dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0051965
Uniprot Accession F8VQN6; F8VQN6_MOUSE;
Genbank Protein ID NP_081420.2;
Genbank Nucleotide ID NM_027144.2;
Protein Name Rho guanine nucleotide exchange factor 12
Protein Synonyms/Alias
Gene Name Arhgef12
Gene Synonyms/Alias
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
342EPQSLVGSPSTRGAPSysPTM 2.015345747; 19366988
Sequence
(Fasta)
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERSS SHDFDPTDSS SKKTKSSSEE 60
SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT 120
LVTHSNHLEV VKLIRSGSYV ALTVQGRPPG SPQIPLADSE VEPSVTGHMS PIMTSPHSPG 180
AAGNMERITS PVLVGEENNV VHNQKVEILR KMLQKEQERL QLLQEDYNRT ATQRLLKEIQ 240
EAKKHIPQLQ EQLSKATGSA QDGAVIAPSR PLGDALTLSE AEADPGDGLC RTDWSSGDAS 300
RPSSDSADSP KSSLRERSYL EEAPERSEGV QDAQEPQSLV GSPSTRGAPH IIGAEDDDFG 360
TEHEQINGQC SCFQSIELLK SRPAHLAVFL HHVVSQFDPA TLLCYLYSDL YKQTNSKETR 420
RVFLEFHQFF LDRSAHLKVP VPEEISVDLE KRRPELIPED LHRLYIQTMQ ERVHPEVQRH 480
LEDFRQKRSM GLTLAESELT KLDAERDKDR GTLEKERACA EQIVTKIEEV LMTAQAVEEE 540
RSSTMQYVIL MYMKYLGVKV KEPRNLEHKR GRIGFLPKIK QSMKKDREGE EKGKRRGFPS 600
ILGPPRRPSR HDNSAIGRAM EIQKSRHPKH LSTPSSVSPE PQDPAKLRQS GVANEGTDTG 660
YLPASSMSSA TSGTALSQEG GRENDTGTKQ VGEASAPGDC LDSTPRVPTT VFDFPPPLLD 720
QVQEEECEVE RVAEHGTPKP FRKFDSIAFG ESQSEDEQFE NDLETDPPNW QQLVSREVLL 780
GLKPSEIKRQ EVINELFYTE RAHVRTLKVL DQVFYQRVSR EGILSPSELR KIFSNLEDIL 840
QLHVGLNEQM KAVRKRNETS VIDHIGEDLL IWFSGPGEEK LKHAAATFCS NQPFALEMIK 900
SRQKKDSRFH TFVQDAESNP LCRRLQLKDI IPTQMQRLTK YPLLLDNIAK YTEWPPEREK 960
VKKAADHCRQ ILNYVNQAVR EAENKQRLED YQRRLDTSNL KLSEYPNVDE LRNLDLTKRK 1020
MIHEGPLVWK VNRDKSIDLY TLLLEDILVL LQKQDDRLVL RCHSKILAST ADSKHTFSPV 1080
IKLSTVLVRQ VATDNKALFV ISMSDNGAQI YELVAQTVSE KTVWQDLICR MAASVKEQST 1140
KPIPLPQPPP CEGDNDEEEP AKLKVEHHDL SVAGLQSPDR VLGLESPLIS SKPQSHSLNT 1200
PGKSAAEHLF VTATQFAKEQ HANGALKEGD GGYPVTIPGP HLPVSEERWA LDALRNLGLL 1260
KQLLVQQLGL TEKSTQEDWQ SFSRYGPASE EVQADSGIRD LENVKACHAR EGQMSFKTGT 1320
GDIATCDSPR TSTESCAAQD SVILASQDSQ ASNVLVMDHM ILTPEMPPAE PEGGLDESGE 1380
HFFDAREAHS DDNPSEGDGA VKKEEKDVNL RISGNCLILD GYDAVQESST DEEVASSFPL 1440
QPVTGIPAVD SSHQQQHSPQ NVHPEGPVSP FTPEFLVQRH WRAMEDTCFE IQSPSCTDSQ 1500
SQILEYIHKI EADLEHLKKV EESYALLCQR LAGSALPDKL SDKS 1545
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR001478--PDZ
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR016137--RGS
IPR015212--RGS-like_dom

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50106--PDZ
PS50003--PH_DOMAIN

Pfam

PF00595--PDZ
PF16652--PH_13
PF09128--RGS-like
PF00621--RhoGEF

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction