling pathway
GO:0050772--P:positive regulation of axonogenesis
GO:0043547--P:positive regulation of GTPase activity
GO:0016601--P:Rac protein signal transduction
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction