Tag |
Content |
dbPAF ID |
dbPAF-0052022 |
Uniprot Accession |
F8WH10; F8WH10_MOUSE; |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Vascular endothelial growth factor A |
Protein Synonyms/Alias |
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Gene Name |
Vegfa |
Gene Synonyms/Alias |
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Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
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Phosphorylation Sites
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dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
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160 | QESGLPRSPSRRGSA | PhosphoSitePlus | 22135298 |
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Sequence (Fasta) | LTDRQTDTAP SPSAHLLAGG LPTVDAAASR EEPKPAPGGG VEGVGARGIA RKLFVQLLGS 60 SRSVVAVVCA AGDKPIGAGR SASSGLEKPG PEKRGEEEKE EERGPQWALG SQEPSSWTGE 120 AAVCADSAPA ARAPQAPARA SVPEGRGARQ GAQESGLPRS PSRRGSASRA GPGRASETMN 180 FLLSWVHWTL ALLLYLHHAK WSQAAPTTEG EQKSHEVIKF MDVYQRSYCR PIETLVDIFQ 240 EYPDEIEYIF KPSCVPLMRC AGCCNDEALE CVPTSESNIT MQIMRIKPHQ SQHIGEMSFL 300 QHSRCECRPK KDRTKPENHC EPCSERRKHL FVQDPQTCKC SCKNTDSRCK ARQLELNERT 360 CRCDKPRR
369Fasta Sequence
>F8WH10|Vegfa|Mus musculus(Mouse) LTDRQTDTAPSPSAHLLAGGLPTVDAAASREEPKPAPGGGVEGVGARGIARKLFVQLLGSSRSVVAVVCAAGDKPIGAGRSASSGLEKPGPEKRGEEEKEEERGPQWALGSQEPSSWTGEAAVCADSAPAARAPQAPARASVPEGRGARQGAQESGLPRSPSRRGSASRAGPGRASETMNFLLSWVHWTLALLLYLHHAKWSQAAPTTEGEQKSHEVIKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNITMQIMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPENHCEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
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Keyword |
KW-0181--Complete proteome KW-0339--Growth factor KW-0497--Mitogen KW-1267--Proteomics identification KW-1185--Reference proteome
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Interpro |
IPR029034--Cystine-knot_cytokine IPR023581--PD_growth_factor_CS IPR000072--PDGF/VEGF_dom IPR027928--VEGF_C
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PROSITE |
PS00249--PDGF_1 PS50278--PDGF_2
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Pfam |
PF00341--PDGF PF14554--VEGF_C
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Gene Ontology |
GO:0009986--C:cell surface GO:0005737--C:cytoplasm GO:0005576--C:extracellular region GO:0005615--C:extracellular space GO:0016020--C:membrane GO:0030141--C:secretory granule GO:0042056--F:chemoattractant activity GO:0005125--F:cytokine activity GO:0050840--F:extracellular matrix binding GO:0001968--F:fibronectin binding GO:0008083--F:growth factor activity GO:0008201--F:heparin binding GO:0042802--F:identical protein binding GO:0038191--F:neuropilin binding GO:0005161--F:platelet-derived growth factor receptor binding GO:0046982--F:protein heterodimerization activity GO:0048018--F:receptor agonist activity GO:0005102--F:receptor binding GO:0043183--F:vascular endothelial growth factor receptor 1 binding GO:0043184--F:vascular endothelial growth factor receptor 2 binding GO:0005172--F:vascular endothelial growth factor receptor binding GO:0032147--P:activation of protein kinase activity GO:0001525--P:angiogenesis GO:0048844--P:artery morphogenesis GO:0002575--P:basophil chemotaxis GO:0001568--P:blood vessel development GO:0048514--P:blood vessel morphogenesis GO:0048754--P:branching morphogenesis of an epithelial tube GO:0048593--P:camera-type eye morphogenesis GO:0048739--P:cardiac muscle fiber development GO:0048469--P:cell maturation GO:0016477--P:cell migration GO:0002042--P:cell migration involved in sprouting angiogenesis GO:0008283--P:cell proliferation GO:0071456--P:cellular response to hypoxia GO:0035924--P:cellular response to vascular endothelial growth factor stimulus GO:0071542--P:dopaminergic neuron differentiation GO:0035767--P:endothelial cell chemotaxis GO:0043542--P:endothelial cell migration GO:0030855--P:epithelial cell differentiation GO:0042462--P:eye photoreceptor cell development GO:0040007--P:growth GO:0003007--P:heart morphogenesis GO:0001701--P:in utero embryonic development GO:0050930--P:induction of positive chemotaxis GO:0001822--P:kidney development GO:0007595--P:lactation GO:0030324--P:lung development GO:0060426--P:lung vasculature development GO:0001946--P:lymphangiogenesis GO:0030225--P:macrophage differentiation GO:0060749--P:mammary gland alveolus development GO:0007498--P:mesoderm development GO:0030224--P:monocyte differentiation GO:0043066--P:negative regulation of apoptotic process GO:0022408--P:negative regulation of cell-cell adhesion GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0001541--P:ovarian follicle development GO:0001569--P:patterning of blood vessels GO:0050918--P:positive chemotaxis GO:0045766--P:positive regulation of angiogenesis GO:0043536--P:positive regulation of blood vessel endothelial cell migration GO:0045785--P:positive regulation of cell adhesion GO:0051781--P:positive regulation of cell division GO:0030335--P:positive regulation of cell migration GO:0090050--P:positive regulation of cell migration involved in sprouting angiogenesis GO:0008284--P:positive regulation of cell proliferation GO:0038091--P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0051272--P:positive regulation of cellular component movement GO:0032793--P:positive regulation of CREB transcription factor activity GO:0038033--P:positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0010595--P:positive regulation of endothelial cell migration GO:0001938--P:positive regulation of endothelial cell proliferation GO:0050679--P:positive regulation of epithelial cell proliferation GO:0070374--P:positive regulation of ERK1 and ERK2 cascade GO:0051894--P:positive regulation of focal adhesion assembly GO:0010628--P:positive regulation of gene expression GO:1901727--P:positive regulation of histone deacetylase activity GO:1901492--P:positive regulation of lymphangiogenesis GO:0043406--P:positive regulation of MAP kinase activity GO:0060754--P:positive regulation of mast cell chemotaxis GO:0002053--P:positive regulation of mesenchymal cell proliferation GO:0002052--P:positive regulation of neuroblast proliferation GO:1900745--P:positive regulation of p38MAPK cascade GO:0033138--P:positive regulation of peptidyl-serine phosphorylation GO:1900086--P:positive regulation of peptidyl-tyrosine autophosphorylation GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation GO:0050927--P:positive regulation of positive chemotaxis GO:0031954--P:positive regulation of protein autophosphorylation GO:0031334--P:positive regulation of protein complex assembly GO:0090037--P:positive regulation of protein kinase C signaling GO:1903572--P:positive regulation of protein kinase D signaling GO:1902966--P:positive regulation of protein localization to early endosome GO:0001934--P:positive regulation of protein phosphorylation GO:0002092--P:positive regulation of receptor internalization GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter GO:0061419--P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0030949--P:positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0043117--P:positive regulation of vascular permeability GO:0031077--P:post-embryonic camera-type eye development GO:0060319--P:primitive erythrocyte differentiation GO:0008360--P:regulation of cell shape GO:0030823--P:regulation of cGMP metabolic process GO:0045601--P:regulation of endothelial cell differentiation GO:1901532--P:regulation of hematopoietic progenitor cell differentiation GO:0006357--P:regulation of transcription from RNA polymerase II promoter GO:0001666--P:response to hypoxia GO:0043129--P:surfactant homeostasis GO:0035148--P:tube formation GO:0048010--P:vascular endothelial growth factor receptor signaling pathway GO:0038084--P:vascular endothelial growth factor signaling pathway GO:0001944--P:vasculature development
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