dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0052022
Uniprot Accession F8WH10; F8WH10_MOUSE;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Vascular endothelial growth factor A
Protein Synonyms/Alias
Gene Name Vegfa
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
160QESGLPRSPSRRGSAPhosphoSitePlus22135298
Sequence
(Fasta)
LTDRQTDTAP SPSAHLLAGG LPTVDAAASR EEPKPAPGGG VEGVGARGIA RKLFVQLLGS 60
SRSVVAVVCA AGDKPIGAGR SASSGLEKPG PEKRGEEEKE EERGPQWALG SQEPSSWTGE 120
AAVCADSAPA ARAPQAPARA SVPEGRGARQ GAQESGLPRS PSRRGSASRA GPGRASETMN 180
FLLSWVHWTL ALLLYLHHAK WSQAAPTTEG EQKSHEVIKF MDVYQRSYCR PIETLVDIFQ 240
EYPDEIEYIF KPSCVPLMRC AGCCNDEALE CVPTSESNIT MQIMRIKPHQ SQHIGEMSFL 300
QHSRCECRPK KDRTKPENHC EPCSERRKHL FVQDPQTCKC SCKNTDSRCK ARQLELNERT 360
CRCDKPRR 369
Keyword

KW-0181--Complete proteome
KW-0339--Growth factor
KW-0497--Mitogen
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR029034--Cystine-knot_cytokine
IPR023581--PD_growth_factor_CS
IPR000072--PDGF/VEGF_dom
IPR027928--VEGF_C

PROSITE

PS00249--PDGF_1
PS50278--PDGF_2

Pfam

PF00341--PDGF
PF14554--VEGF_C

Gene Ontology

GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0016020--C:membrane
GO:0030141--C:secretory granule
GO:0042056--F:chemoattractant activity
GO:0005125--F:cytokine activity
GO:0050840--F:extracellular matrix binding
GO:0001968--F:fibronectin binding
GO:0008083--F:growth factor activity
GO:0008201--F:heparin binding
GO:0042802--F:identical protein binding
GO:0038191--F:neuropilin binding
GO:0005161--F:platelet-derived growth factor receptor binding
GO:0046982--F:protein heterodimerization activity
GO:0048018--F:receptor agonist activity
GO:0005102--F:receptor binding
GO:0043183--F:vascular endothelial growth factor receptor 1 binding
GO:0043184--F:vascular endothelial growth factor receptor 2 binding
GO:0005172--F:vascular endothelial growth factor receptor binding
GO:0032147--P:activation of protein kinase activity
GO:0001525--P:angiogenesis
GO:0048844--P:artery morphogenesis
GO:0002575--P:basophil chemotaxis
GO:0001568--P:blood vessel development
GO:0048514--P:blood vessel morphogenesis
GO:0048754--P:branching morphogenesis of an epithelial tube
GO:0048593--P:camera-type eye morphogenesis
GO:0048739--P:cardiac muscle fiber development
GO:0048469--P:cell maturation
GO:0016477--P:cell migration
GO:0002042--P:cell migration involved in sprouting angiogenesis
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0035924--P:cellular response to vascular endothelial growth factor stimulus
GO:0071542--P:dopaminergic neuron differentiation
GO:0035767--P:endothelial cell chemotaxis
GO:0043542--P:endothelial cell migration
GO:0030855--P:epithelial cell differentiation
GO:0042462--P:eye photoreceptor cell development
GO:0040007--P:growth
GO:0003007--P:heart morphogenesis
GO:0001701--P:in utero embryonic development
GO:0050930--P:induction of positive chemotaxis
GO:0001822--P:kidney development
GO:0007595--P:lactation
GO:0030324--P:lung development
GO:0060426--P:lung vasculature development
GO:0001946--P:lymphangiogenesis
GO:0030225--P:macrophage differentiation
GO:0060749--P:mammary gland alveolus development
GO:0007498--P:mesoderm development
GO:0030224--P:monocyte differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:0022408--P:negative regulation of cell-cell adhesion
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001541--P:ovarian follicle development
GO:0001569--P:patterning of blood vessels
GO:0050918--P:positive chemotaxis
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0045785--P:positive regulation of cell adhesion
GO:0051781--P:positive regulation of cell division
GO:0030335--P:positive regulation of cell migration
GO:0090050--P:positive regulation of cell migration involved in sprouting angiogenesis
GO:0008284--P:positive regulation of cell proliferation
GO:0038091--P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0051272--P:positive regulation of cellular component movement
GO:0032793--P:positive regulation of CREB transcription factor activity
GO:0038033--P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0010595--P:positive regulation of endothelial cell migration
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0051894--P:positive regulation of focal adhesion assembly
GO:0010628--P:positive regulation of gene expression
GO:1901727--P:positive regulation of histone deacetylase activity
GO:1901492--P:positive regulation of lymphangiogenesis
GO:0043406--P:positive regulation of MAP kinase activity
GO:0060754--P:positive regulation of mast cell chemotaxis
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0002052--P:positive regulation of neuroblast proliferation
GO:1900745--P:positive regulation of p38MAPK cascade
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:1900086--P:positive regulation of peptidyl-tyrosine autophosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0050927--P:positive regulation of positive chemotaxis
GO:0031954--P:positive regulation of protein autophosphorylation
GO:0031334--P:positive regulation of protein complex assembly
GO:0090037--P:positive regulation of protein kinase C signaling
GO:1903572--P:positive regulation of protein kinase D signaling
GO:1902966--P:positive regulation of protein localization to early endosome
GO:0001934--P:positive regulation of protein phosphorylation
GO:0002092--P:positive regulation of receptor internalization
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0061419--P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0030949--P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0043117--P:positive regulation of vascular permeability
GO:0031077--P:post-embryonic camera-type eye development
GO:0060319--P:primitive erythrocyte differentiation
GO:0008360--P:regulation of cell shape
GO:0030823--P:regulation of cGMP metabolic process
GO:0045601--P:regulation of endothelial cell differentiation
GO:1901532--P:regulation of hematopoietic progenitor cell differentiation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0001666--P:response to hypoxia
GO:0043129--P:surfactant homeostasis
GO:0035148--P:tube formation
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0038084--P:vascular endothelial growth factor signaling pathway
GO:0001944--P:vasculature development